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Surolan

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A generic drug is a copy of the brand-name drug with the same dosage, safety, strength, quality, consumption method, performance, and intended use. Before generics become available on the market, the generic company must prove it has the same active ingredients as the brand-name drug and works in the same way and in the same amount of time in the body.

The only differences between generics and their brand-name counterparts is that generics are less expensive and may look slightly different (eg. different shape or color), as trademarks laws prevent a generic from looking exactly like the brand-name drug.

Generics are less expensive because generic manufacturers don't have to invest large sums of money to develop a drug. When the brand-name patent expires, generic companies can manufacture a copy of the brand-name and sell it at a substantial discount.

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  • Product Details

    Description

    Surolan is a topical otic and dermatologic suspension indicated for the treatment of otitis externa and certain dermatologic conditions in dogs, caused by bacterial, fungal, and yeast infections. It contains a combination of miconazole nitrate (an antifungal), polymyxin B sulfate (an antibacterial), and prednisolone acetate (a corticosteroid). This triple-action formulation treats common pathogens such as Malassezia pachydermatis, Staphylococcus pseudintermedius, and Candida albicans, while also reducing inflammation and pruritus.

    Fact Table

    Formula

    Combination: Polymyxin B + Miconazole + Prednisolone

    License

    EMA (veterinary use), FDA (veterinary use)

    Bioavailability

    Primarily local (topical use)

    Legal status

    Veterinary Rx-only

    Chemical Name

    Miconazole nitrate + Polymyxin B sulfate + Prednisolone acetate

    Elimination half-life

    Not systemically relevant (topical use)

    Dosage (Strength)

    5 mg/mL miconazole, 0.5293 mg/mL polymyxin B, 0.5 mg/mL prednisolone

    Pregnancy

    Use with caution (veterinary discretion)

    Brands

    Surolan

    Protein binding

    Not applicable (local topical action)

    PubChem CID

    Miconazole: 4189; Polymyxin B: 5311054; Prednisolone: 5755

    MedlinePlus

    Not applicable (veterinary)

    ChEBI

    Miconazole (ChEBI:6820), Prednisolone (ChEBI:8377)

    ATC code

    QD07CC01 (veterinary combination)

    DrugBank

    Miconazole: DB01110; Polymyxin B: DB00781; Prednisolone: DB00860

    KEGG

    Prednisolone: D00447; Miconazole: D00425

    Routes of administration

    Topical (aural/skin in animals)

    Directions

    Surolan is for topical administration only in dogs. Shake well before use.

    • For otitis externa: Administer 5 drops into the affected ear(s) twice daily for 7 consecutive days, unless otherwise directed by a veterinarian.
    • For skin infections: Apply a thin layer to the affected area twice daily and gently massage in.

    Clean the ear canal or affected skin prior to application if necessary. Wash hands after handling. Avoid contact with the eyes and do not use in animals intended for breeding unless deemed necessary by a veterinarian.

    Ingredients

    Each mL of Surolan contains:

    • Miconazole nitrate – 23 mg (antifungal)
    • Polymyxin B sulfate – 0.5293 mg (antibacterial)
    • Prednisolone acetate – 5 mg (anti-inflammatory corticosteroid)
    • Excipients: Liquid paraffin, polyethylene oleyl ether, and other stabilizers

    Contraindications

    Do not use Surolan in dogs with:

    • Perforated tympanic membrane (ruptured eardrum)
    • Known hypersensitivity to any of the active ingredients
    • Pregnant or lactating animals, unless clearly indicated

    Cautions

    • Use only as directed by a veterinarian; inappropriate use can lead to resistance or adverse effects.
    • Long-term or repeated use may result in overgrowth of non-susceptible organisms, including fungi or resistant bacteria.
    • Use with caution in animals with hepatic impairment due to corticosteroid component.
    • In case of worsening symptoms or lack of improvement, re-evaluate diagnosis and treatment plan.
    • Not for use in cats, unless specifically prescribed by a veterinarian.

    Side Effects

    Reported side effects may include:

    • Mild local irritation or redness
    • Ototoxicity (hearing loss, head tilt) if used with ruptured eardrum
    • Temporary hearing loss (especially in sensitive breeds or elderly dogs)
    • Corticosteroid-related effects (if absorbed systemically over time)

    Discontinue use and consult a veterinarian if adverse reactions occur or symptoms worsen.

    IMPORTANT NOTE: The above information is intended to increase awareness of health information and does not suggest treatment or diagnosis. This information is not a substitute for individual medical attention and should not be construed to indicate that use of the drug is safe, appropriate, or effective for you. See your health care professional for medical advice and treatment.

    Product Code : 10159

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