What is a Generic Drug?
A generic drug is a copy of the brand-name drug with the same dosage, safety, strength, quality, consumption method, performance, and intended use. Before generics become available on the market, the generic company must prove it has the same active ingredients as the brand-name drug and works in the same way and in the same amount of time in the body.
The only differences between generics and their brand-name counterparts is that generics are less expensive and may look slightly different (eg. different shape or color), as trademarks laws prevent a generic from looking exactly like the brand-name drug.
Generics are less expensive because generic manufacturers don't have to invest large sums of money to develop a drug. When the brand-name patent expires, generic companies can manufacture a copy of the brand-name and sell it at a substantial discount.
Tafinlar (Dabrafenib)
Prescription Required
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Product Details
Description
Tafinlar is a prescription medication used to treat advanced melanoma, a type of skin cancer. It is a kinase inhibitor that targets the BRAF protein, which is involved in the growth and spread of cancer cells.
Fact Table
Formula
C23H20F3N5O2S2
License
US DailyMed, EU EMA
Bioavailability
95%
Legal status
Rx-Only
Chemical Name
Dabrafenib
Elimination half-life
8 hours
Dosage (Strength)
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Pregnancy
Consult Doctor
Brands
Tafinlar
Protein binding
99.7%
PubChem CID
44462760
MedlinePlus
a613038
ChEBI
75045
ATC code
L01EC02
DrugBank
DB08912
KEGG
D10064
Routes of administration
By mouth
Directions
The recommended dose is 150 mg taken by mouth twice daily. Tafinlar can be taken with or without food.
Do not take Tafinlar in a way differently than prescribed.
Ingredients
The active ingredient in Tafinlar is dabrafenib.
Interactions
Tell your healthcare team if you are taking any of the following:
- Abemaciclib
- Alfentanil
- Aminolevulinic Acid
- Antihepaciviral Combination Products
- Asunaprevir
- Atogepant
- Avacopan
- Avanafil
- Avapritinib
- Axitinib
- Bedaquiline
- Bosutinib
- Brigatinib
- Capmatinib
- Cariprazine
- Clarithromycin
- Cobimetinib
- CYP2C8 Inhibitors
- CYP3A4 Inhibitors
- Daclatasvir
- Daridorexant
- Dasabuvir
- Deflazacort
- Disopyramide
- Domperidone
- DOXOrubicin
- Dronedarone
- Duvelisib
- Elbasvir and Grazoprevir
- Encorafenib
- Entrectinib
- Erdafitinib
- Fedratinib
- Fexinidazole
- Finerenone
- Flibanserin
- Fusidic Acid
- Ganaxolone
- Glasdegib
- GuanFACINE
- Hormonal Contraceptives
- Ibrexafungerp
- Indinavir
- Infigratinib
- Ivabradine
- Larotrectinib
- Lefamulin
- Lemborexant
- Lenacapavir
- Levoketoconazole
- Lonafarnib
- Lorlatinib
- Lumateperone
- Lurasidone
- Lurbinectedin
- Maraviroc
- Mavacamten
- Methadone
- Mitapivat
- Mobocertinib
- Neratinib
- Nisoldipine
- Olaparib
- Olutasidenib
- Orelabrutinib
- Pacritinib
- Pemigatinib
- Perampanel
- Pimavanserin
- Pimozide
- Praziquantel
- Pretomanid
- QT-prolonging Agents
- QT-prolonging Strong CYP3A4 Inhibitors
- QuiNIDine
- QuiNINE
- Ranolazine
- Rimegepant
- Ripretinib
- Selpercatinib
- Selumetinib
- Sertindole
- Simeprevir
- Sonidegib
- Tazemetostat
- Ubrogepant
- Ulipristal
- Vandetanib
- Velpatasvir
- Venetoclax
- Voclosporin
- Vonoprazan
- Vorapaxar
- Voxelotor
- Voxilaprevir
- Zanubrutinib
Cautions
Tafinlar may cause severe skin reactions, fever, and liver problems. Inform your doctor if you have a history of skin cancer, liver disease, or heart problems before starting Tafinlar.
Tafinlar may also cause new melanomas or non-melanoma skin cancers. Inform your doctor of any changes in your skin, including new moles or growths.
Tafinlar may also cause eye problems, including uveitis and vision loss. Inform your doctor if you experience any changes in your vision.
Side Effects
The most common side effects of Tafinlar may include
- Alopecia
- Arthralgia
- Back pain
- Basal cell carcinoma of the skin
- Bullous rash
- Chills
- Constipation
- Cough
- Dizziness
- Fatigue
- Febrile reaction
- Fever
- Headache
- Hyperglycemia
- Hyperkeratosis
- Hyponatremia
- Hypophosphatemia
- Increased serum alkaline phosphatase
- Interstitial nephritis
- Kaposi sarcoma
- Keratoacanthoma
- Malignant melanoma
- Malignant neoplasm
- Myalgia
- Nasopharyngitis
- Palmar-plantar erythrodysesthesia
- Pancreatitis
- Papilloma
- Skin rash
- Squamous cell carcinoma of skin
- Uveitis
- Xeroderma
References
Tafinlar [package insert]. Research Triangle Park, NC: GlaxoSmithKline; 2014.
IMPORTANT NOTE: The above information is intended to increase awareness of health information and does not suggest treatment or diagnosis. This information is not a substitute for individual medical attention and should not be construed to indicate that use of the drug is safe, appropriate, or effective for you. See your health care professional for medical advice and treatment.Product Code : 13755
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