Ryzodeg (Insulin)

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  • Product Details


    RYZODEG (insulin degludec and insulin aspart) is a drug prescribed to improve blood glucose control in diabetes mellitus. RYZODEG is an insulin product that lowers blood sugar to normal levels.

    People with diabetes may have blood sugar that is too high (hyperglycemia) or too low (hypoglycemia). Insulin products can treat hyperglycemia.

    RYZODEG contains two different types of insulin: basal insulin and mealtime insulin. RYZODEG is good for people that want to reduce the number of insulin injections they have per day.


    Inject RYZODEG 70/30 subcutaneously once or twice daily with the largest meal(s) of the day. Rotate injection sites to decrease the risk of lipodystrophy and localized cutaneous amyloidosis.

    The dosage of RYZODEG 70/30 will be determined by the doctor.


    RYZODEG contains 70% insulin degludec, long-acting basal insulin. It also contains 30% insulin aspart, mealtime insulin with a fast onset.


    Some medications can mask the signs and symptoms of hypoglycemia. Use caution when taking the following with insulin:

    • Beta-blockers
    • Clonidine
    • Guanethidine
    • Reserpine

    Certain medications can raise or lower blood sugar. Tell your doctor or pharmacist if you are taking any of the following:

    • Alcohol
    • Atypical Antipsychotics
    • Corticosteroids
    • Disopyramide
    • Diuretics
    • Estrogens/Progesterones
    • Fibrates
    • Fluoxetine
    • Isoniazid
    • Lithium
    • Monoamine Oxidase Inhibitors (MAOIs)
    • Niacin
    • Oral antidiabetic agents
    • Pentoxifylline
    • Phenothiazine derivatives
    • Pramlintide
    • Propoxyphene
    • Protease inhibitors
    • Salicylates
    • Somatostatin Analogues
    • Somatropin
    • Sulfonamide Antibiotics
    • Sympathomimetic agents
    • Thyroid replacement medication


    The dosage of RYZODEG injection should not be adjusted more often than 3 to 4 days.

    RYZODEG cannot be mixed with other insulin products.

    Do not share insulin pens between patients, even if the pen needle is changed.

    Blood sugar should be frequently monitored while taking insulin.

    Check the product label before administration to reduce the risk of medication errors.

    Your doctor may need to monitor potassium levels, kidney function, and liver function while taking insulin.

    Side Effects

    The most common side effects of RYZODEG 70/30 include:

    • Allergic reactions
    • Edema
    • Hypoglycemia
    • Injection site reactions
    • Lipodystrophy
    • Pruritis
    • Rash
    • Weight gain


    Ryzodeg 70/30 [package insert]. Plainsboro, NJ: Novo Nordisk; 2019.

    IMPORTANT NOTE: The above information is intended to increase awareness of health information and does not suggest treatment or diagnosis. This information is not a substitute for individual medical attention and should not be construed to indicate that use of the drug is safe, appropriate, or effective for you. See your health care professional for medical advice and treatment.

    Product Code : 13376

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