What is a Generic Drug?
A generic drug is a copy of the brand-name drug with the same dosage, safety, strength, quality, consumption method, performance, and intended use. Before generics become available on the market, the generic company must prove it has the same active ingredients as the brand-name drug and works in the same way and in the same amount of time in the body.
The only differences between generics and their brand-name counterparts is that generics are less expensive and may look slightly different (eg. different shape or color), as trademarks laws prevent a generic from looking exactly like the brand-name drug.
Generics are less expensive because generic manufacturers don't have to invest large sums of money to develop a drug. When the brand-name patent expires, generic companies can manufacture a copy of the brand-name and sell it at a substantial discount.
Stiolto
Also Known as Spiolto
Prescription Required
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Product Details
Description
Stiolto Respimat (tiotropium bromide and olodaterol inhalation spray) is used for long-term maintenance of chronic obstructive pulmonary disease (COPD) in adults.
Stiolto Respimat contains an anticholinergic, tiotropium bromide, and a long-acting beta2-adrenergic agonist, olodaterol. These are medicines that help open up the muscles around your airways, allowing you to breathe better.
Stiolto Respimat should not be used for acute deterioration of COPD.
Stiolto Respimat should not be used to treat asthma.
Fact Table
Formula
C21H26N2O5
License
US FDA
Bioavailability
~30%
Legal status
Rx-Only
Chemical Name
Tiotropium Bromide / Olodaterol
Elimination half-life
7.5 hours
Dosage (Strength)
2.5mcg/2.5mcg (60 puffs/30 doses/inhaler)
Pregnancy
Consult Doctor
Brands
Stiolto Respimat
Protein binding
~60%
PubChem CID
11504295
MedlinePlus
a615019
ChEBI
82700
ATC code
R03AC19
DrugBank
DB09080
KEGG
D10145
Routes of administration
Inhalation
Directions
Be sure to follow your Stiolto Respimat prescription's instructions. Reach out to your doctor or pharmacist if you have any questions or concerns.
Stiolto Respimat is available in an inhalation spray. Each spray provides 2.5 mcg of tiotropium and 2.5 mcg of olodaterol.
The recommended dosage for Stiolto Respimat is to inhale two puffs by mouth once daily. Use at the same time each day.
Ingredients
The active ingredients in Stiolto Respimat are tiotropium bromide, an anticholinergic, and olodaterol, a long-acting beta2-adrenergic agonist.
The inactive ingredients include water for injection, benzalkonium chloride, edetate disodium, and hydrochloric acid.
Contraindications
Do not use Stiolto Respimat without an inhaled corticosteroid if you have asthma.
Do not use Stiolto Respimat if you have an allergy to tiotropium, ipratropium, olodaterol, or any ingredient in Stiolto Respimat.
Cautions
- Before you begin treatment with Stiolto Respimat, be sure to discuss the following with your doctor:
- Your allergies
- Your health problems
- All the medications you take. These include prescription and over-the-counter medications, as well as vitamins and herbal supplements.
- If you are pregnant, think you are pregnant, or have plans to become pregnant.
- If you are breastfeeding or have plans to breastfeed your baby.
- Stiolto Respimat should not be used in patients who have acutely deteriorating COPD, a serious condition that can be fatal. Talk to your doctor about your COPD.
- Stiolto Respimat should not be used as a rescue inhaler.
- Do not use more than the recommended dose of Stiolto Respimat.
- Using Stiolto Respimat with other medications that have long-acting beta2-adrenergic agonists can cause serious and potentially life-threatening cardiovascular problems.
- Stop taking Stiolto Respimat and seek emergency care immediately if you experience swelling, itching, rash, bronchospasm, trouble breathing, or other effects. These could be signs and symptoms of a serious allergic reaction.
- Stiolto Respimat has the potential to cause paradoxical bronchospasm that may be fatal.
- Caution should be used if you have cardiovascular or convulsive problems, thyroid problems, or if you cannot tolerate sympathomimetic drugs.
- Stiolto Respimat can worsen glaucoma. Caution should be used if you have glaucoma.
- Stiolto Respimat can worsen urinary retention. Caution should be used if you have prostatic hyperplasia or bladder-neck obstruction.
- Stiolto Respimat can cause low potassium and high blood glucose levels.
Side Effects
Nasopharyngitis, cough, and back pain are the most common side effects associated with Stiolto Respimat; however, these are not all the side effects that can occur with its use. Contact your doctor immediately if worsening or continuous side effects occur.
Reference:
Stiolto Respimat (tiotropium bromide and olodaterol inhalation spray), for oral inhalation use. Ridgefield, CT: Boehringer Ingelheim Pharmaceuticals, Inc.; 2021.
IMPORTANT NOTE: The above information is intended to increase awareness of health information and does not suggest treatment or diagnosis. This information is not a substitute for individual medical attention and should not be construed to indicate that use of the drug is safe, appropriate, or effective for you. See your health care professional for medical advice and treatment.Product Code : 13186
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