What is a Generic Drug?
A generic drug is a copy of the brand-name drug with the same dosage, safety, strength, quality, consumption method, performance, and intended use. Before generics become available on the market, the generic company must prove it has the same active ingredients as the brand-name drug and works in the same way and in the same amount of time in the body.
The only differences between generics and their brand-name counterparts is that generics are less expensive and may look slightly different (eg. different shape or color), as trademarks laws prevent a generic from looking exactly like the brand-name drug.
Generics are less expensive because generic manufacturers don't have to invest large sums of money to develop a drug. When the brand-name patent expires, generic companies can manufacture a copy of the brand-name and sell it at a substantial discount.
Rhofade (Oxymetazoline HCI)
Prescription Required
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Product Details
Description
Rhofade is a prescription cream for topical use on the face. It is indicated for the treatment of persistent facial erythema associated with rosacea.
Rosacea is a condition where someone has small red bumps on their face. It is more common in middle-aged women with fair skin. Without treatment, rosacea usually gets worse with time.
Rhofade works by constricting blood flow to the area. Slowing and preventing blood flow helps to relieve symptoms of rosacea.
Fact Table
Formula
C16H24N2O
License
US FDA
Bioavailability
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Legal status
Rx-Only (topical cream)
Chemical Name
Oxymetazoline
Elimination half-life
5–6 hours
Dosage (Strength)
1%
Pregnancy
No Known Risks
Brands
Afrin, Ocuclear, Drixine, Rhofade
Protein binding
56.7% to 57.5%
PubChem CID
4636
MedlinePlus
a617018
ChEBI
7862
ATC code
D11AX27
DrugBank
DB00935
KEGG
D08322
Routes of administration
Topical
Directions
Apply a pea-sized amount to the affected area. Rhofade is usually applied to the entire face area while avoiding the eyes and lips.
Wash hands thoroughly after using.
Prime the bottle when using it for the first time by pumping three times.
Do not apply the medication to the mouth, eyes, or vagina.
Ingredients
The active ingredient in Rhofade is oxymetazoline.
Interactions
In general, drug interactions are rare with topical medications like Rhofade because only small amounts absorb into the bloodstream. However, when taken in high doses or for long periods, the risk of drug interactions can increase.
Tell your doctor and pharmacist if you are taking any of the following medications:
- Bromocriptine
- Cocaine (topical)
- Ergot derivatives
- Esketamine
- Iobenguane radiopharmaceutical products
- Kratom
- Linezolid
- Lisuride
- Monoamine oxidase inhibitors
Cautions
Use caution if you have a history of high blood pressure or other heart conditions like cardiovascular disease or orthostatic hypotension. Rhofade can constrict blood vessels and affect the cardiovascular system if absorbed into the circulation.
Use caution if you have a history of Raynaud's phenomenon, scleroderma, Sjogren's syndrome, or thromboangiitis obliterans.
Use caution if you have a history of narrow-angle glaucoma.
Side Effects
The most common side effects of this drug can include:
- Application site dermatitis
- Application site erythema
- Application site pain
- Exacerbation of acne rosacea
References
Rhofade cream. Irvine, CA: Allergan; 2017.
IMPORTANT NOTE: The above information is intended to increase awareness of health information and does not suggest treatment or diagnosis. This information is not a substitute for individual medical attention and should not be construed to indicate that use of the drug is safe, appropriate, or effective for you. See your health care professional for medical advice and treatment.Product Code : 13623
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