What is a Generic Drug?

A generic drug is a copy of the brand-name drug with the same dosage, safety, strength, quality, consumption method, performance, and intended use. Before generics become available on the market, the generic company must prove it has the same active ingredients as the brand-name drug and works in the same way and in the same amount of time in the body.

The only differences between generics and their brand-name counterparts is that generics are less expensive and may look slightly different (eg. different shape or color), as trademarks laws prevent a generic from looking exactly like the brand-name drug.

Generics are less expensive because generic manufacturers don't have to invest large sums of money to develop a drug. When the brand-name patent expires, generic companies can manufacture a copy of the brand-name and sell it at a substantial discount.

Simparica Trio (Sarolaner, Moxidectin, Pyrantel)


Simparica Trio (Sarolaner, Moxidectin, Pyrantel)

Prescription Required

Dog 2.8-5.5 lbs (Gold Box)
Dog 5.6-11 lbs (Purple Box)
Dog 11.1-22 lbs (Caramel Box)
Dog 22.1-44 lbs (Teal Box)
Dog 44.1-88 lbs (Green Box)
Dog 88.1-132 lbs (Brown Box)

You'll have option to make 4 interest-free payments by credit card once your order is confirmed using Sezzle

We don't have this generic product yet!

Sign up to get exclusive coupon discounts and be the first to be notified when we have this product available.

  • Product Details


    Simparica TRIO (sarolaner, moxidectin, and pyrantel) is an oral medication for dogs that are at least 8 weeks old and weigh at least 2.8 pounds. It's a flavored, chewable tablet used by or on the order of a licensed veterinarian to:

    • Prevent heartworm disease
    • Treat roundworms and hookworms
    • Prevent and treat fleas
    • Treat ticks
    • Prevent Borrelia burgdorferi infections caused by the killing of Ixodes scapularis vector ticks

    Fact Table


    C23H18Cl2F4N2O5S(Sarolaner), C37H53NO8(Moxidectin), C11H14N2S(Pyrantel)


    US FDA


    poorly absorbed

    Legal status


    Chemical Name

    Sarolaner, Moxidectin, Pyrantel

    Elimination half-life

    Not Available

    Dosage (Strength)

    Dog 2.8-5.5 lbs (Gold Box), Dog 5.6-11 lbs (Purple Box), Dog 11.1-22 lbs (Caramel Box), Dog 22.1-44 lbs (Teal Box), Dog 44.1-88 lbs (Green Box), Dog 88.1-132 lbs (Brown Box)


    Pet Drug


    Simparica Trio

    Protein binding

    Not Available

    PubChem CID



    Not Assigned



    ATC code



    Not Assigned



    Routes of administration

    By mouth


    Be sure to follow your veterinarian's instructions on administering Simparica TRIO to your dog. Don't hesitate to ask your veterinarian questions or inform them of any concerns you may have. 

    Simparica TRIO is administered by mouth one time a month. It may be given with or without food. Your veterinarian will recommend an appropriate dose for your dog based on your dog's body weight. 


    Sarolaner, moxidectin, and pyrantel are the three active ingredients contained in each tablet of Simparica TRIO. 


    • Before you administer Simparica TRIO to your dog, be sure you discuss the following with your veterinarian:
      • Your dog's medications
      • Your dog's allergies
      • Your dog's health conditions
      • If your dog is pregnant or may be pregnant
      • If your dog is nursing
    • Simparica TRIO should not be administered to humans, cats, or other animals.
    • Neurological effects such as tremors, coordination problems, and seizures have been associated with the use of sarolaner, an active ingredient in Simparica TRIO. If your dog has a history of seizures or neurologic problems, use Simparica TRIO with caution.

    Side Effects

    Simparica TRIO side effects include vomiting, diarrhea, lack of energy, decreased appetite, excessive urination, hyperactivity, and excessive thirst. If your dog develops side effects that concern you, contact your veterinarian right away.


    Simparica TRIO (sarolaner, moxidectin, and pyrantel chewable tablets). Kalamazoo, MI: Zoetis Inc.; 2022.

    IMPORTANT NOTE: The above information is intended to increase awareness of health information and does not suggest treatment or diagnosis. This information is not a substitute for individual medical attention and should not be construed to indicate that use of the drug is safe, appropriate, or effective for you. See your health care professional for medical advice and treatment.

    Product Code : 13508

  • Product Reviews


Please wait while the page is loading. Do not hit refresh or the browser back button to avoid any loss of information.

If you have any questions or concerns, please contact our Customer Service team via the chat option on our website or calling us toll free at: 1-800-891-0844