What is a Generic Drug?

A generic drug is a copy of the brand-name drug with the same dosage, safety, strength, quality, consumption method, performance, and intended use. Before generics become available on the market, the generic company must prove it has the same active ingredients as the brand-name drug and works in the same way and in the same amount of time in the body.

The only differences between generics and their brand-name counterparts is that generics are less expensive and may look slightly different (eg. different shape or color), as trademarks laws prevent a generic from looking exactly like the brand-name drug.

Generics are less expensive because generic manufacturers don't have to invest large sums of money to develop a drug. When the brand-name patent expires, generic companies can manufacture a copy of the brand-name and sell it at a substantial discount.

Ofev (Nintedanib)

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Brand

Ofev (Nintedanib)

Prescription Required

Strength
Qty
100mg
150mg

You'll have option to make 4 interest-free payments by credit card once your order is confirmed using Sezzle

Generic Equivalent - Ofev (Nintedanib)

Prescription Required

Strength
Qty
100mg
150mg

You'll have option to make 4 interest-free payments by credit card once your order is confirmed using Sezzle

  • Product Details

    Description

    Your healthcare provider may prescribe Ofev to treat certain lung conditions. It can be prescribed for the treatment of idiopathic pulmonary fibrosis (IPF), the treatment of chronic fibrosing interstitial lung diseases (ILDs) with a progressive phenotype, or to slow lung damage in people with systemic sclerosis-associated interstitial lung disease (SSc-ILD).

    Ofev is a tyrosine kinase inhibitor. It blocks several signal molecules called kinases that are involved in these types of lung diseases.

    Fact Table

    Formula

    C31H33N5O4

    License

    US FDA, EU EMA

    Bioavailability

    4.7%

    Legal status

    Rx-only

    Chemical Name

    Nintedanib

    Elimination half-life

    10–15 hrs

    Dosage (Strength)

    100mg, 150mg

    Pregnancy

    Consult Doctor

    Brands

    Vargatef, Ofev

    Protein binding

    97.8%

    PubChem CID

    9809715

    MedlinePlus

    a615009

    ChEBI

    85164

    ATC code

    L01EX09

    DrugBank

    DB09079

    KEGG

    D10481

    Routes of administration

    By mouth

    Directions

    Take Ofev exactly as prescribed by your doctor.

    The usual Ofev dosing is 150 mg by mouth twice daily with food.

    Your doctor may lower the dose to 100 mg twice daily if you experience side effects or have liver damage.

    Ingredients

    Nintedanib is the active ingredient in Ofev.

    Interactions

    Ofev has the potential to interact with many different drugs including:

    • Anticoagulants
    • Apalutamide
    • Atazanavir
    • Carbamazepine
    • Ceritinib
    • Clarithromycin
    • Cobicistat and cobicistat-containing coformulations
    • Darunavir
    • Enzalutamide
    • Fosphenytoin
    • Idelalisib
    • Indinavir
    • Itraconazole
    • Ketoconazole
    • Lonafarnib
    • Lopinavir
    • Lumacaftor
    • Lumacaftor-ivacaftor
    • Mifepristone
    • Mitotane
    • Nefazodone
    • Nelfinavir
    • Ombitasvir-paritaprevir-ritonavir
    • Ombitasvir-paritaprevir-ritonavir plus dasabuvir
    • Phenobarbital
    • Phenytoin
    • Posaconazole
    • Primidone
    • Rifampin (rifampicin)
    • Ritonavir and ritonavir-containing coformulations
    • Saquinavir
    • Telithromycin
    • Tobacco
    • Tucatinib
    • Voriconazole

    Ask your doctor or pharmacist before you start Ofev to review your medication list for interactions. This is not a complete list.

    Cautions

    Your doctor will measure your liver function and administer a pregnancy test to certain patients before starting Ofev.

    Ofev cannot be used in pregnancy or while breastfeeding. 

    Tell your doctor if you have a history of clotting or bleeding disorders.

    Tell your doctor if you have a history of gastrointestinal problems.

    Side Effects

    The most common side effects of Ofev may include:

    • Abdominal pain
    • Decreased appetite
    • Decreased weight
    • Diarrhea
    • Headache
    • Hypertension
    • Liver enzyme elevation
    • Nausea

    References

    1. Ofev [package insert].Ridgefield, CT: Boehringer Ingelheim Pharmaceuticals, Inc; 2020.


    IMPORTANT NOTE: The above information is intended to increase awareness of health information and does not suggest treatment or diagnosis. This information is not a substitute for individual medical attention and should not be construed to indicate that use of the drug is safe, appropriate, or effective for you. See your health care professional for medical advice and treatment.

    Product Code : 13280

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