What is a Generic Drug?
A generic drug is a copy of the brand-name drug with the same dosage, safety, strength, quality, consumption method, performance, and intended use. Before generics become available on the market, the generic company must prove it has the same active ingredients as the brand-name drug and works in the same way and in the same amount of time in the body.
The only differences between generics and their brand-name counterparts is that generics are less expensive and may look slightly different (eg. different shape or color), as trademarks laws prevent a generic from looking exactly like the brand-name drug.
Generics are less expensive because generic manufacturers don't have to invest large sums of money to develop a drug. When the brand-name patent expires, generic companies can manufacture a copy of the brand-name and sell it at a substantial discount.
Tivorbex (Indomethacin)
Prescription Required
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Product Details
Description
Tivorbex is an NSAID that your healthcare provider may prescribe for the treatment of short-term pain. It works by reducing pain and inflammation.
Fact Table
Formula
C19H16ClNO4
License
US FDA
Bioavailability
~100% (oral), 80–90% (rectal)
Legal status
Rx-Only
Chemical Name
Indometacin
Elimination half-life
2.6-11.2 hours (adults), 12-28 hours (infants)
Dosage (Strength)
40mg
Pregnancy
Consult Doctor
Brands
Indocid, Indocin, Tivorbex
Protein binding
99%
PubChem CID
3715
MedlinePlus
a681027
ChEBI
49662
ATC code
C01EB03
DrugBank
DB00328
KEGG
D00141
Routes of administration
By mouth
Directions
Take Tivorbex at the lowest dosage and for the shortest period to reduce the risk of serious side effects.
The dosage ranges from 20-40 mg by mouth two to three times daily with food.
Ingredients
The active ingredient in Tivorbex is indomethacin.
Interactions
Tell your pharmacist and doctor if you are taking any of the following drugs:
- Abrocitinib
- Acemetacin
- Aminolevulinic Acid
- Apixaban
- Bemiparin
- Cyclosporine
- Dabigatran Etexilate
- Diflunisal
- Edoxaban
- Enoxaparin
- Heparin
- Ketorolac
- Lithium
- Loop Diuretics
- Macimorelin
- Methotrexate
- Mifamurtide
- Nonsteroidal Anti-Inflammatory Agents
- Phenylbutazone
- Pralatrexate
- Rivaroxaban
- Salicylates
- Selective Serotonin Reuptake Inhibitors
- Sincalide
- Sodium Phosphates
- Tenofovir Products
- Tenoxicam
- Tiludronate
- Triamterene
- Urokinase
- Vitamin K Antagonists
Cautions
Tell your doctor if you have a history of cardiovascular disease, gastrointestinal bleeding, liver problems, high blood pressure, edema, or psychiatric illness before starting Tivorbex.
Ask your doctor and pharmacist for a full list of warnings before starting Tivorbex.
Side Effects
Common adverse reactions to Tivorbex may include:
- Abdominal distress
- Abdominal pain
- Acute respiratory distress
- Alopecia
- Anaphylaxis
- Anemia
- Angioedema
- Anorexia
- Anxiety
- Asthma
- Auditory disturbance
- Bloating
- Blurred vision
- Breast tenderness
- Cardiac arrhythmia
- Cardiac failure
- Vasculitis
- Chest pain
- Confusion
- Constipation
- Decreased appetite
- Depression
- Diaphoresis
- Diarrhea
- Dizziness
- Drowsiness
- Dyspepsia
- Dyspnea
- Ecchymoses
- Edema
- Epigastric pain
- Erythema multiforme
- Erythema nodosum
- Exfoliative dermatitis
- Fatigue
- Fever
- Flatulence
- Fluid retention
- Flushing
- Gastroenteritis
- Gastrointestinal hemorrhage
- Gastrointestinal perforation
- Gastrointestinal ulcer
- Headache
- Heartburn
- Hepatic failure
- Hot flash
- Hyperglycemia
- Hyperhidrosis
- Hyperkalemia
- Hypertension
- Hypotension
- Ileitis
- Immune thrombocytopenia
- Insomnia
- Intestinal obstruction
- Intestinal stenosis
- Jaundice
- Leukopenia
- Maculopathy
- Malaise
- Nausea
- Nervousness
- Palpitations
- Pancreatitis
- Paresthesia
- Peptic ulcer
- Peripheral neuropathy
- Postoperative hemorrhage
- Presyncope
- Pruritus
- Psychosis
- Pulmonary edema
- Rectal hemorrhage
- Renal insufficiency
- Seizure
- Shock
- Skin Rash
- Stevens-Johnson syndrome
- Swelling
- Syncope
- Tachycardia
- Tinnitus
- Toxic epidermal necrolysis
- Urticaria
- Vaginal hemorrhage
- Vertigo
- Vomiting
- Weight gain
References
Tivorbex. Philadelphia, PA: Iroko Pharmaceuticals, LLC; 2014.
IMPORTANT NOTE: The above information is intended to increase awareness of health information and does not suggest treatment or diagnosis. This information is not a substitute for individual medical attention and should not be construed to indicate that use of the drug is safe, appropriate, or effective for you. See your health care professional for medical advice and treatment.Product Code : 13629
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