What is a Generic Drug?
A generic drug is a copy of the brand-name drug with the same dosage, safety, strength, quality, consumption method, performance, and intended use. Before generics become available on the market, the generic company must prove it has the same active ingredients as the brand-name drug and works in the same way and in the same amount of time in the body.
The only differences between generics and their brand-name counterparts is that generics are less expensive and may look slightly different (eg. different shape or color), as trademarks laws prevent a generic from looking exactly like the brand-name drug.
Generics are less expensive because generic manufacturers don't have to invest large sums of money to develop a drug. When the brand-name patent expires, generic companies can manufacture a copy of the brand-name and sell it at a substantial discount.
Siklos (Hydroxyurea)
Prescription Required
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Product Details
Description
Siklos is prescribed to treat painful crises in people with sickle cell anemia who are two years of age or older. Sickle cell anemia is a disease of the red blood cells that cause them to be misshaped. Siklos works through several mechanisms to help restore red blood cells' proper functioning and shape.
Fact Table
Formula
CH4N2O2
License
US FDA, EU EMA
Bioavailability
79%
Legal status
Rx-only
Chemical Name
Hydroxyurea
Elimination half-life
2–4 hours
Dosage (Strength)
100mg
Pregnancy
Consult Doctor
Brands
Medunik
Protein binding
More than 76%
PubChem CID
3657
MedlinePlus
a682004
ChEBI
44423
ATC code
L01XX05
DrugBank
DB01005
KEGG
D00341
Routes of administration
By mouth
Directions
The starting dosage is 20 mg per kilogram and may be increased as needed. If bone marrow suppression occurs, Siklos should be discontinued until blood counts return to an acceptable range.
Do not stop taking Sikos or change the dose without speaking with your doctor.
Ingredients
The active ingredient is hydroxyurea.
Siklos is available in 1000 mg and 100 mg tablets.
Interactions
Tell your pharmacist and doctor about all drugs you are taking before starting Siklos. Common interactions may include:
- Abrocitinib
- Baricitnib
- BCG (Intravesical)
- Cladribine
- Dengue tetravalent vaccine
- Didanosine
- Dipyrone
- Fexinidazole
- Natalizumab
- Pimecrolimus
- Poliovirus vaccine
- Rubella vaccine
- Ruxolitinib
- Stavudine
- Tacrolimus
- Talimogene
- Tertomotide
- Tofacitinib
- Typhoid vaccine
- Upadacitinib
- Varicella vaccine
- Yellow fever vaccine
Cautions
The dose must be adjusted if you have a history of kidney problems or kidney impairment.
Avoid the sun or wear appropriate protective clothing and sunscreen while taking this drug.
The healthcare team should carefully monitor bone marrow function while taking this drug.
Siklos is harmful to a developing fetus. Use appropriate contraception while taking this drug.
Side Effects
Siklos can cause the following adverse reactions:
- Acute mucocutaneous toxicity
- Alopecia
- Anemia
- Arthralgia
- Asthenia
- Asthma
- Back pain
- Bacterial infection
- Bone marrow depression
- Bronchitis
- Constipation
- Cough
- Dermal ulcer
- Dermatological reaction
- Diarrhea
- Disorder of urinary system
- Dizziness
- Dyspnea
- Eczema
- Fatigue
- Fever
- Headache
- Hemorrhage
- Influenza
- Leg ulcer
- Leukopenia
- Limb pain
- Macrocytosis
- Nasopharyngitis
- Nausea
- Neutropenia
- Peripheral edema
- Pulmonary disease
- Renal disease
- Severe nervous system disease
- Skin depigmentation
- Thrombocytopenia
- Upper abdominal pain
- Urinary tract infection
- Viral infection
- Vitamin D deficiency
- Weight gain
- Xeroderma
References
Siklos. Bryn Mawr, PA: Medunik USA, Inc; 2017.
IMPORTANT NOTE: The above information is intended to increase awareness of health information and does not suggest treatment or diagnosis. This information is not a substitute for individual medical attention and should not be construed to indicate that use of the drug is safe, appropriate, or effective for you. See your health care professional for medical advice and treatment.Product Code : 13625
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