A generic drug is a copy of the brand-name drug with the same dosage, safety, strength, quality, consumption method, performance, and intended use. Before generics become available on the market, the generic company must prove it has the same active ingredients as the brand-name drug and works in the same way and in the same amount of time in the body.
The only differences between generics and their brand-name counterparts is that generics are less expensive and may look slightly different (eg. different shape or color), as trademarks laws prevent a generic from looking exactly like the brand-name drug.
Generics are less expensive because generic manufacturers don't have to invest large sums of money to develop a drug. When the brand-name patent expires, generic companies can manufacture a copy of the brand-name and sell it at a substantial discount.
Rinvoq ER (Upadacitinib)
Brand
Rinvoq ER (Upadacitinib)
Prescription Required
Strength
Qty
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Your doctor may prescribe Rinvoq for severe active rheumatoid arthritis if you have already tried and failed other medications like methotrexate. Rinvoq is sometimes given along with methotrexate and other medications for rheumatoid arthritis.
Rheumatoid arthritis is an autoimmune disorder where the immune system attacks the joints, including the hands, knees, and feet. Symptoms include pain, stiffness, tenderness, and swelling in the joints.
Rinvoq works by decreasing the activity of the immune system. By lowering the activity of the immune system, Rinvoq decreases symptoms of rheumatoid arthritis.
Fact Table
Formula
C17H19F3N6O
License
US FDA, EU EMA
Bioavailability
80%
Legal status
Rx-only
Chemical Name
Upadacitinib
Elimination half-life
9–14 hours
Dosage (Strength)
15mg
Pregnancy
Not Recommended
Brands
Rinvoq ER
Protein binding
52%
PubChem CID
58557659
MedlinePlus
a619051
ChEBI
-
ATC code
L04AA44
DrugBank
DB15091
KEGG
D10994
Routes of administration
By mouth
Directions
The usual Rinvoq dosing is 15 mg by mouth once daily.
Ingredients
The active ingredient in Rinvoq is upadacitinib.
Interactions
Tell your doctor or pharmacist if you are taking any of the following before starting Rinvoq:
Apalutamide
Atazanavir
Carbamazepine
Ceritinib
Clarithromycin
Darunavir
Enzalutamide
Fosphenytoin
Idelalisib
Indinavir
Itraconazole
Ketoconazole
Lonafarnib
Lopinavir
Lumacaftor
Lumacaftor-ivacaftor
Mifepristone
Mitotane
Nefazodone
Nelfinavir
Ombitasvir-paritaprevir-ritonavir
Phenobarbital
Phenytoin
Posaconazole
Primidone
Rifampin (rifampicin)
Saquinavir
Telithromycin
Tucatinib
Voriconazole
Cautions
Rinvoq should not be used with biologic DMARDs or potent immunosuppressants like cyclosporine and azathioprine.
Some patients are at higher risk of developing serious infections while taking Rinvoq.
Tell your doctor if you have a history of latent tuberculosis infection.
Drugs like Rinvoq can increase the likelihood of blood clots and certain cancers like lymphoma.
Do not receive live vaccinations while taking Rinvoq.
Side Effects
Some of the common adverse reactions to Rinvoq may include:
IMPORTANT NOTE:
The above information is intended to increase awareness of health information and does not suggest treatment or diagnosis. This information is not a substitute for individual medical attention and should not be construed to indicate that use of the drug is safe, appropriate, or effective for you. See your health care professional for medical advice and treatment.
Prescription Required
