A generic drug is a copy of the brand-name drug with the same dosage, safety, strength, quality, consumption method, performance, and intended use. Before generics become available on the market, the generic company must prove it has the same active ingredients as the brand-name drug and works in the same way and in the same amount of time in the body.
The only differences between generics and their brand-name counterparts is that generics are less expensive and may look slightly different (eg. different shape or color), as trademarks laws prevent a generic from looking exactly like the brand-name drug.
Generics are less expensive because generic manufacturers don't have to invest large sums of money to develop a drug. When the brand-name patent expires, generic companies can manufacture a copy of the brand-name and sell it at a substantial discount.
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Pifeltro is an antiviral medication that your doctor may prescribe for the treatment of human immunodeficiency virus (HIV-1) infection. HIV infection causes Acquired Immunodeficiency Syndrome (AIDS), which is a long-term and fatal condition if not treated.
When an HIV viral particle infects an immune system cell, it uses reverse transcriptase (RT) protein to replicate itself. Pifeltro works by incorporating into RT and stopping it from working. By shutting down RT, Pifeltro stops HIV viruses from replicating.
The standard dosage is 100 mg by mouth once daily with or without food. This dosage should be used in people who weigh 35 kilograms or more.
If you are taking rifabutin, your prescriber may adjust the dosage to 100 mg by mouth twice daily.
The active ingredient in this drug is doravirine.
Pifeltro has many possible drug-drug interactions. Tell your doctor and pharmacist about any of the following that you are taking:
Pifeltro is contraindicated for people who are taking strong CYP3A4 inducers. Ask your doctor and pharmacist if you are taking one of these medications before starting Pifeltro.
Your doctor should monitor for Immune Reconstitution Syndrome while taking this medication. This occurs when Pifeltro begins to reduce the numbers of HIV viral particles and the immune system becomes too active.
The most common Pifeltro side effects include:
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Pifeltro. Whitehouse Station, NJ: Merck Sharp & Dohme Corp.; 2018.