What is a Generic Drug?

A generic drug is a copy of the brand-name drug with the same dosage, safety, strength, quality, consumption method, performance, and intended use. Before generics become available on the market, the generic company must prove it has the same active ingredients as the brand-name drug and works in the same way and in the same amount of time in the body.

The only differences between generics and their brand-name counterparts is that generics are less expensive and may look slightly different (eg. different shape or color), as trademarks laws prevent a generic from looking exactly like the brand-name drug.

Generics are less expensive because generic manufacturers don't have to invest large sums of money to develop a drug. When the brand-name patent expires, generic companies can manufacture a copy of the brand-name and sell it at a substantial discount.

Ongentys (Opicapone)


Ongentys (Opicapone)

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  • Product Details


    Ongentys (opicapone) is used with levodopa/carbidopa to treat patients with Parkinson's Disease who are experiencing “off” episodes.


    Follow the instructions that come with your prescription. If you have any questions or concerns, talk to your doctor or pharmacist.

    Ongentys is available in 25 mg and 50 mg oral capsules.

    Recommended dose: 50 mg by mouth once daily at bedtime. Food should be avoided for at least 1 hour before and 1 hour after taking Ongentys. The dose may be adjusted in patients with liver problems. 


    Each capsule contains opicapone, a selective and reversible catechol-O-methyltransferase (COMT) inhibitor.


    Do not take Ongentys with non-selective monoamine oxidase (MAO) inhibitors. Ask your doctor if you are unsure whether or not you take MAO inhibitors.

    Do not take Ongentys if you have ever had pheochromocytoma, paraganglioma, or other tumors that secrete catecholamines.


    • Before you start treatment with Ongentys, tell your doctor:
      • About all the prescription and over-the-counter medications you take, including vitamins and herbal supplements.
      • About your allergies.
      • About your health conditions.
      • If you are pregnant or planning to become pregnant. Ongentys may cause harm to an unborn baby.
      • If you are breastfeeding or planning to breastfeed. It has not been determined whether or not Ongentys is transmitted through breast milk. 
    • You should avoid treatment with Ongentys if you have end-stage kidney disease.
    • Ongentys can cause a rapid heart rate, arrhythmias, and blood pressure changes. Seek care right away if you experience any of these effects.
    • Ongentys can cause you to feel sleepy or fall asleep, even during the daytime or during normal activities. You should not drive or operate machinery until you know how Ongentys affects you.
    • Ongentys can cause low blood pressure. Your blood pressure should be monitored during treatment with Ongentys.
    • Ongentys can cause or worsen dyskinesia, or sudden involuntary movements. Tell your doctor right away if this occurs.
    • Ongentys can cause hallucinations or psychosis. Tell your doctor right away if these occur.
    • Ongentys can cause impulsive behaviors or intense and uncontrollable urges to gamble, spend money, binge eat, and/or other urges. Tell your doctor right away if you experience these behaviors or urges.
    • A sudden withdrawal or dose decrease can cause withdrawal-emergent hyperpyrexia and confusion with symptoms that may include a fever, stiff muscles, altered mental status, and autonomic instability. Ongentys should be slowly tapered or gradually withdrawn.

    Side Effects

    Ongentys can cause side effects, including sudden and involuntary movements, constipation, low blood pressure, weight loss, and an elevated blood creatine kinase. However, these are not all the possible side effects of Ongentys. Call your doctor right away if you develop side effects that are troublesome or won't go away.


    Ongentys (opicapone) capsules, for oral use. San Diego, CA: Neurocrine Biosciences, Inc.; 2020.

    IMPORTANT NOTE: The above information is intended to increase awareness of health information and does not suggest treatment or diagnosis. This information is not a substitute for individual medical attention and should not be construed to indicate that use of the drug is safe, appropriate, or effective for you. See your health care professional for medical advice and treatment.

    Product Code : 13648

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