What is a Generic Drug?
A generic drug is a copy of the brand-name drug with the same dosage, safety, strength, quality, consumption method, performance, and intended use. Before generics become available on the market, the generic company must prove it has the same active ingredients as the brand-name drug and works in the same way and in the same amount of time in the body.
The only differences between generics and their brand-name counterparts is that generics are less expensive and may look slightly different (eg. different shape or color), as trademarks laws prevent a generic from looking exactly like the brand-name drug.
Generics are less expensive because generic manufacturers don't have to invest large sums of money to develop a drug. When the brand-name patent expires, generic companies can manufacture a copy of the brand-name and sell it at a substantial discount.
Temodar (Temozolomide)
Also Known as Temodal
Prescription Required
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Product Details
Description
Temodar is a prescription chemotherapy medication used in the treatment:
- Newly diagnosed glioblastoma multiforme (GBM) along with radiation
- Refractory anaplastic astrocytoma patients who have failed prior treatment
Temodar works by incorporating cancer cells' DNA and preventing their replication.Fact Table
Formula
C6H6N6O2
License
EU EMA, US FDA
Bioavailability
almost 100%
Legal status
Rx-only
Chemical Name
Temozolomide
Elimination half-life
1.8 hours
Dosage (Strength)
5mg, 20mg, 100mg, 180mg, 250mg
Pregnancy
Not Advised
Brands
Temodar, Temodal, Temcad
Protein binding
10–20%
PubChem CID
5394
MedlinePlus
a601250
ChEBI
72564
ATC code
L01AX03
DrugBank
DB00853
KEGG
D06067
Routes of administration
By mouth, intravenous
Directions
Take Temodar exactly as prescribed by your doctor.
Ingredients
The active ingredient is temozolomide.
Interactions
There are many potential drug-drug interactions, including:
- Abrocitinib
- Baricitinib
- BCG Products
- Cladribine
- Coccidioides immitis Skin Test
- COVID-19 Vaccine
- Deferiprone
- Dengue Tetravalent Vaccine
- Denosumab
- Dipyrone
- Fexinidazole
- Influenza Virus Vaccines
- Leflunomide
- Lenograstim
- Lipegfilgrastim
- Live Vaccines
- Natalizumab
- Palifermin
- Pimecrolimus
- Poliovirus Vaccine
- Polymethylmethacrylate
- Rabies Vaccine
- Ropeginterferon Alfa-2b
- Rubella- or Varicella-Containing Live Vaccines
- Ruxolitinib
- Sipuleucel-T
- Tacrolimus
- Talimogene Laherparepvec
- Tertomotide
- Tofacitinib
- Typhoid Vaccine
- Upadacitinib
- Yellow Fever Vaccine
Cautions
Your oncology team should monitor the levels of your blood cells while taking this drug.
Do not take this drug if you are pregnant or intend to become pregnant.
Tell your doctor if you have a history of liver problems.
Side Effects
The most common adverse reactions include:
- Abdominal pain
- Abnormal gait
- Alopecia
- Amnesia
- Anaphylaxis
- Anemia
- Anorexia
- Anxiety
- Aplastic anemia
- Arthralgia
- Asthenia
- Ataxia
- Back pain
- Blurred vision
- Cholestasis
- Confusion
- Constipation
- Cough
- Decreased hemoglobin
- Decreased neutrophils
- Depression
- Diabetes Insipidus
- Diarrhea
- Diplopia
- Dizziness
- Drowsiness
- Dysgeusia
- Dysphagia
- Dyspnea
- Erythema multiforme
- Erythema of skin
- Fatigue
- Fever
- Headache
- Hematoma
- Hemiparesis
- Hepatitis
- Hepatotoxicity
- Hyperbilirubinemia
- Hypercorticoidism
- Hypersensitivity reaction
- Increased liver enzymes
- Infection
- Injection site reaction
- Insomnia
- Interstitial pneumonitis
- Irritation
- Leukopenia
- Lymphocytopenia
- Mastalgia
- Memory impairment
- Myalgia
- Myelodysplastic syndrome
- Nausea
- Pain
- Pancytopenia
- Paresis
- Paresthesia
- Peripheral edema
- Petechiae
- Pharyngitis
- Pneumonia
- Pneumonitis
- Pruritus
- Pruritus
- Pulmonary alveolitis
- Pulmonary fibrosis
- Secondary acute myelocytic leukemia
- Seizure
- Sinusitis
- Skin rash
- Stevens-Johnson Syndrome
- Stomatitis
- Swelling
- Thrombocytopenia
- Toxic epidermal necrolysis
- Upper respiratory tract infection
- Urinary frequency
- Urinary incontinence
- Urinary tract infection
- Viral infection
- Visual disturbance
- Vomiting
- Warmth
- Weight gain
- Xeroderma
References
Temodar [package insert]. Whitehouse Station, NJ: Merck & Co., Inc.; 2016.
IMPORTANT NOTE: The above information is intended to increase awareness of health information and does not suggest treatment or diagnosis. This information is not a substitute for individual medical attention and should not be construed to indicate that use of the drug is safe, appropriate, or effective for you. See your health care professional for medical advice and treatment.Product Code : 10054
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