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A generic drug is a copy of the brand-name drug with the same dosage, safety, strength, quality, consumption method, performance, and intended use. Before generics become available on the market, the generic company must prove it has the same active ingredients as the brand-name drug and works in the same way and in the same amount of time in the body.
The only differences between generics and their brand-name counterparts is that generics are less expensive and may look slightly different (eg. different shape or color), as trademarks laws prevent a generic from looking exactly like the brand-name drug.
Generics are less expensive because generic manufacturers don't have to invest large sums of money to develop a drug. When the brand-name patent expires, generic companies can manufacture a copy of the brand-name and sell it at a substantial discount.
Rexulti (Brexpiprazole)
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Product Details
Description
Rexulti (brexpiprazole) is classified as an atypical antipsychotic used as an adjunctive therapy to antidepressants to treat major depressive disorder (MDD) in adults and for the treatment of schizophrenia in adults and pediatric patients who are at least 13 years old.
Rexulti is available in 0.25 mg, 0.5 mg, 1 mg, 2 mg, 3 mg, and 4 mg tablets.
Fact Table
Formula
C25H27N3O2S
License
US DailyMed, EU EMA, US FDA
Bioavailability
95%
Legal status
Rx-Only
Chemical Name
Brexpiprazole
Elimination half-life
91 hours
Dosage (Strength)
0.25mg - 4mg
Pregnancy
Consult Doctor
Brands
Rexulti
Protein binding
Greater than 99%
PubChem CID
11978813
MedlinePlus
a615046
ChEBI
134716
ATC code
N05AX16
DrugBank
DB09128
KEGG
D10309
Routes of administration
By mouth
Directions
Rexulti is taken by mouth once daily with or without food.
MDD in adults
Starting dose: 0.5 mg/day or 1 mg/day
Recommended dose: 2 mg/day
Max dose: 3 mg/day
Schizophrenia in adults
Starting dose: 1 mg/day
Recommended dose: 2 to 4 mg/day
Max dose: 4 mg/day
Schizophrenia in pediatric patients (13-17 years old)
Starting dose: 0.5 mg/day
Recommended dose: 2 to 4 mg/day
Max dose: 4 mg/day
Ingredients
The active ingredient in Rexulti is Brexpiprazole.
Contraindications
Do not take Rexulti if you are allergic to Brexpiprazole or any of the other ingredients in Rexulti. Discuss your allergies with your doctor.
Cautions
WARNING: INCREASED MORTALITY IN ELDERLY PATIENTS WITH DEMENTIA-RELATED PSYCHOSIS and SUICIDAL THOUGHTS AND BEHAVIORS
See full prescribing information for complete boxed warning.
- Elderly patients with dementia-related psychosis treated with antipsychotic drugs are at increased risk of death. REXULTI is not approved for the treatment of patients with dementia-related psychosis.
- Antidepressants increased the risk of suicidal thoughts and behaviors in patients aged 24 years and younger. Monitor for clinical worsening and emergence of suicidal thoughts and behaviors. Safety and effectiveness of REXULTI have not been established in pediatric patients with MDD.
Once you are prescribed and buy Rexulti, Rexulti may cause neuroleptic malignant syndrome that can cause death. Seek medical care right away if you develop a high fever, breathing problems, blood pressure changes, changes in heart rate, stiff muscles, confusion, or sweating.Rexulti can cause uncontrolled movements of your face, tongue, or other parts of the body, even after you stop taking it.
Tell your doctor if you have diabetes. Rexulti can cause high blood sugar. Contact your doctor if you have excessive thirst or hunger, feel sick to your stomach, need to urinate more frequently, feel weak or tired, feel confused, or your breath smells fruity.
Rexulti can cause increased cholesterol and triglycerides.
This medication can cause weight gain. You should monitor your weight while being treated with Rexulti.
Rexulti can cause compulsive urges. Talk to your doctor if you have unusual urges.
Rexulti can cause low white blood cell counts.
Tell your doctor if you have blood pressure problems. Rexulti can cause a sudden drop in your blood pressure upon standing.
This medication can make you feel sleepy or dizzy, cause your blood pressure to drop, or slow your thinking and motor skills that can cause you to fall and develop fractures or other injuries.
Tell your doctor if you have seizures. Rexulti can increase your risk for seizures.
Tell your doctor about any medications you take, including prescription and over-the-counter.
Side Effects
The most common Rexulti side effects include:
- Restless
- Weight gain
These are not all the possible Rexulti side effects, so be sure to tell your doctor right away if you experience bothersome side effects or side effects that persist.References:
- Rexulti Prescribing Information. Rockville, MD: Otsuka America Pharmaceutical, Inc.; 2021.
- Rexulti Important Safety Information. Accessed January 4, 2022.
Frequently Asked Questions about Rexulti (Brexpiprazole)
What is Rexulti (Brexpiprazole) used for?
Schizophrenia: Helps manage symptoms like delusions, hallucinations, and disorganized thinking.
Major depressive disorder (MDD): Used in combination with antidepressants to improve mood and decrease depressive symptoms.
How does Rexulti work?
Rexulti belongs to a class of medications called atypical antipsychotics. It works by affecting the activity of dopamine and serotonin, two brain chemicals involved in mood, thought, and behavior.
What is the dosage of Rexulti?
The dosage varies depending on the condition being treated. It typically starts low and is gradually increased until the desired effect is achieved. It's crucial to follow your doctor's specific instructions.
Can I take Rexulti with other medications?
It's crucial to tell your doctor about all the medications and supplements you take, as Rexulti can interact with some of them.
Is Rexulti addictive?
There is no evidence that Rexulti is addictive. However, it's important to take it exactly as prescribed and not stop taking it suddenly without consulting your doctor.
Is Rexulti safe for pregnant or breastfeeding women?
There is limited data on the safety of Rexulti during pregnancy or breastfeeding. Talk to your doctor about the risks and benefits before taking it if you are pregnant or breastfeeding.
How long does it take for Rexulti to work?
It can take several weeks for Rexulti to reach its full effect. Be patient and continue taking your medication as prescribed even if you don't see immediate results.
What should I do if I miss a dose of Rexulti?
If you miss a dose, take it as soon as you remember. However, if it's close to the time for your next dose, skip the missed dose and continue with your regular schedule. Do not take a double dose.
IMPORTANT NOTE: The above information is intended to increase awareness of health information and does not suggest treatment or diagnosis. This information is not a substitute for individual medical attention and should not be construed to indicate that use of the drug is safe, appropriate, or effective for you. See your health care professional for medical advice and treatment.Product Code : 13234
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