Description
Osphena is an oral medication that is used to treat different symptoms of menopause, including severe dyspareunia (painful vaginal intercourse) and vaginal dryness due to menopause.
Osphena is used for the treatment of symptoms of menopause but can increase your risk for other diseases. Talk with your doctor carefully before starting this drug.
Fact Table |
Formula |
C24H23ClO2 |
License |
EU EMA, US FDA |
Bioavailability |
- |
Legal status |
Rx Only |
Chemical Name |
Ospemifene |
Elimination half-life |
22hr |
Dosage (Strength) |
60mg |
Pregnancy |
Consult Doctor |
Brands |
Osphena, Senshio |
Protein binding |
99% |
PubChem CID |
3036505
|
MedlinePlus |
a613039 |
ChEBI |
73275 |
ATC code |
G03XC05 |
DrugBank |
DB04938 |
KEGG |
D08958
|
Routes of administration |
By mouth |
Directions
Take Osphena exactly as directed by your doctor. The standard dosage is 60 mg by mouth once daily.
Ingredients
The active ingredient in Osphena is ospemifene.
Ospemifene has two mechanisms, it activates certain estrogen receptors and shuts off other receptors. By doing so, it regulates the amount of estrogen activation in different tissues of the body.
Interactions
Common drug-drug interactions with Osphena can include:
- Abametapir
- Apalutamide
- Fexinidazole
- Fluconazole
- Fusidic Acid (Systemic)
- Selective Estrogen Receptor Modulators
- Atazanavir
- Ceritinib
- Clarithromycin
- Cobicistat and cobicistat-containing coformulations
- Darunavir
- Fluoroestradiol F18
- Idelalisib
- Indinavir
- Itraconazole
- Ketoconazole
- Levoketoconazole
- Lonafarnib
- Lopinavir
- Mifepristone
- Nefazodone
- Nelfinavir
- Ombitasvir-paritaprevir-ritonavir
- Ombitasvir-paritaprevir-ritonavir plus dasabuvir
- Posaconazole
- Ritonavir and ritonavir-containing formulations
- Saquinavir
- Telithromycin
- Tucatinib
- Voriconazole
Cautions
Do not take Osphena if you have a history of endometrial cancer or uterine cancer. You should be regularly screened for cancer risk if you are taking Osphena.
Tell your doctor if you have a history of clotting disorders like deep vein thrombosis, pulmonary embolism, or heart attack.
Side Effects
When taking Osphena, some of the more common side effects can include:
- Angioedema
- Cerebrovascular accident
- Cysts
- Deep vein thrombosis
- Endometrial carcinoma
- Endometrial hyperplasia
- Endometrial polyps
- Erythematous rash
- Headache
- Hot flash
- Hyperhidrosis
- Hypersensitivity reaction
- Malignant neoplasm
- Myocardial infarction
- Night Sweats
- Pruritus
- Pulmonary embolism
- Vaginal discharge
- Vaginal hemorrhage
Let your healthcare team know if you are experiencing any of the above side effects. You may need to stop the medication if symptoms are severe.
References
Osphena. Florham Park, NJ: Shionogi Inc; 1/2019.
About Dr. Conor Sheehy (Page Author)
Dr. Sheehy (BSc Molecular Biology, PharmD) works a clinical pharmacist specializing in cardiology, oncology, and ambulatory care. He’s a board-certified pharmacotherapy specialist (BCPS), and his experience working one-on-one with patients to fine tune their medication and therapy plans for optimal results makes him a valuable subject matter expert for our pharmacy. Read More....
IMPORTANT NOTE:
The above information is intended to increase awareness of health information and does not suggest treatment or diagnosis. This information is not a substitute for individual medical attention and should not be construed to indicate that use of the drug is safe, appropriate, or effective for you. See your health care professional for medical advice and treatment.
Product Code : 13585