What is a Generic Drug?

A generic drug is a copy of the brand-name drug with the same dosage, safety, strength, quality, consumption method, performance, and intended use. Before generics become available on the market, the generic company must prove it has the same active ingredients as the brand-name drug and works in the same way and in the same amount of time in the body.

The only differences between generics and their brand-name counterparts is that generics are less expensive and may look slightly different (eg. different shape or color), as trademarks laws prevent a generic from looking exactly like the brand-name drug.

Generics are less expensive because generic manufacturers don't have to invest large sums of money to develop a drug. When the brand-name patent expires, generic companies can manufacture a copy of the brand-name and sell it at a substantial discount.

Onzetra Xsail (Sumatriptan nasal powder)


Onzetra Xsail (Sumatriptan nasal powder)

Prescription Required

11mg 16 Nosepieces

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  • Product Details


    Onzetra Xsail is a prescription drug that you may start taking to treat migraine headaches. It should only be used to treat migraine headaches and cannot be used to prevent migraines. It cannot be used for the treatment of cluster headaches.

    Migraines involve a variety of symptoms that affect the nerves of the brain and usually involve headaches with severe pain. Symptoms include dull or throbbing pain in the face or neck, sensitivity to light, vision changes, dizziness, lightheadedness, sensitivity to sound, nausea, and vomiting.

    Onzetra Xsail works by activating serotonin receptors in the brain's blood vessels. It also affects the trigeminal nerves. By activating serotonin receptors, it constricts blood vessels and reduces inflammation.

    Fact Table




    US FDA


    15% - 96%

    Legal status

    US: RX Only

    Chemical Name


    Elimination half-life

    2.5 hours

    Dosage (Strength)



    Consult Doctor


    Onzetra Xsail , Imitrex, Imigran

    Protein binding


    PubChem CID






    ATC code






    Routes of administration

    By mouth, subcutaneous injection, nasal spray, transdermal electrophoresis


    Use Onzetra Xsail exactly as prescribed by your physician. 

    First, open the pouch and remove the first nosepiece. Remove the device cover and insert the nosepiece until it clicks. Press and release the white button to pierce the medication capsule. Then, insert the nosepiece and blow with the mouth into the device for 2-3 seconds. Repeat for the second nostril.

    The starting dosage is 11 mg once by inhalation in each nostril. Do not exceed 44 mg or two doses in 24 hours.


    The active ingredient in Onzetra Xsail is sumatriptan.


    Common drug interactions may include:

    • Bromocriptine
    • Buspirone
    • Citalopram
    • Clomipramine
    • Dextromethorphan
    • Dihydroergotamine 
    • Droxidopa
    • Ergotamine 
    • Escitalopram
    • Fluoxetine
    • Fluvoxamine
    • Imipramine
    • Mirtazapine
    • Monoamine Oxidase Inhibitors
    • Paroxetine
    • Sertraline
    • Trazodone
    • Venlafaxine


    Tell your doctor if you have a history of heart problems, vascular disease, or liver disease before starting Onzetra Xsail.

    Side Effects

    Common side effects can include:

    • Dizziness
    • Dysgeusia 
    • Local irritation
    • Localized burning
    • Localized numbness
    • Nasal cavity pain
    • Nasal discomfort
    • Nausea
    • Paresthesia
    • Rhinitis
    • Rhinorrhea
    • Sinus discomfort
    • Sore nose
    • Unusual taste
    • Vertigo
    • Vomiting


    1. Onzetra Xsail. Bristol, TN: Avanir; 2016.

    IMPORTANT NOTE: The above information is intended to increase awareness of health information and does not suggest treatment or diagnosis. This information is not a substitute for individual medical attention and should not be construed to indicate that use of the drug is safe, appropriate, or effective for you. See your health care professional for medical advice and treatment.

    Product Code : 13617

  • Product Reviews


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