What is a Generic Drug?

A generic drug is a copy of the brand-name drug with the same dosage, safety, strength, quality, consumption method, performance, and intended use. Before generics become available on the market, the generic company must prove it has the same active ingredients as the brand-name drug and works in the same way and in the same amount of time in the body.

The only differences between generics and their brand-name counterparts is that generics are less expensive and may look slightly different (eg. different shape or color), as trademarks laws prevent a generic from looking exactly like the brand-name drug.

Generics are less expensive because generic manufacturers don't have to invest large sums of money to develop a drug. When the brand-name patent expires, generic companies can manufacture a copy of the brand-name and sell it at a substantial discount.

Revolution Plus (Monthly) (Selamectin / Sarolaner Topical Solution)

Also Known as Stronghold Plus


Revolution Plus (Monthly) (Selamectin / Sarolaner Topical Solution)

Prescription Required

Cat Small 2.8-5.5lbs (Less than 2.5kg) (Gold Box)
Cat Medium 5.6-11lbs (2.5-5kg) (Orange Box)
Cats Large 11.1-22lbs (5-10kg) (Green Box)

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  • Product Details


    Revolution Plus is for use in cats only by or on the order of a licensed veterinarian.

    Revolution Plus (selamectin and sarolaner topical solution) is used to treat heartworm disease, fleas, ticks, ear mites, roundworms, and intestinal hookworms in cats and kittens that are at least 8 weeks old and weigh at least 2.8 pounds.

    Revolution Plus is also used to prevent heartworm disease and fleas in cats and kittens that are at least 8 weeks old and weigh at least 2.8 pounds.

    Fact Table


    C43H63NO11 (Selamectin), C23H18Cl2F4N2O5S (Sarolaner)


    US DailyMed


    Not Aavailable

    Legal status


    Chemical Name

    Selamectin / Sarolaner

    Elimination half-life

    2 h

    Dosage (Strength)

    Cat Small 2.8-5.5lbs (Less than 2.5kg) (Gold Box), Cat Medium 5.6-11lbs (2.5-5kg) (Orange Box), Cats Large 11.1-22lbs (5-10kg) (Green Box)


    Consult Doctor


    Revolution Plus

    Protein binding

    Not Available

    PubChem CID



    Not Assigned


    Not Assigned

    ATC code






    Routes of administration

    Topical Solution


    Follow the instructions that come with your cat's prescription. Be sure to discuss your cat's treatment schedule with your veterinarian. If you have any questions, talk to your veterinarian. 

    Revolution Plus for cats is a topical solution that comes in single dose tubes.

    Store Revolution Plus at temperatures below 86°F (30°C).

    Revolution Plus should be applied to dry, intact skin on the back of your cat's neck. 

    Press down on the cap of the tube to break the seal which is indicated by a clicking sound. Take off the cap and make sure the tip of the tube is open. Part the fur on the back of your cat's neck at the base in front of the shoulder blades. Keep parting the fur until you see skin. Position the tip of the tube onto the skin. Squeeze the tube a few times to ensure that all of the liquid solution is applied directly onto the skin. Do not touch the medication. Avoid massaging the medication into the skin. Dispose of empty tubes.

    Your cat's fur may become stiff, clumpy, discolored, or a powdery residue may be seen after applying Revolution Plus. These will go away and will not affect how well the medication works. 


    Weight of cat (pounds)

    Color of cap on the tube

    Tube volume (mL)

    Tube contents: selamectin (mg/tube)

    Tube contents: sarolaner (mg/tube)

    2.8 - 5.5





    5.6 - 11





    11.1 - 22*





    *Cats weighing more than 22 pounds should be treated with the appropriate combination of tubes.


    Selamectin and sarolaner are the active ingredients in Revolution Plus. 


    • Before starting Revolution Plus, talk to your veterinarian about your cat's:
      • Allergies
      • Health problems
      • Medications
      • Pregnancy or nursing status
    • Do not use Revolution Plus in humans. Keep the medication away from children.
    • Sarolaner, one of the active ingredients in Revolution Plus, is known to possibly cause neurological effects in cats such as tremors, coordination problems, and seizures. These effects can happen in cats that have not experienced neurological problems. If your cat has a history of these effects, use caution with Revolution Plus.

    Side Effects

    Revolution Plus can cause side effects including tiredness, skin lesions, anorexia, itching, conjunctivitis, sneezing, hair loss, and scabs. These are not all the side effects that can occur with Revolution Plus. Monitor your cat for any bothersome or persistent side effects and call your veterinarian immediately if they occur.


    1. Revolution Plus (selamectin and sarolaner topical solution). Kalamazoo, MI: Zoetis; 2018.

    IMPORTANT NOTE: The above information is intended to increase awareness of health information and does not suggest treatment or diagnosis. This information is not a substitute for individual medical attention and should not be construed to indicate that use of the drug is safe, appropriate, or effective for you. See your health care professional for medical advice and treatment.

    Product Code : 13211

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