Description
Talzenna (Talazoparib) is a prescription medication that is used to treat certain breast and prostate cancers that have BRCA1 or BRCA2 gene mutations. It works by blocking the PARP enzyme, which BRCA mutations rely on to repair their DNA. Meanwhile, other cells are less affected. When the PARP enzyme is blocked, BRCA mutations are unable to repair themselves and die.
Directions
Talzenna (Talazoparib) is available as oral capsules in 0.1 mg, 0.25 mg, 0.35 mg, 0.5 mg, 0.75 mg, and 1 mg strengths. The prescribed Talzenna dosage may vary based on factors such as your kidney function and your body’s response to the medication.
Talzenna should be taken exactly as prescribed and swallowed whole with or without food. However, it should not be opened or dissolved. If you vomit or miss a dose of Talzenna, take the next prescribed dose at the scheduled time.
Your dose also varies depending on the condition being treated:
Breast Cancer
For breast cancer, a 1 mg dose of Talzenna is typically taken once daily until the treatment stops being effective or side effects make it intolerable.
Prostate Cancer
Your doctor will typically prescribe 0.5 mg once daily until the treatment stops being effective or side effects make it intolerable. For prostate cancer, Talzenna is taken together with enzalutamide, and additional medical or surgical treatments may be necessary.
Ingredients
The active ingredient in Talzenna is talazoparib tosylate.
Inactive ingredients are silicified microcrystalline cellulose, hypromellose, yellow iron oxide, red iron oxide, titanium dioxide, shellac, black iron oxide, potassium hydroxide, ammonium hydroxide, and propylene glycol.
Contraindications
According to the FDA, there are no contraindications. However, every patient is assessed individually.
Cautions
- Before taking Talzenna, inform your doctor of
- your complete medical history, especially kidney issues, blood disorders, prior cancer treatments, allergies, pregnancy, breastfeeding status, and fertility concerns.
- all the medications you’re taking, including heart or blood pressure drugs, antibiotics, antifungals, chemotherapy, medications that affect blood count, and herbal or vitamin supplements. Some medications can increase Talzenna levels or lower blood counts further, causing serious side effects.
- You may need a lower dose of Talzenna if you have reduced kidney function, since the medication is cleared from the body by the kidneys.
- When you take Talzenna, regular blood tests are required to monitor for low red, white, or platelet counts, as well as rare cases of myelodysplastic syndrome (MDS) or acute myeloid leukemia (AML). If any issues are detected, your doctor will adjust your dose or stop the treatment.
- Avoid pregnancy during treatment as Talzenna can harm an unborn baby.
- Do not breastfeed while taking Talzenna or for at least 1 month after your last dose.
- Do not take Talzenna if you’re allergic to one of its ingredients. Seek immediate medical care if you experience allergy symptoms such as rash, itching, swelling, or trouble breathing.
Side Effects
The most common side effects of Talzenna when taken alone include fatigue, nausea, vomiting, headache, and loss of appetite. More serious side effects requiring medical attention include low red blood cell count (anemia), low white blood cell count (increased infection risk), low platelet count (bleeding and bruising risk), myelodysplastic syndrome (MDS), acute myeloid leukemia (AML) (rare), and fetal harm.
The most common side effects of Talzenna when taken in combination with enzalutamide include tiredness, weakness, nausea, decreased appetite, dizziness, and changes in sense of taste. More serious side effects requiring medical attention include low red blood cell count (anemia), low white blood cell count (increased infection risk), low platelet count (bleeding and bruising risk), bone injuries and fractures, changes in blood minerals, and fertility problems in males.
These are not all the possible Talzenna side effects. If you experience persistent or severe side effects of Talzenna, contact your healthcare provider immediately.
With a valid prescription from your healthcare provider, you can buy Talzenna easily and stress-free, here at Canada Pharmacy!
IMPORTANT NOTE:
The above information is intended to increase awareness of health information and does not suggest treatment or diagnosis. This information is not a substitute for individual medical attention and should not be construed to indicate that use of the drug is safe, appropriate, or effective for you. See your health care professional for medical advice and treatment.
Product Code : 15465
Prescription Required
