Orencia (Abatacept)
What is a Generic Drug?
A generic drug is a copy of the brand-name drug with the same dosage, safety, strength, quality, consumption method, performance, and intended use. Before generics become available on the market, the generic company must prove it has the same active ingredients as the brand-name drug and works in the same way and in the same amount of time in the body.
The only differences between generics and their brand-name counterparts is that generics are less expensive and may look slightly different (eg. different shape or color), as trademarks laws prevent a generic from looking exactly like the brand-name drug.
Generics are less expensive because generic manufacturers don't have to invest large sums of money to develop a drug. When the brand-name patent expires, generic companies can manufacture a copy of the brand-name and sell it at a substantial discount.
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Prescription Required
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Product Details
Description
Orencia is a prescription medication used to treat moderate to severe rheumatoid arthritis, polyarticular juvenile idiopathic arthritis, and psoriatic arthritis. It is also used for the prevention of acute graft versus host disease (aGVHD) in patients who are at least 2 years of age and are receiving hematopoietic stem cell transplantation (HSCT).
Orencia is not recommended to be used with other medications that suppress the immune system, such as biological disease-modifying antirheumatic drugs (dMARDS) and Janus kinase (JAK) inhibitors.
Orencia is available as a subcutaneous injection in a single-dose prefilled syringe or a single-dose prefilled ClickJectâ„¢ autoinjector.
Fact Table
Formula
C3498H5458N922O1090S32
License
US FDA, EU EMA
Bioavailability
78.6%
Legal status
Rx-Only
Chemical Name
Abatacept
Elimination half-life
13.1 days
Dosage (Strength)
-
Pregnancy
Consult Doctor
Brands
Orencia
Protein binding
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PubChem CID
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MedlinePlus
a606016
ChEBI
-
ATC code
L04AA24
DrugBank
DB01281
KEGG
D03203
Routes of administration
Intravenous, subcutaneous
Directions
Use Orencia injection as directed by your doctor. Tell your doctor or pharmacist about any questions or concerns you may have about the medication.
If you or a caregiver will be administering your Orencia at home, your doctor will tell you or your caregiver how to prepare and inject Orencia, how much should be injected, and how often it should be injected.
Follow the storage instructions that come with your prescription. Orencia prefilled syringes and ClickJect autoinjectors should be kept out of light; refrigerated in their original containers between 36°F and 46°F (2°C and 8°C). Do not freeze and do not use it if the product is expired.
Ingredients
Abatacept, a selective T cell costimulation modulator, is the active ingredient contained in Orencia.
Dibasic sodium phosphate anhydrous, monobasic sodium phosphate monohydrate, poloxamer 188, sucrose, and water for injection are the inactive ingredients included.
Contraindications
According to Orencia’s most recent Prescribing Information, there are no known contraindications to receiving the medication.
Cautions
- Before you begin treatment with Orencia medication, talk to your doctor about:
- All the medications you take
- Your allergies
- Your health conditions and medical history
- Your pregnancy or breastfeeding status
- The risk of infections can be increased by using Orencia with TNF antagonists. Tell your doctor if you are unsure whether you take these medications.
- Orencia can cause serious allergic reactions, including anaphylaxis. Seek emergency care right away if you have trouble breathing; swelling of the face, lips, tongue, or throat; a rash; or a rapid heart rate.
- Serious infections can occur with Orencia use, especially in patients who have recurrent infections or a condition that increases their risk for infections.
- Patients should be screened for tuberculosis and viral hepatitis before starting treatment with Orencia.
- Patients should not receive live vaccines while being treated with Orencia or within 3 months of stopping Orencia.
- Patients with COPD may have more frequent respiratory issues when being treated with Orencia.
- Patients who use Orencia to prevent aGVHD may experience reactivation of cytomegalovirus and Epstein-Barr Virus.
Side Effects
Orencia can cause the following side effects: headache, upper respiratory tract infection, nasopharyngitis, and nausea. Other side effects may also occur, so be sure to tell your doctor about any bothersome or persistent side effects you experience while being treated with Orencia.
You can buy Orencia online at a competitive price and with a valid prescription from your doctor at Canada Pharmacy.
Reference:
Orencia. Princeton, NJ: Bristol-Myers Squibb Company; 2021.
IMPORTANT NOTE: The above information is intended to increase awareness of health information and does not suggest treatment or diagnosis. This information is not a substitute for individual medical attention and should not be construed to indicate that use of the drug is safe, appropriate, or effective for you. See your health care professional for medical advice and treatment.Product Code : 11373
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