A generic drug is a copy of the brand-name drug with the same dosage, safety, strength, quality, consumption method, performance, and intended use. Before generics become available on the market, the generic company must prove it has the same active ingredients as the brand-name drug and works in the same way and in the same amount of time in the body.
The only differences between generics and their brand-name counterparts is that generics are less expensive and may look slightly different (eg. different shape or color), as trademarks laws prevent a generic from looking exactly like the brand-name drug.
Generics are less expensive because generic manufacturers don't have to invest large sums of money to develop a drug. When the brand-name patent expires, generic companies can manufacture a copy of the brand-name and sell it at a substantial discount.
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Synjardy XR (empagliflozin and metformin hydrochloride extended-release) is used with diet and exercise to treat adults with type 2 diabetes.
Synjardy XR is available in oral tablets of the following strengths:
Take Synjardy XR as your doctor has prescribed. If you have any questions or concerns, talk to your doctor or pharmacist.
Synjardy XR dosing is individualized based on kidney function and current treatment regimen.
Typically, the dose is to take one tablet by mouth once daily with breakfast. The maximum recommended dose is 25 mg empagliflozin/2,000 mg metformin HCl daily. The tablet should be swallowed whole; do not split, crush, or chew it.
You may need to stop taking Synjardy XR at the time of, or before, receiving iodinated contrast imaging.
Each Synjardy XR tablet contains empagliflozin, a sodium-glucose co-transporter 2 (SGLT2) inhibitor and metformin hydrochloride, a biguanide.
Inactive ingredients include polyethylene oxide, hypromellose, and magnesium stearate. The tablet film coating and ink include hypromellose, titanium dioxide, polydextrose, polyethylene glycol, talc, carnauba wax, purified water, ferrosoferric oxide, propylene glycol, isopropyl alcohol, ferric oxide yellow (5 mg/1,000 mg; 10 mg/1,000 mg; 25 mg/1,000 mg), ferric oxide red (10 mg/1,000 mg), and FD and C blue#2/indigo carmine aluminum lake (12.5 mg/1,000 mg; 25 mg/1,000 mg).
Patients with severe kidney problems, metabolic acidosis, or an allergy to empagliflozin, metformin, or any of the other ingredients should not take Synjardy XR.
Synjardy XR has FDA Boxed Warnings regarding cases of lactic acidosis associated with metformin that led to death, hypothermia, low blood pressure, and resistant, slow heart arrhythmias. Patients who have kidney problems, are using certain medications, are 65 years old or older, have radiological studies with contrast, have surgery or other procedures, have low oxygen levels, consume excessive amounts of alcohol, or have liver problems may be at increased risk.
Common Synjardy XR side effects include urinary tract infection, fungal infection in the genital areas, diarrhea, nausea, vomiting, gas, stomach discomfort, indigestion, headache, and weakness. However, these are not all the side effects that can occur.
Contact your doctor right away if you develop side effects that bother you or won't go away.
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