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A generic drug is a copy of the brand-name drug with the same dosage, safety, strength, quality, consumption method, performance, and intended use. Before generics become available on the market, the generic company must prove it has the same active ingredients as the brand-name drug and works in the same way and in the same amount of time in the body.
The only differences between generics and their brand-name counterparts is that generics are less expensive and may look slightly different (eg. different shape or color), as trademarks laws prevent a generic from looking exactly like the brand-name drug.
Generics are less expensive because generic manufacturers don't have to invest large sums of money to develop a drug. When the brand-name patent expires, generic companies can manufacture a copy of the brand-name and sell it at a substantial discount.
Stivarga can be obtained with a valid prescription to treat metastatic colorectal cancer, gastrointestinal stromal tumor, and liver cancer.
Stivarga comes in 40 mg tablets for oral administration.
Take Stivarga exactly as your doctor has prescribed. If any questions or concerns arise, reach out to your doctor or pharmacist.
A typical Stivarga dose is 160 mg by mouth one time a day for the first 21 days of each 28-day cycle. It should be taken after a low-fat meal. Your doctor will tell you how much Stivarga is right for you.
Regorafenib is the active ingredient contained in Stivarga. The inactive ingredients include cellulose microcrystalline,croscarmellose sodium, magnesium stearate, povidone, colloidal silicon dioxide, ferric oxide red, ferric oxide yellow, lecithin (soy), polyethylene glycol 3350, polyvinyl alcohol, talc, and titanium dioxide.
There are no contraindications per the most recent Stivarga Prescribing Information.
Stivarga has an FDA Boxed Warning regarding the occurrence of liver damage that can be severe or fatal. Liver function should be monitored before and during treatment. Stivarga should be stopped or the dose should be reduced if liver damage occurs as observed by elevated liver enzymes or liver cell necrosis and is based on severity and persistence.
Common Stivarga side effects include stomach pain, fatigue, diarrhea, decreased appetite, high blood pressure, infection, difficulty speaking, elevated bilirubin levels, fever, inflamed/sore mouth, weight loss, rash, and nausea; however, other side effects may also occur. Immediately contact your doctor if you have side effects that bother you or won’t go away.
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Stivarga. Whippany, NJ: Bayer HealthCare Pharmaceuticals Inc.; 2020.