What is a Generic Drug?

A generic drug is a copy of the brand-name drug with the same dosage, safety, strength, quality, consumption method, performance, and intended use. Before generics become available on the market, the generic company must prove it has the same active ingredients as the brand-name drug and works in the same way and in the same amount of time in the body.

The only differences between generics and their brand-name counterparts is that generics are less expensive and may look slightly different (eg. different shape or color), as trademarks laws prevent a generic from looking exactly like the brand-name drug.

Generics are less expensive because generic manufacturers don't have to invest large sums of money to develop a drug. When the brand-name patent expires, generic companies can manufacture a copy of the brand-name and sell it at a substantial discount.

Rapamune (Sirolimus)


Rapamune (Sirolimus)

Prescription Required


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Generic Equivalent - Rapamune (Sirolimus)

Prescription Required


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  • Product Details


    Rapamune is a medication used to prevent organ rejection in people who have received kidney transplants. It is indicated for patients who are 13 years of age or older.


    Take Rapamune exactly as prescribed by your doctor.


    The active ingredient in Rapamune is sirolimus.


    Tell your transplant team and pharmacist about all the medications you are taking. If you start a start medication without telling your healthcare providers, you may be at risk of transplant rejection.

    Drug-drug interactions include:

    • Amiodarone
    • Apalutamide
    • Aprepitant
    • Atazanavir
    • Berotralstat
    • Bexarotene
    • Bosentan
    • Carbamazepine
    • Cenobamate
    • Ceritinib
    • Cimetidine
    • Clarithromycin
    • Cobicistat and cobicistat-containing coformulations
    • Conivaptan
    • Crizotinib
    • Cyclosporine
    • Dabrafenib
    • Darunavir
    • Dexamethasone
    • Diltiazem
    • Dronedarone
    • Duvelisib
    • Efavirenz
    • Enzalutamide
    • Erythromycin
    • Eslicarbazepine
    • Etravirine
    • Fedratinib
    • Fluconazole
    • Fosamprenavir
    • Fosaprepitant
    • Fosphenytoin
    • Grapefruit juice
    • Idelalisib
    • Imatinib
    • Indinavir
    • Isavuconazole (isavuconazonium sulfate)
    • Itraconazole
    • Ketoconazole
    • Lefamulin
    • Letermovir
    • Lonafarnib
    • Lopinavir
    • Lorlatinib
    • Lumacaftor
    • Mifepristone
    • Mitotane
    • Modafinil
    • Nafcillin
    • Nefazodone
    • Nelfinavir
    • Netupitant
    • Nilotinib
    • Ombitasvir-paritaprevir-ritonavir
    • Pexidartinib
    • Phenobarbital
    • Phenytoin
    • Posaconazole
    • Primidone
    • Ribociclib
    • Rifabutin
    • Rifampin (rifampicin)
    • Rifapentine
    • Ritonavir and ritonavir-containing coformulations
    • Saquinavir
    • Schisandra
    • St. John's wort
    • Telithromycin
    • Tucatinib
    • Verapamil
    • Voriconazole


    Sirolimus must be dosed carefully by trained healthcare professionals. Do not ever change the formulation that you are using without consulting your physician.

    People who take Rapamune have an increased risk of infection and possible development of lymphoma.

    You must have the drug level of Rapamune monitored while taking this drug.

    Side Effects

    Rapamune has many possible side effects, including:

    • Abdominal pain
    • Acne
    • Anemia
    • Arthralgia
    • Chest pain
    • Creatinine increase
    • Diarrhea
    • Dizziness
    • Fever
    • Headache
    • Hypercholesterolemia
    • Hypertension
    • Hypertriglyceridemia
    • Myalgia
    • Nasopharyngitis
    • Nausea
    • Pain
    • Peripheral edema
    • Stomatitis
    • Thrombocytopenia
    • Upper respiratory tract infection
    • Urinary tract infection


    Rapamune [package insert]. Philadelphia, PA: Pfizer; 2017.

    IMPORTANT NOTE: The above information is intended to increase awareness of health information and does not suggest treatment or diagnosis. This information is not a substitute for individual medical attention and should not be construed to indicate that use of the drug is safe, appropriate, or effective for you. See your health care professional for medical advice and treatment.

    Product Code : 9740

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