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Also Known as Spiolto


Stiolto Respimat (Tiotropium Bromide / Olodaterol)

Prescription Required

2.5mcg / 2.5mcg (60 puffs / 30 doses / inhaler)
2.5mcg / 2.5mcg (60 puffs / 30 doses / inhaler)

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  • Product Details


    Stiolto Respimat (tiotropium bromide and olodaterol inhalation spray) is used for long-term maintenance of chronic obstructive pulmonary disease (COPD) in adults.

    Stiolto Respimat contains an anticholinergic, tiotropium bromide, and a long-acting beta2-adrenergic agonist, olodaterol. These are medicines that help open up the muscles around your airways, allowing you to breathe better.

    Stiolto Respimat should not be used for acute deterioration of COPD.

    Stiolto Respimat should not be used to treat asthma.

    Fact Table




    US FDA



    Legal status


    Chemical Name

    Tiotropium Bromide / Olodaterol

    Elimination half-life

    7.5 hours

    Dosage (Strength)

    2.5mcg/2.5mcg (60 puffs/30 doses/inhaler)


    Consult Doctor


    Stiolto Respimat

    Protein binding


    PubChem CID






    ATC code






    Routes of administration



    Be sure to follow your Stiolto Respimat prescription's instructions. Reach out to your doctor or pharmacist if you have any questions or concerns.

    Stiolto Respimat is available in an inhalation spray. Each spray provides 2.5 mcg of tiotropium and 2.5 mcg of olodaterol. 

    The recommended dosage for Stiolto Respimat is to inhale two puffs by mouth once daily. Use at the same time each day.


    The active ingredients in Stiolto Respimat are tiotropium bromide, an anticholinergic, and olodaterol, a long-acting beta2-adrenergic agonist. 

    The inactive ingredients include water for injection, benzalkonium chloride, edetate disodium, and hydrochloric acid.


    Do not use Stiolto Respimat without an inhaled corticosteroid if you have asthma.

    Do not use Stiolto Respimat if you have an allergy to tiotropium, ipratropium, olodaterol, or any ingredient in Stiolto Respimat.


    • Before you begin treatment with Stiolto Respimat, be sure to discuss the following with your doctor:
      • Your allergies
      • Your health problems
      • All the medications you take. These include prescription and over-the-counter medications, as well as vitamins and herbal supplements.
      • If you are pregnant, think you are pregnant, or have plans to become pregnant.
      • If you are breastfeeding or have plans to breastfeed your baby.
    • Stiolto Respimat should not be used in patients who have acutely deteriorating COPD, a serious condition that can be fatal. Talk to your doctor about your COPD.
    • Stiolto Respimat should not be used as a rescue inhaler.
    • Do not use more than the recommended dose of Stiolto Respimat. 
    • Using Stiolto Respimat with other medications that have long-acting beta2-adrenergic agonists can cause serious and potentially life-threatening cardiovascular problems.
    • Stop taking Stiolto Respimat and seek emergency care immediately if you experience swelling, itching, rash, bronchospasm, trouble breathing, or other effects. These could be signs and symptoms of a serious allergic reaction.
    • Stiolto Respimat has the potential to cause paradoxical bronchospasm that may be fatal. 
    • Caution should be used if you have cardiovascular or convulsive problems, thyroid problems, or if you cannot tolerate sympathomimetic drugs. 
    • Stiolto Respimat can worsen glaucoma. Caution should be used if you have glaucoma.
    • Stiolto Respimat can worsen urinary retention. Caution should be used if you have prostatic hyperplasia or bladder-neck obstruction.
    • Stiolto Respimat can cause low potassium and high blood glucose levels. 

    Side Effects

    Nasopharyngitis, cough, and back pain are the most common side effects associated with Stiolto Respimat; however, these are not all the side effects that can occur with its use. Contact your doctor immediately if worsening or continuous side effects occur.


    Stiolto Respimat (tiotropium bromide and olodaterol inhalation spray), for oral inhalation use. Ridgefield, CT: Boehringer Ingelheim Pharmaceuticals, Inc.; 2021.

    Frequently Asked Questions about Stiolto Respimat

    What is Stiolto Respimat used for?

    Stiolto Respimat is a combination inhalation spray used for long-term maintenance in adults with chronic obstructive pulmonary disease (COPD). It helps improve lung function and control COPD symptoms. It contains two types of medications: tiotropium (an anticholinergic) and olodaterol (a long-acting beta2-agonist). Take 2 puffs once a day.

    How to use Stiolto Respimat?

    To use Stiolto Respimat, prepare the inhaler according to the provided instructions, then inhale the medicine by pressing the dose-release button to release a mist and breathing it into your lungs, taking 2 puffs once daily at a consistent time.

    How long does it take for Stiolto Respimat to work?

    Stiolto Respimat starts working within 5 minutes of inhalation and provides 24 hours of benefit.

    Is Stiolto Respimat a steroid?

    No, Stiolto Respimat is steroid-free. It contains an anticholinergic (tiotropium) and a long-acting beta2-agonist (olodaterol).

    Does Stiolto Respimat cause weight gain?

    In clinical studies, Stiolto Respimat wasn’t found to cause weight gain.

    What are the disadvantages of Respimat?

    Some common side effects of Stiolto Respimat include cough, sore throat, and chest tightness. Serious side effects may include chest pain, fast heartbeat, and difficulty breathing.

    Who should not use Stiolto Respimat?

    Stiolto Respimat should not be used by people with asthma. It’s intended for COPD management only. Always carry a rescue inhaler for sudden symptoms.

    What drug interacts with Stiolto Respimat?

    Stiolto Respimat has major interactions, such as with albuterol and certain antidepressants, where benefits should outweigh risks; moderate interactions, like with aspirin and lisinopril, require cautious use; and minor interactions, including with gabapentin and hydroxyzine, are clinically insignificant but should still be noted.

    Can you use Stiolto Respimat twice a day?

    No, Stiolto Respimat is taken once a day (2 puffs) for 24-hour benefit.

    How long does Respimat last?

    Stiolto Respimat provides 24 hours of action after a single daily dose.

    IMPORTANT NOTE: The above information is intended to increase awareness of health information and does not suggest treatment or diagnosis. This information is not a substitute for individual medical attention and should not be construed to indicate that use of the drug is safe, appropriate, or effective for you. See your health care professional for medical advice and treatment.

    Product Code : 13186

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