What is a Generic Drug?
A generic drug is a copy of the brand-name drug with the same dosage, safety, strength, quality, consumption method, performance, and intended use. Before generics become available on the market, the generic company must prove it has the same active ingredients as the brand-name drug and works in the same way and in the same amount of time in the body.
The only differences between generics and their brand-name counterparts is that generics are less expensive and may look slightly different (eg. different shape or color), as trademarks laws prevent a generic from looking exactly like the brand-name drug.
Generics are less expensive because generic manufacturers don't have to invest large sums of money to develop a drug. When the brand-name patent expires, generic companies can manufacture a copy of the brand-name and sell it at a substantial discount.
Pifeltro (Doravirine)
Prescription Required
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Product Details
Description
Pifeltro is an antiviral medication that your doctor may prescribe for the treatment of human immunodeficiency virus (HIV-1) infection. HIV infection causes Acquired Immunodeficiency Syndrome (AIDS), which is a long-term and fatal condition if not treated.
When an HIV viral particle infects an immune system cell, it uses reverse transcriptase (RT) protein to replicate itself. Pifeltro works by incorporating into RT and stopping it from working. By shutting down RT, Pifeltro stops HIV viruses from replicating.
Fact Table
Formula
C17H11ClF3N5O3
License
US FDA
Bioavailability
64%
Legal status
Rx-only
Chemical Name
Doravirine
Elimination half-life
12-21h
Dosage (Strength)
100mg
Pregnancy
Consult Doctor
Brands
Pifeltro
Protein binding
76%
PubChem CID
58460047
MedlinePlus
a618048
ChEBI
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ATC code
J05AG06
DrugBank
DB12301
KEGG
D10624
Routes of administration
By mouth
Directions
The standard dosage is 100 mg by mouth once daily with or without food. This dosage should be used in people who weigh 35 kilograms or more.
If you are taking rifabutin, your prescriber may adjust the dosage to 100 mg by mouth twice daily.
Ingredients
The active ingredient in this drug is doravirine.
Interactions
Pifeltro has many possible drug-drug interactions. Tell your doctor and pharmacist about any of the following that you are taking:
- Apalutamide
- Bexarotene
- Bosentan
- Carbamazepine
- Cenobamate
- Dabrafenib
- Dexamethasone
- Dipyrone
- Efavirenz
- Elagolix, estradiol, and norethindrone therapy pack?
- Enzalutamide
- Eslicarbazepine
- Etravirine
- Fosphenytoin
- Lorlatinib
- Lumacaftor
- Mitapivat
- Mitotane
- Modafinil
- Nafcillin
- Pexidartinib
- Phenobarbital
- Phenytoin
- Primidone
- Rifabutin
- Rifampin (rifampicin)
- Rifapentine
- Sotorasib
- St. John's wort
Cautions
Pifeltro is contraindicated for people who are taking strong CYP3A4 inducers. Ask your doctor and pharmacist if you are taking one of these medications before starting Pifeltro.
Your doctor should monitor for Immune Reconstitution Syndrome while taking this medication. This occurs when Pifeltro begins to reduce the numbers of HIV viral particles and the immune system becomes too active.
Side Effects
The most common Pifeltro side effects include:
- Abdominal pain
- Abnormal dreams
- Diarrhea
- Dizziness
- Fatigue
- Headache
- Increased LDL cholesterol
- Increased serum alkaline phosphatase
- Increased serum aspartate aminotransferase
- Increased serum bilirubin
- Increased serum creatine kinase
- Increased serum creatinine
- Increased serum lipase
- Increased serum triglycerides
- Insomnia
- Nausea
- Skin rash
References
Pifeltro. Whitehouse Station, NJ: Merck Sharp & Dohme Corp.; 2018.
IMPORTANT NOTE: The above information is intended to increase awareness of health information and does not suggest treatment or diagnosis. This information is not a substitute for individual medical attention and should not be construed to indicate that use of the drug is safe, appropriate, or effective for you. See your health care professional for medical advice and treatment.Product Code : 13620
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