What is a Generic Drug?

A generic drug is a copy of the brand-name drug with the same dosage, safety, strength, quality, consumption method, performance, and intended use. Before generics become available on the market, the generic company must prove it has the same active ingredients as the brand-name drug and works in the same way and in the same amount of time in the body.

The only differences between generics and their brand-name counterparts is that generics are less expensive and may look slightly different (eg. different shape or color), as trademarks laws prevent a generic from looking exactly like the brand-name drug.

Generics are less expensive because generic manufacturers don't have to invest large sums of money to develop a drug. When the brand-name patent expires, generic companies can manufacture a copy of the brand-name and sell it at a substantial discount.

Rhofade (Oxymetazoline HCI)


Rhofade (Oxymetazoline HCI)

Prescription Required

1% Cream

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  • Product Details


    Rhofade is a prescription cream for topical use on the face. It is indicated for the treatment of persistent facial erythema associated with rosacea.

    Rosacea is a condition where someone has small red bumps on their face. It is more common in middle-aged women with fair skin. Without treatment, rosacea usually gets worse with time.

    Rhofade works by constricting blood flow to the area. Slowing and preventing blood flow helps to relieve symptoms of rosacea.

    Fact Table




    US FDA



    Legal status

    Rx-Only (topical cream)

    Chemical Name


    Elimination half-life

    5–6 hours

    Dosage (Strength)



    No Known Risks


    Afrin, Ocuclear, Drixine, Rhofade

    Protein binding

    56.7% to 57.5%

    PubChem CID






    ATC code






    Routes of administration



    Apply a pea-sized amount to the affected area. Rhofade is usually applied to the entire face area while avoiding the eyes and lips. 

    Wash hands thoroughly after using.

    Prime the bottle when using it for the first time by pumping three times.

    Do not apply the medication to the mouth, eyes, or vagina.


    The active ingredient in Rhofade is oxymetazoline.


    In general, drug interactions are rare with topical medications like Rhofade because only small amounts absorb into the bloodstream. However, when taken in high doses or for long periods, the risk of drug interactions can increase.

    Tell your doctor and pharmacist if you are taking any of the following medications:

    • Bromocriptine
    • Cocaine (topical)
    • Ergot derivatives
    • Esketamine
    • Iobenguane radiopharmaceutical products 
    • Kratom
    • Linezolid
    • Lisuride
    • Monoamine oxidase inhibitors


    Use caution if you have a history of high blood pressure or other heart conditions like cardiovascular disease or orthostatic hypotension. Rhofade can constrict blood vessels and affect the cardiovascular system if absorbed into the circulation.

    Use caution if you have a history of Raynaud's phenomenon, scleroderma, Sjogren's syndrome, or thromboangiitis obliterans.

    Use caution if you have a history of narrow-angle glaucoma.

    Side Effects

    The most common side effects of this drug can include:

    • Application site dermatitis
    • Application site erythema
    • Application site pain
    • Exacerbation of acne rosacea


    Rhofade cream. Irvine, CA: Allergan; 2017.

    IMPORTANT NOTE: The above information is intended to increase awareness of health information and does not suggest treatment or diagnosis. This information is not a substitute for individual medical attention and should not be construed to indicate that use of the drug is safe, appropriate, or effective for you. See your health care professional for medical advice and treatment.

    Product Code : 13623

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