What is a Generic Drug?
A generic drug is a copy of the brand-name drug with the same dosage, safety, strength, quality, consumption method, performance, and intended use. Before generics become available on the market, the generic company must prove it has the same active ingredients as the brand-name drug and works in the same way and in the same amount of time in the body.
The only differences between generics and their brand-name counterparts is that generics are less expensive and may look slightly different (eg. different shape or color), as trademarks laws prevent a generic from looking exactly like the brand-name drug.
Generics are less expensive because generic manufacturers don't have to invest large sums of money to develop a drug. When the brand-name patent expires, generic companies can manufacture a copy of the brand-name and sell it at a substantial discount.
Tivicay (Dolutegravir)
Prescription Required
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Product Details
Description
Your doctor may prescribe Tivicay for the treatment of HIV-1 infection. This medication should only be prescribed by healthcare professionals trained in the management of HIV and AIDS.
Tivicay is usually not given on its own and will be given with other drugs that help to suppress HIV infection. These types of drugs are called Antiretroviral Therapy (ART).
Tivicay works by shutting off a protein in HIV viral particles called integrase. Integrase is critical for the replication of HIV after it enters a human cell.
Fact Table
Formula
C20H19F2N3O5
License
US FDA, EU EMA
Bioavailability
n/a
Legal status
Rx-only
Chemical Name
Dolutegravir
Elimination half-life
~14 hours
Dosage (Strength)
50mg
Pregnancy
Consult Doctor
Brands
Tivicay, Tivicay PD
Protein binding
98.9%
PubChem CID
54726191
MedlinePlus
a613043
ChEBI
76010
ATC code
J05AJ03
DrugBank
DB08930
KEGG
D10066
Routes of administration
By mouth
Directions
The usual dose is 50 mg by mouth one to two times daily. The dose may be different depending on your individual circumstances.
Ingredients
Dolutegravir is the active ingredient in this drug.
Interactions
There are many potential drug-drug interactions, including:
- Aluminum hydroxide
- Calcium salts
- Carbamazepine
- Dalfampridine
- Dofetilide
- Efavirenz
- Etravirine
- Fosamprenavir
- Fosphenytoin-Phenytoin
- Iron preparations
- Magnesium salts
- Metformin
- Multivitamins
- Nevirapine
- Oxcarbazepine
- Phenobarbital
- Primidone
- Rifampin
- Selenium
- St John's Wort
- Sucralfate
- Tipranavir
- Zinc salts
Cautions
Tell your doctor if you have a history of skin conditions, liver problems, or have a hypersensitivity to any of the ingredients in this medication.
Tell your doctor if you have a history of hepatitis B or hepatitis C infection.
Ask your doctor and pharmacist for a full list of side effects before starting this drug.
Side Effects
The most common side effects of this drug include:
- Increased serum cholesterol
- Abdominal distress
- Abdominal pain
- Abnormal dreams
- Acute hepatic failure
- Anxiety
- Arthralgia
- Depression
- Diarrhea
- Dizziness
- Fatigue
- Flatulence
- Headache
- Hepatitis
- Hepatotoxicity
- Hyperbilirubinemia
- Hyperglycemia
- Hypersensitivity reaction
- Immune reconstitution syndrome
- Increased creatinine phosphokinase
- Increased HDL cholesterol
- Increased LDL cholesterol
- Increased serum alanine aminotransferase
- Increased serum aspartate aminotransferase
- Increased serum creatinine
- Increased serum lipase
- Increased serum triglycerides
- Insomnia
- Myalgia
- Myositis
- Nausea
- Neutropenia
- Pruritus
- Renal insufficiency
- Skin rash
- Suicidal ideation
- Suicidal tendencies
- Upper abdominal pain
- Vomiting
- Weight gain
References
Tivicay [package insert]. Research Triangle Park, NC: GlaxoSmithKline; 2013.
IMPORTANT NOTE: The above information is intended to increase awareness of health information and does not suggest treatment or diagnosis. This information is not a substitute for individual medical attention and should not be construed to indicate that use of the drug is safe, appropriate, or effective for you. See your health care professional for medical advice and treatment.Product Code : 13237
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