A generic drug is a copy of the brand-name drug with the same dosage, safety, strength, quality, consumption method, performance, and intended use. Before generics become available on the market, the generic company must prove it has the same active ingredients as the brand-name drug and works in the same way and in the same amount of time in the body.
The only differences between generics and their brand-name counterparts is that generics are less expensive and may look slightly different (eg. different shape or color), as trademarks laws prevent a generic from looking exactly like the brand-name drug.
Generics are less expensive because generic manufacturers don't have to invest large sums of money to develop a drug. When the brand-name patent expires, generic companies can manufacture a copy of the brand-name and sell it at a substantial discount.
Otezla (apremilast) is an oral tablet taken by adults who have active psoriatic arthritis, plaque psoriasis and are candidates for phototherapy or systemic therapy, and oral ulcers related to Behçet’s Disease.
The instructions that come with your Otezla prescription should be followed. Talk to your doctor or pharmacist if you have any questions or concerns.
Oteza comes in 10 mg, 20 mg, and 30 mg tablets.
Because Otezla can cause gastrointestinal problems, it is recommended to steadily titrate Otezla until a dose of 30 mg by mouth two times a day is reached according to the suggested schedule:
Day 1: 10 mg by mouth in the morning
Day 2: 10 mg by mouth in the morning and 10 mg by mouth in the evening
Day 3: 10 mg by mouth in the morning and 20 mg by mouth in the evening
Day 4: 20 mg by mouth in the morning and 20 mg by mouth in the evening
Day 5: 20 mg by mouth in the morning and 30 mg by mouth in the evening
Day 6 and thereafter: 30 mg by mouth two times a day
The dose may be adjusted based on kidney function.
Apremilast, a phosphodiesterase 4 (PDE4) inhibitor, is the active ingredient in each Otezla tablet. The inactive ingredients include lactose monohydrate, microcrystalline cellulose, croscarmellose sodium, magnesium stearate, polyvinyl alcohol, titanium dioxide, polyethylene glycol, talc, and iron oxide red. The 20 mg and 30 mg tablets also contain iron oxide yellow. The 30 mg tablet also contains iron oxide black.
Do not take Oteza if you are allergic to apremilast or to any of the other ingredients or excipients contained in Otezla tablets.
The most common Otezla side effects include diarrhea, nausea, headache, and upper respiratory tract infection; however, these are not all the side effects that can occur with the use of Otezla. Contact your doctor immediately if you have bothersome or persistent side effects.
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Otezla (apremilast) tablets, for oral use. Thousand Oaks, CA: Amgen Inc.; 2021.