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What is a Generic Drug?
A generic drug is a copy of the brand-name drug with the same dosage, safety, strength, quality, consumption method, performance, and intended use. Before generics become available on the market, the generic company must prove it has the same active ingredients as the brand-name drug and works in the same way and in the same amount of time in the body.
The only differences between generics and their brand-name counterparts is that generics are less expensive and may look slightly different (eg. different shape or color), as trademarks laws prevent a generic from looking exactly like the brand-name drug.
Generics are less expensive because generic manufacturers don't have to invest large sums of money to develop a drug. When the brand-name patent expires, generic companies can manufacture a copy of the brand-name and sell it at a substantial discount.
Ofev (Nintedanib)
Brand
Ofev (Nintedanib)
Prescription Required
Strength
Qty
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Product Details
Description
Your healthcare provider may prescribe Ofev to treat certain lung conditions. It can be prescribed for the treatment of idiopathic pulmonary fibrosis (IPF), the treatment of chronic fibrosing interstitial lung diseases (ILDs) with a progressive phenotype, or to slow lung damage in people with systemic sclerosis-associated interstitial lung disease (SSc-ILD).
Ofev is a tyrosine kinase inhibitor. It blocks several signal molecules called kinases that are involved in these types of lung diseases.
Fact Table
Formula
C31H33N5O4
License
US FDA, EU EMA
Bioavailability
4.7%
Legal status
Rx-only
Chemical Name
Nintedanib
Elimination half-life
10–15 hrs
Dosage (Strength)
100mg, 150mg
Pregnancy
Consult Doctor
Brands
Vargatef, Ofev
Protein binding
97.8%
PubChem CID
9809715
MedlinePlus
a615009
ChEBI
85164
ATC code
L01EX09
DrugBank
DB09079
KEGG
D10481
Routes of administration
By mouth
Directions
Take Ofev exactly as prescribed by your doctor.
The usual Ofev dosing is 150 mg by mouth twice daily with food.
Your doctor may lower the dose to 100 mg twice daily if you experience side effects or have liver damage.
Ingredients
Nintedanib is the active ingredient in Ofev.
Interactions
Ofev has the potential to interact with many different drugs including:
Anticoagulants
Apalutamide
Atazanavir
Carbamazepine
Ceritinib
Clarithromycin
Cobicistat and cobicistat-containing coformulations
Darunavir
Enzalutamide
Fosphenytoin
Idelalisib
Indinavir
Itraconazole
Ketoconazole
Lonafarnib
Lopinavir
Lumacaftor
Lumacaftor-ivacaftor
Mifepristone
Mitotane
Nefazodone
Nelfinavir
Ombitasvir-paritaprevir-ritonavir
Ombitasvir-paritaprevir-ritonavir plus dasabuvir
Phenobarbital
Phenytoin
Posaconazole
Primidone
Rifampin (rifampicin)
Ritonavir and ritonavir-containing coformulations
Saquinavir
Telithromycin
Tobacco
Tucatinib
Voriconazole
Ask your doctor or pharmacist before you start Ofev to review your medication list for interactions. This is not a complete list.
Cautions
Your doctor will measure your liver function and administer a pregnancy test to certain patients before starting Ofev.
Ofev cannot be used in pregnancy or while breastfeeding.
Tell your doctor if you have a history of clotting or bleeding disorders.
Tell your doctor if you have a history of gastrointestinal problems.
IMPORTANT NOTE:
The above information is intended to increase awareness of health information and does not suggest treatment or diagnosis. This information is not a substitute for individual medical attention and should not be construed to indicate that use of the drug is safe, appropriate, or effective for you. See your health care professional for medical advice and treatment.
Product Code : 13280
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Prescription Required
