What is a Generic Drug?

A generic drug is a copy of the brand-name drug with the same dosage, safety, strength, quality, consumption method, performance, and intended use. Before generics become available on the market, the generic company must prove it has the same active ingredients as the brand-name drug and works in the same way and in the same amount of time in the body.

The only differences between generics and their brand-name counterparts is that generics are less expensive and may look slightly different (eg. different shape or color), as trademarks laws prevent a generic from looking exactly like the brand-name drug.

Generics are less expensive because generic manufacturers don't have to invest large sums of money to develop a drug. When the brand-name patent expires, generic companies can manufacture a copy of the brand-name and sell it at a substantial discount.

Rheumate (L-5,Curcumin,Vitamin b-12)


Rheumate (L-5,Curcumin,Vitamin b-12)

Prescription Required


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  • Product Details


    Your doctor may prescribe Rheumate for nutritional support if you use the drug methotrexate. Methotrexate is a medication that treats various conditions, including conditions where the immune system is overactive. It works by blocking folic acid, which is required for cell replication.

    Methotrexate is very effective, but blocking folic acid also negatively affects healthy cells. Therefore, it is critical to replenish folate (vitamin B9) when taking methotrexate.

    Rheumate is a medical food and not a prescription drug. It requires the supervision of a trained medical professional for usage and cannot be purchased over-the-counter.


    The starting dosage is one capsule by mouth once daily. It can be increased to two capsules by mouth up to twice daily.


    There are three active ingredients in Rheumate, including folate (vitamin B9 as L-5-methyltetrahydrofolic acid), methylcobalamin (vitamin B12), and curcuminoid turmerone complex (turmeric).

    Folate protects healthy cells from damage that would happen during methotrexate therapy. This form of folate can be used by people with methyltetrahydrofolate reductase (MTHFR) deficiency who cannot take other forms of vitamin B9.

    When taking folate supplements, it can mask the symptoms of anemia caused by vitamin B12 deficiency. Vitamin B12 is included in Rheumate to ensure adequate B12 for a healthy metabolism.

    Turmeric is an antioxidant that scavenges reactive oxygen species (ROS) and protects the liver from damage by methotrexate. 


    Common drug interactions with Rheumate can include:

    • Atorvastatin
    • Fluvastatin
    • Lovastatin
    • Oral contraceptives
    • Phenytoin
    • Pravastatin
    • Pitavastatin
    • Rosuvastatin
    • Simvastatin
    • Sulfasalazine
    • Tetracycline
    • Warfarin


    Do not take Rheumate if you have a hypersensitivity (allergy) to any of the ingredients.

    Oral contraceptives pills can decrease the amount of vitamin B9 in the blood and increase the risk of treatment failure unless the dose of Rheumate is adjusted.

    Side Effects

    Adverse reactions are rare, but the most common include:4


    Rheumate. Scottsdale, AZ: Primus Pharmaceuticals, Inc.; 2016.

    IMPORTANT NOTE: The above information is intended to increase awareness of health information and does not suggest treatment or diagnosis. This information is not a substitute for individual medical attention and should not be construed to indicate that use of the drug is safe, appropriate, or effective for you. See your health care professional for medical advice and treatment.

    Product Code : 13624

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