Nplate (Romiplostim)
What is a Generic Drug?
A generic drug is a copy of the brand-name drug with the same dosage, safety, strength, quality, consumption method, performance, and intended use. Before generics become available on the market, the generic company must prove it has the same active ingredients as the brand-name drug and works in the same way and in the same amount of time in the body.
The only differences between generics and their brand-name counterparts is that generics are less expensive and may look slightly different (eg. different shape or color), as trademarks laws prevent a generic from looking exactly like the brand-name drug.
Generics are less expensive because generic manufacturers don't have to invest large sums of money to develop a drug. When the brand-name patent expires, generic companies can manufacture a copy of the brand-name and sell it at a substantial discount.
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Prescription Required
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Product Details
Description
Nplate (romiplostim) is an injectable medication for treating immune thrombocytopenia (ITP) in patients who are at least 1 years old.
Fact Table
Formula
C50H74N16O15S2 (peptide portion)
License
US FDA
Bioavailability
Not applicable (administered subcutaneously)
Legal status
Prescription only
Chemical Name
Romiplostim
Elimination half-life
3 to 40 days (dose-dependent)
Dosage (Strength)
250 mcg/vial, 500 mcg/vial
Pregnancy
Consult a doctor
Brands
Nplate
Protein binding
Not significantly protein bound
PubChem CID
16158265
MedlinePlus
a609024
ChEBI
CHEBI:73891
ATC code
B02BX04
DrugBank
DB05332
KEGG
D08964
Routes of administration
Subcutaneous
Directions
Nplate will be administered subcutaneously (underneath the skin) by a healthcare provider. The doctor will determine appropriate Nplate dosing for you or your child based on weight, other treatments, and platelet response.
Talk to the doctor about any questions or concerns you may have.
Ingredients
The active ingredient in Nplate is romiplostim.
Inactive ingredients include L-histidine, mannitol, polysorbate 20, sucrose, and hydrochloric acid.
Contraindications
According to the most recent Prescribing Information, there are no contraindications to receiving Nplate.
Cautions
- Before you or your child begins treatment with Nplate, tell the doctor about:
- All the prescription and over-the-counter medications you or your child takes
- Your or your child’s allergies
- Your or your child’s current health problems and past medical history
- Your or your child’s pregnancy or breastfeeding status
- Nplate may increase blast cell counts and the risk of progression to acute myelogenous leukemia in some patients with myelodysplastic syndrome
- Nplate may increase platelet counts, which can cause blood clotting problems. Portal vein thrombosis has been reported in patients with chronic liver disease who received Nplate.
- Low platelet counts can occur.
Side Effects
Joint pain, dizziness, problems sleeping, muscle pain, extremity pain, abdominal pain, shoulder pain, indigestion, tingling or numbness, and headache are common Nplate side effects in adults. Contusion, upper respiratory tract infection, and oropharyngeal pain are common Nplate side effects in pediatric patients.
Immediately notify a doctor about any side effects that bother you or your child or side effects that won’t go away.
Ask a doctor about Nplate.
Reference
Nplate. Thousand Oaks, CA: Amgen Inc.; 2022.
IMPORTANT NOTE: The above information is intended to increase awareness of health information and does not suggest treatment or diagnosis. This information is not a substitute for individual medical attention and should not be construed to indicate that use of the drug is safe, appropriate, or effective for you. See your health care professional for medical advice and treatment.Product Code : 11595
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