What is a Generic Drug?
A generic drug is a copy of the brand-name drug with the same dosage, safety, strength, quality, consumption method, performance, and intended use. Before generics become available on the market, the generic company must prove it has the same active ingredients as the brand-name drug and works in the same way and in the same amount of time in the body.
The only differences between generics and their brand-name counterparts is that generics are less expensive and may look slightly different (eg. different shape or color), as trademarks laws prevent a generic from looking exactly like the brand-name drug.
Generics are less expensive because generic manufacturers don't have to invest large sums of money to develop a drug. When the brand-name patent expires, generic companies can manufacture a copy of the brand-name and sell it at a substantial discount.
Stendra (Avanafil)
Also Known as Spedra
Prescription Required
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Product Details
Description
Stendra (avanafil) is a medication used to treat erectile dysfunction.
Directions
Follow your prescription's instructions and ask your doctor or pharmacist about any questions or concerns you have.
Stendra is available in 50 mg, 100 mg, and 200 mg oral tablets.
Most patients start out taking a dosage of 100 mg by mouth about 30 minutes before sexual activity, as needed. Do not take it more than one time a day. You may take Stendra with or without food.
Do not take Stendra with strong CYP3A4 inhibitors. Ask your doctor if you are unsure whether or not you are taking strong CYP3A4 inhibitors.
Your dose may be adjusted if you are taking moderate CYP3A4 inhibitors. Ask your doctor if you are unsure whether or not you are taking moderate CYP3A4 inhibitors.
Your dose may also be adjusted if you are taking an alpha-blocker. Ask your doctor if you are unsure whether or not you are taking an alpha-blocker.
Ingredients
Avanfil, a phosphodiesterase 5 (PDE5) inhibitor, is the active ingredient contained in each Stendra tablet. The inactive ingredients included in each tablet are mannitol, fumaric acid, hydroxypropylcellulose, low substituted hydroxypropylcellulose, calcium carbonate, magnesium stearate, and ferric oxide yellow.
Fact Table
Formula
C23H26ClN7O3
License
EU EMA, US FDA
Bioavailability
Low to moderate
Legal status
RX Only
Chemical Name
Avanafil
Elimination half-life
5-17 hours
Dosage (Strength)
50mg, 100mg, or 200mg (16 tablets)
Pregnancy
Consult a doctor
Brands
Stendra
Protein binding
81%
PubChem CID
9869929
MedlinePlus
a614010
ChEBI
66876
ATC code
G04BE10
DrugBank
DB06237
KEGG
D03217
Routes of administration
By mouth (tablets)
Contraindications
Do not take Stendra if you are using organic nitrate in any form.
Do not take Stendra if you are allergic to avanafil or any of the other ingredients or excipients contained in Stendra.
Cautions
- Before you start taking Stendra, discuss the following with your doctor:
- Your allergies
- Your health problems
- Any medications you take, including prescription, nonprescription, vitamins, and herbal supplements
- You should not take Stendra if you have been advised to avoid sexual activity due to underlying cardiovascular problems or other reasons.
- Taking Stendra with blood pressure medications or large quantities of alcohol can cause low blood pressure.
- If you have an erection that lasts longer than 4 hours, get emergency care immediately.
- If you experience sudden vision loss in one or both of your eyes, stop taking Stendra and get emergency care immediately. This could be a sign of Non Arteritic Ischemic Optic Neuropathy (NAION). Your risk may be higher if you have had NAION.
- If you experience a decrease in hearing or hearing loss, stop taking Stendra and get emergency care immediately.
Side Effects
Stendra can cause side effects such as headache, flushing, nasal congestion, nasopharyngitis, and back pain. These are not all the side effects that can occur with the use of Stendra. Contact your doctor right away if you experience bothersome or persistent side effects.
Reference:
Stendra (avanafil) tablets, for oral use. Mountain View, CA: Vivus, Inc.; 2012.
IMPORTANT NOTE: The above information is intended to increase awareness of health information and does not suggest treatment or diagnosis. This information is not a substitute for individual medical attention and should not be construed to indicate that use of the drug is safe, appropriate, or effective for you. See your health care professional for medical advice and treatment.Product Code : 13157
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