What is a Generic Drug?
A generic drug is a copy of the brand-name drug with the same dosage, safety, strength, quality, consumption method, performance, and intended use. Before generics become available on the market, the generic company must prove it has the same active ingredients as the brand-name drug and works in the same way and in the same amount of time in the body.
The only differences between generics and their brand-name counterparts is that generics are less expensive and may look slightly different (eg. different shape or color), as trademarks laws prevent a generic from looking exactly like the brand-name drug.
Generics are less expensive because generic manufacturers don't have to invest large sums of money to develop a drug. When the brand-name patent expires, generic companies can manufacture a copy of the brand-name and sell it at a substantial discount.
Sprycel (Dasatinib)
Prescription Required
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Product Details
Description
Sprycel is a prescription medication used to treat chronic myeloid leukemia (CML) and Philadelphia chromosome-positive acute lymphoblastic leukemia (Ph+ ALL).
Chronic myeloid leukemia is a type of blood cancer characterized by an overproduction of abnormal white blood cells.
This medication is part of a class of tyrosine kinase inhibitors, effectively targeting the genetic mutations responsible for CML. Sprycel acts by inhibiting the abnormal proteins produced by the BCR-ABL gene, thus slowing the proliferation of malignant cancer cells.
Directions
The usual dosage is 100 mg or 140 mg daily, depending on the condition being treated.
Ingredients
The active ingredient in Sprycel is dasatinib.
Interactions
Common drug-drug interactions may include:
- 5-Aminosalicylic Acid Derivatives
- Abrocitinib
- Acetaminophen
- Antiplatelets
- Amisulpride (Oral)
- Androgens
- Antacids
- Anticoagulants
- Antithymocyte Globulin (Equine)
- Azithromycin (Systemic)
- Baricitinib
- BCG (Intravesical)
- BCG Products
- Brincidofovir
- Brivudine
- Chloramphenicol (Ophthalmic)
- Cladribine
- Clofazimine
- CloZAPine
- Coccidioides immitis Skin Test
- COVID-19 Vaccine
- Dabrafenib
- Deferiprone
- Dengue Tetravalent Vaccine (Live)
- Denosumab
- Deucravacitinib
- Dipyrone
- Domperidone
- Fexinidazole
- Filgotinib
- Fluorouracil Products
- Fusidic Acid (Systemic)
- Grapefruit Juice
- Haloperidol
- Histamine H2 Receptor Antagonists
- Inebilizumab
- Influenza Virus Vaccines
- Inhibitors of the Proton Pump (PPIs and PCABs)
- Lefamulin
- Leflunomide
- Levoketoconazole
- Midostaurin
- Mumps- Rubella- or Varicella-Containing Live Vaccines
- Natalizumab
- Ocrelizumab
- Ofatumumab
- OLANZapine
- Olaparib
- Ondansetron
- PAZOPanib
- Pentamidine (Systemic)
- Pidotimod
- Pimecrolimus
- Pimozide
- Pneumococcal Vaccines
- Poliovirus Vaccine (Live/Trivalent/Oral)
- Posaconazole
- Promazine
- Propacetamol
- QT-prolonging Agents
- Rabies Vaccine
- RisperiDONE
- Ritlecitinib
- Ropeginterferon Alfa-2b
- Ruxolitinib (Topical)
- Saquinavir
- Sertindole
- Sipuleucel-T
- Solriamfetol
- St John's Wort
- Tacrolimus (Topical)
- Tertomotide
- Tofacitinib
- Typhoid Vaccine
- Ublituximab
- Upadacitinib
- Vaccines (Inactivated/Non-Replicating)
- Vaccines (Live)
- Yellow Fever Vaccine
Cautions
Before starting treatment, tell your doctor if you have a history of kidney problems, liver problems, heart disease, or diseases of the blood cells.
Side Effects
Common side effects can include:
- Abdominal distension
- Abdominal pain
- Acne vulgaris
- Alopecia
- Anemia
- Arthralgia
- Asthenia
- Blurred vision
- Bruise
- Cardiac conduction disturbance
- Cardiac disorder
- Change in appetite
- Chest pain
- Chills
- Colitis
- Constipation
- Cough
- Decreased visual acuity
- Depression
- Dermatitis
- Diarrhea
- Dizziness
- Dry eye syndrome
- Dysgeusia
- Dyspepsia
- Dyspnea
- Edema (1% to 4%)
- Eczema
- Facial edema
- Fatigue
- Fever
- Fluid retention
- Gastrointestinal hemorrhage (2% to 9%)
- Headache
- Herpes virus infection
- Hyperhidrosis
- Hyperuricemia
- Hypocalcemia (grades 3/4)
- Hypokalemia (grades 3/4)
- Hypophosphatemia (grades 3/4)
- Hypertension
- Hypersensitivity
- Increased serum alanine aminotransferase (grades 3/4)
- Increased serum aspartate aminotransferase (grades 3/4)
- Increased serum bilirubin (grades 3/4)
- Increased serum creatinine (grades 3/4)
- Infection
- Insomnia
- Intracranial hemorrhage
- Limb pain
- Localized edema
- Muscle spasm
- Musculoskeletal pain
- Myalgia
- Myasthenia
- Nausea
- Neuropathy
- Otic: Tinnitus
- Pain
- Peripheral edema
- Pleural effusion
- Pneumonia
- Pneumonitis
- Pruritus
- Pulmonary edema
- Pulmonary hypertension
- Pulmonary infiltrates
- Skin rash
- Soft tissue injury (oral)
- Thrombocytopenia
- Vomiting
- Weight gain
- Xeroderma
References
Sprycel [package insert]. City, ST: Pharma; year.
IMPORTANT NOTE: The above information is intended to increase awareness of health information and does not suggest treatment or diagnosis. This information is not a substitute for individual medical attention and should not be construed to indicate that use of the drug is safe, appropriate, or effective for you. See your health care professional for medical advice and treatment.Product Code : 11686
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