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Ovidrel (Choriogonadotropin)

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  • Product Details

    Description

    Ovidrel is a recombinant form of human chorionic gonadotropin (choriogonadotropin alfa), indicated for the induction of final follicular maturation and triggering of ovulation in women undergoing assisted reproductive technologies (ART) such as in vitro fertilization (IVF), or for ovulation induction in anovulatory or oligo-ovulatory patients. Produced using recombinant DNA technology, Ovidrel mimics the natural luteinizing hormone (LH) surge that initiates ovulation. It is administered as a single subcutaneous injection and is widely used in fertility treatment protocols.

    Fact Table

    Formula

    C960H1514N262O301S26 (glycoprotein)

    License

    US FDA (2000), EMA

    Bioavailability

    ~40% (subcutaneous)

    Legal status

    Rx-only

    Chemical Name

    Choriogonadotropin alfa (recombinant hCG)

    Elimination half-life

    ~30 hours (SC route)

    Dosage (Strength)

    250 mcg/0.5 mL prefilled syringe (SC injection)

    Pregnancy

    Category C – not recommended once pregnancy is achieved

    Brands

    Ovidrel, Ovitrelle (EU)

    Protein binding

    Not extensively bound; receptor-mediated activity

    PubChem CID

    16129680

    MedlinePlus

    a601002

    ChEBI

    CHEBI:37737

    ATC code

    G03GA08

    DrugBank

    DB00011

    KEGG

    D08138

    Routes of administration

    Subcutaneous injection

    Directions

    Ovidrel is administered as a single subcutaneous injection of 250 micrograms, typically 24 to 36 hours before the scheduled time of oocyte retrieval or timed intercourse. The injection should be given under the supervision of a fertility specialist, and proper training in injection technique should be provided if self-administered at home. Timing is critical and should follow ovarian stimulation and follicular monitoring to ensure optimal results.

    Ingredients

    Each prefilled syringe of Ovidrel contains:

    • Choriogonadotropin alfa 250 micrograms (equivalent to approximately 6,500 IU)
    • Excipients: mannitol, L-methionine, poloxamer 188, phosphoric acid (for pH adjustment), and water for injection

    Contraindications

    Ovidrel is contraindicated in patients with:

    • Hypersensitivity to choriogonadotropin alfa or any component of the formulation
    • Primary ovarian failure or ovarian cysts unrelated to polycystic ovary syndrome
    • Uncontrolled thyroid or adrenal dysfunction
    • Pituitary or hypothalamic tumors
    • Known or suspected hormone-dependent tumors
    • Pregnancy or breastfeeding

    Cautions

    Use of Ovidrel can increase the risk of ovarian hyperstimulation syndrome (OHSS), especially in women with polycystic ovary syndrome or high estradiol levels. Patients should be monitored carefully with ultrasound and serum estradiol measurements. Ovidrel does not prevent pregnancy, and multiple gestations may occur. The product should only be used under the care of a specialist experienced in infertility treatment.

    Side Effects

    Common and potential side effects include:

    • Abdominal pain or bloating
    • Nausea or vomiting
    • Injection site reactions such as redness, swelling, or discomfort
    • Headache or fatigue
    • Breast tenderness
    • Ovarian hyperstimulation syndrome (OHSS), in moderate to severe cases
    • Rarely, allergic reactions or thromboembolic events

    IMPORTANT NOTE: The above information is intended to increase awareness of health information and does not suggest treatment or diagnosis. This information is not a substitute for individual medical attention and should not be construed to indicate that use of the drug is safe, appropriate, or effective for you. See your health care professional for medical advice and treatment.

    Product Code : 10872

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