What is a Generic Drug?

A generic drug is a copy of the brand-name drug with the same dosage, safety, strength, quality, consumption method, performance, and intended use. Before generics become available on the market, the generic company must prove it has the same active ingredients as the brand-name drug and works in the same way and in the same amount of time in the body.

The only differences between generics and their brand-name counterparts is that generics are less expensive and may look slightly different (eg. different shape or color), as trademarks laws prevent a generic from looking exactly like the brand-name drug.

Generics are less expensive because generic manufacturers don't have to invest large sums of money to develop a drug. When the brand-name patent expires, generic companies can manufacture a copy of the brand-name and sell it at a substantial discount.

Tolak (Fluorouracil topical )


Tolak (Fluorouracil topical )

Prescription Required

4% Cream

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  • Product Details


    Tolak is a prescription drug that may be given for actinic keratosis of the face.


    The usual directions are to apply twice daily for up to four weeks.


    The active ingredient in Tolak is fluorouracil.


    The common drug interactions for Tolak are

    • 5-Aminosalicylic Acid Derivatives
    • Abrocitinib
    • Allopurinol
    • Aminolevulinic Acid (Systemic)
    • Aminolevulinic Acid (Topical)
    • Amisulpride (Oral)
    • Antithymocyte Globulin (Equine)
    • Baricitinib
    • BC
    • BCG Products
    • Brincidofovir
    • Brivudine
    • Chloramphenicol (Ophthalmic)
    • Cimetidine
    • Cladribine
    • CloZAPine
    • Coccidioides immitis Skin Test
    • COVID-19 Vaccine (Adenovirus Vector)
    • COVID-19 Vaccine (Inactivated Virus)
    • COVID-19 Vaccine (mRNA)
    • COVID-19 Vaccine (Subunit)
    • COVID-19 Vaccine (Virus-like Particles)
    • Dabrafenib
    • Deferiprone
    • Dengue Tetravalent Vaccine (Live)
    • Denosumab
    • Deucravacitinib
    • Dipyrone
    • Domperidone
    • Fexinidazole
    • Filgotinib
    • Fluorouracil Products
    • Folic Acid
    • Fosphenytoin-Phenytoin
    • Gemcitabine
    • Gimeracil
    • Haloperidol
    • Inebilizumab
    • Influenza Virus Vaccines
    • Interferons (Alfa)
    • Leflunomide
    • Lenograstim
    • Leucovorin Calcium-Levoleucovorin
    • Levoketoconazole
    • Lipegfilgrastim
    • Methoxsalen (Systemic)
    • MetroNIDAZOLE (Systemic)
    • Mumps- Rubella- or Varicella-Containing Live Vaccines
    • Nadofaragene Firadenovec
    • Natalizumab
    • Ocrelizumab
    • Ofatumumab
    • Olaparib
    • Ondansetron
    • Palifermin
    • Pentamidine (Systemic)
    • Pidotimod
    • Pimecrolimus
    • Pimozide
    • Pneumococcal Vaccines
    • Poliovirus Vaccine (Live/Trivalent/Oral)
    • Polymethylmethacrylate
    • Porfimer
    • Promazine
    • QT-prolonging Agents
    • Rabies Vaccine
    • Ritlecitinib
    • Ropeginterferon Alfa-2b
    • Ruxolitinib (Topical)
    • Sertindole
    • Sipuleucel-T
    • Sphingosine 1-Phosphate (S1P) Receptor Modulator
    • Tacrolimus (Topical)
    • Talimogene Laherparepvec
    • Tertomotide
    • Tofacitinib
    • TOLBUTamide
    • Typhoid Vaccine
    • Ublituximab
    • Upadacitinib
    • Vaccines (Inactivated/Non-Replicating)
    • Vaccines (Live)
    • Verteporfin
    • Vitamin K Antagonists (eg, warfarin)
    • Yellow Fever Vaccine


    Ask your doctor or pharmacist for a full list of adverse reactions and cautions.

    Side Effects

    Common adverse reactions can include

    • Agranulocytosis
    • Alopecia
    • Anaphylaxis
    • Angina pectoris
    • Anemia
    • Cardiac arrhythmia
    • Cardiac failure
    • Cerebellar syndrome (acute)
    • Cerebrovascular accident
    • Changes in nails (including nail loss)
    • Confusion
    • Dermatitis
    • Diarrhea
    • Disorientation
    • Dysgeusia (Syed 2016)
    • Epistaxis
    • Euphoria
    • Gastrointestinal hemorrhage
    • Gastrointestinal ulcer
    • Headache
    • Hyperpigmentation (supravenous)
    • Hypersensitivity reaction (generalized)
    • Ischemic heart disease
    • Lacrimal stenosis
    • Lacrimation
    • Leukopenia (nadir: days 9 to 14; recovery by day 30)
    • Local thrombophlebitis
    • Maculopapular rash (pruritic)
    • Mesenteric ischemia (acute)
    • Myocardial infarction
    • Nausea
    • Nystagmus
    • Palmar-plantar erythrodysesthesia
    • Pancytopenia
    • Photophobia
    • Skin fissure
    • Skin photosensitivity
    • Stevens-Johnson syndrome
    • Stomatitis
    • Thrombocytopenia
    • Tissue sloughing (gastrointestinal)
    • Toxic epidermal necrolysis
    • Vasospasm
    • Ventricular ectopy
    • Visual disturbance
    • Vomiting
    • Xeroderma


    1. Tolak [package insert]. Sanford, Florida: Hill Dermaceuticals; 2015.

    IMPORTANT NOTE: The above information is intended to increase awareness of health information and does not suggest treatment or diagnosis. This information is not a substitute for individual medical attention and should not be construed to indicate that use of the drug is safe, appropriate, or effective for you. See your health care professional for medical advice and treatment.

    Product Code : 13780

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