What is a Generic Drug?

A generic drug is a copy of the brand-name drug with the same dosage, safety, strength, quality, consumption method, performance, and intended use. Before generics become available on the market, the generic company must prove it has the same active ingredients as the brand-name drug and works in the same way and in the same amount of time in the body.

The only differences between generics and their brand-name counterparts is that generics are less expensive and may look slightly different (eg. different shape or color), as trademarks laws prevent a generic from looking exactly like the brand-name drug.

Generics are less expensive because generic manufacturers don't have to invest large sums of money to develop a drug. When the brand-name patent expires, generic companies can manufacture a copy of the brand-name and sell it at a substantial discount.

Pifeltro (Doravirine)

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Brand

Pifeltro (Doravirine)

Prescription Required

Strength
Qty
100mg

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  • Product Details

    Description

    Pifeltro is an antiviral medication that your doctor may prescribe for the treatment of human immunodeficiency virus (HIV-1) infection. HIV infection causes Acquired Immunodeficiency Syndrome (AIDS), which is a long-term and fatal condition if not treated.

    When an HIV viral particle infects an immune system cell, it uses reverse transcriptase (RT) protein to replicate itself. Pifeltro works by incorporating into RT and stopping it from working. By shutting down RT, Pifeltro stops HIV viruses from replicating.

    Directions

    The standard dosage is 100 mg by mouth once daily with or without food. This dosage should be used in people who weigh 35 kilograms or more. 

    If you are taking rifabutin, your prescriber may adjust the dosage to 100 mg by mouth twice daily.

    Ingredients

    The active ingredient in this drug is doravirine.

    Interactions

    Pifeltro has many possible drug-drug interactions. Tell your doctor and pharmacist about any of the following that you are taking:

    • Apalutamide
    • Bexarotene
    • Bosentan
    • Carbamazepine
    • Cenobamate
    • Dabrafenib
    • Dexamethasone
    • Dipyrone
    • Efavirenz
    • Elagolix, estradiol, and norethindrone therapy pack?
    • Enzalutamide
    • Eslicarbazepine
    • Etravirine
    • Fosphenytoin
    • Lorlatinib
    • Lumacaftor
    • Mitapivat
    • Mitotane
    • Modafinil
    • Nafcillin
    • Pexidartinib
    • Phenobarbital
    • Phenytoin
    • Primidone
    • Rifabutin
    • Rifampin (rifampicin)
    • Rifapentine
    • Sotorasib
    • St. John's wort

    Cautions

    Pifeltro is contraindicated for people who are taking strong CYP3A4 inducers. Ask your doctor and pharmacist if you are taking one of these medications before starting Pifeltro.

    Your doctor should monitor for Immune Reconstitution Syndrome while taking this medication. This occurs when Pifeltro begins to reduce the numbers of HIV viral particles and the immune system becomes too active.

    Side Effects

    The most common Pifeltro side effects include:

    • Abdominal pain
    • Abnormal dreams
    • Diarrhea
    • Dizziness
    • Fatigue
    • Headache
    • Increased LDL cholesterol
    • Increased serum alkaline phosphatase
    • Increased serum aspartate aminotransferase
    • Increased serum bilirubin
    • Increased serum creatine kinase
    • Increased serum creatinine
    • Increased serum lipase
    • Increased serum triglycerides
    • Insomnia
    • Nausea
    • Skin rash


    Buy Pifeltro from Canada Pharmacy.

    References

    Pifeltro. Whitehouse Station, NJ: Merck Sharp & Dohme Corp.; 2018.


    IMPORTANT NOTE: The above information is intended to increase awareness of health information and does not suggest treatment or diagnosis. This information is not a substitute for individual medical attention and should not be construed to indicate that use of the drug is safe, appropriate, or effective for you. See your health care professional for medical advice and treatment.

    Product Code : 13620

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