What is a Generic Drug?
A generic drug is a copy of the brand-name drug with the same dosage, safety, strength, quality, consumption method, performance, and intended use. Before generics become available on the market, the generic company must prove it has the same active ingredients as the brand-name drug and works in the same way and in the same amount of time in the body.
The only differences between generics and their brand-name counterparts is that generics are less expensive and may look slightly different (eg. different shape or color), as trademarks laws prevent a generic from looking exactly like the brand-name drug.
Generics are less expensive because generic manufacturers don't have to invest large sums of money to develop a drug. When the brand-name patent expires, generic companies can manufacture a copy of the brand-name and sell it at a substantial discount.
Nimotop (Nimodipine)
Prescription Required
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Product Details
Description
Nimotop is a calcium channel blocker used to treat various vascular conditions. It is indicated for preventing and treating cerebral vasospasm following subarachnoid hemorrhage (bleeding in the brain).
Nimotop belongs to the drug class dihydropyridine, and it works by inhibiting the influx of calcium ions into vascular smooth muscle cells, which ultimately relaxes the muscles of the blood vessels in the brain.
Nimotop prefers to attach to cerebral blood vessels over other blood vessels, making it useful for treating people who have experienced a bleed in the brain. Relaxing the brain’s blood vessels immediately after a bleed helps to prevent further damage and reduce the risk of brain damage.
Fact Table
Formula
C21H26N2O7
License
US FDA
Bioavailability
13%
Legal status
Prescription only (?)
Chemical Name
1,4-Dihydro-2,6-dimethyl-4-(3-nitrophenyl)-3,5-pyridinecarboxylic acid, 2-methoxyethyl ester
Elimination half-life
8-9 hours
Dosage (Strength)
30 mg tablets
Pregnancy
Consult a doctor
Brands
Nimotop, Nymalize
Protein binding
95%
PubChem CID
4495
MedlinePlus
a684027
ChEBI
7572
ATC code
C08CA06
DrugBank
DB00393
KEGG
D00441
Routes of administration
Oral, Intravenous
Directions
The usual dosage is 60 mg every four hours for 21 consecutive days.
If you have a history of liver disease, then your doctor may decrease the dosage to 30 mg every four hours.
Take your dosage one hour before or two hours after meals.
Do not crush, chew, or open the capsules.
Your doctor should start Nimotop within 96 hours after the subarachnoid hemorrhage.
Ingredients
The active ingredient in Nimotop is nimodipine.
Interactions
Common drug-drug interactions may include:
- Boceprevir
- Carbamazepine
- Ceritinib
- Clarithromycin
- Clopidogrel
- Cobicistat
- Conivaptan
- Dalfopristin
- Dantrolene
- Darunavir
- Delavirdine
- Dexamethasone
- Digoxin
- Epirubicin
- Fosphenytoin
- Indinavir
- Itraconazole
- Ketoconazole
- Lacosamide
- Lopinavir
- Melphalan
- Nefazodone
- Nelfinavir
- Phenobarbital
- Phenytoin
- Posaconazole
- Quinupristin
- Rifampin
- Rifapentine
- Ritonavir
- Saquinavir
- St John's Wort
- Tacrolimus
- Telaprevir
- Telithromycin
- Valproic Acid
- Voriconazole
Cautions
Tell your doctor if you have a history of hypertension, aortic stenosis, or liver problems before starting this drug.
Monitor your blood pressure regularly while taking Nimotop.
Tell your doctor if you have a history of gastrointestinal disease before starting this drug.
Tell your healthcare team if you are pregnant or planning to become pregnant before starting this drug.
Side Effects
Common side effects of this drug may include:
- Bradyarrhythmia
- Headache
- Hypotension
- Nausea
References
- Nimotop [package insert]. West Haven, CT: Bayer; December 2005.
IMPORTANT NOTE: The above information is intended to increase awareness of health information and does not suggest treatment or diagnosis. This information is not a substitute for individual medical attention and should not be construed to indicate that use of the drug is safe, appropriate, or effective for you. See your health care professional for medical advice and treatment.Product Code : 7203
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