What is a Generic Drug?

A generic drug is a copy of the brand-name drug with the same dosage, safety, strength, quality, consumption method, performance, and intended use. Before generics become available on the market, the generic company must prove it has the same active ingredients as the brand-name drug and works in the same way and in the same amount of time in the body.

The only differences between generics and their brand-name counterparts is that generics are less expensive and may look slightly different (eg. different shape or color), as trademarks laws prevent a generic from looking exactly like the brand-name drug.

Generics are less expensive because generic manufacturers don't have to invest large sums of money to develop a drug. When the brand-name patent expires, generic companies can manufacture a copy of the brand-name and sell it at a substantial discount.

Osphena (Ospemifene)

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Brand

Osphena (Ospemifene)

Prescription Required

Strength
Qty
60mg

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  • Product Details

    Description

    Osphena is an oral medication that is used to treat different symptoms of menopause, including severe dyspareunia (painful vaginal intercourse) and vaginal dryness due to menopause.

    Osphena is used for the treatment of symptoms of menopause but can increase your risk for other diseases. Talk with your doctor carefully before starting this drug.

    Fact Table

    Formula

    C24H23ClO2

    License

    EU EMA, US FDA

    Bioavailability

    -

    Legal status

    Rx Only

    Chemical Name

    Ospemifene

    Elimination half-life

    22hr

    Dosage (Strength)

    60mg

    Pregnancy

    Consult Doctor

    Brands

    Osphena, Senshio

    Protein binding

    99%

    PubChem CID

    3036505

    MedlinePlus

    a613039

    ChEBI

    73275

    ATC code

    G03XC05

    DrugBank

    DB04938

    KEGG

    D08958

    Routes of administration

    By mouth

    Directions

    Take Osphena exactly as directed by your doctor. The standard dosage is 60 mg by mouth once daily.

    Ingredients

    The active ingredient in Osphena is ospemifene.

    Ospemifene has two mechanisms, it activates certain estrogen receptors and shuts off other receptors. By doing so, it regulates the amount of estrogen activation in different tissues of the body.

    Interactions

    Common drug-drug interactions with Osphena can include:

    • Abametapir
    • Apalutamide
    • Fexinidazole
    • Fluconazole
    • Fusidic Acid (Systemic)
    • Selective Estrogen Receptor Modulators
    • Atazanavir
    • Ceritinib
    • Clarithromycin
    • Cobicistat and cobicistat-containing coformulations
    • Darunavir
    • Fluoroestradiol F18
    • Idelalisib
    • Indinavir
    • Itraconazole
    • Ketoconazole
    • Levoketoconazole
    • Lonafarnib
    • Lopinavir
    • Mifepristone
    • Nefazodone
    • Nelfinavir
    • Ombitasvir-paritaprevir-ritonavir
    • Ombitasvir-paritaprevir-ritonavir plus dasabuvir
    • Posaconazole
    • Ritonavir and ritonavir-containing formulations
    • Saquinavir
    • Telithromycin
    • Tucatinib
    • Voriconazole

    Cautions

    Do not take Osphena if you have a history of endometrial cancer or uterine cancer. You should be regularly screened for cancer risk if you are taking Osphena.

    Tell your doctor if you have a history of clotting disorders like deep vein thrombosis, pulmonary embolism, or heart attack.

    Side Effects

    When taking Osphena, some of the more common side effects can include:

    • Angioedema
    • Cerebrovascular accident
    • Cysts
    • Deep vein thrombosis
    • Endometrial carcinoma
    • Endometrial hyperplasia
    • Endometrial polyps
    • Erythematous rash
    • Headache
    • Hot flash
    • Hyperhidrosis
    • Hypersensitivity reaction
    • Malignant neoplasm
    • Myocardial infarction
    • Night Sweats
    • Pruritus
    • Pulmonary embolism
    • Vaginal discharge
    • Vaginal hemorrhage

    Let your healthcare team know if you are experiencing any of the above side effects. You may need to stop the medication if symptoms are severe.

    References


    Osphena. Florham Park, NJ: Shionogi Inc; 1/2019.

    Dr Conor Sheehy
    About Dr. Conor Sheehy (Page Author)

    Dr. Sheehy (BSc Molecular Biology, PharmD) works a clinical pharmacist specializing in cardiology, oncology, and ambulatory care. He’s a board-certified pharmacotherapy specialist (BCPS), and his experience working one-on-one with patients to fine tune their medication and therapy plans for optimal results makes him a valuable subject matter expert for our pharmacy. Read More....


    IMPORTANT NOTE: The above information is intended to increase awareness of health information and does not suggest treatment or diagnosis. This information is not a substitute for individual medical attention and should not be construed to indicate that use of the drug is safe, appropriate, or effective for you. See your health care professional for medical advice and treatment.

    Product Code : 13585

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