What is a Generic Drug?
A generic drug is a copy of the brand-name drug with the same dosage, safety, strength, quality, consumption method, performance, and intended use. Before generics become available on the market, the generic company must prove it has the same active ingredients as the brand-name drug and works in the same way and in the same amount of time in the body.
The only differences between generics and their brand-name counterparts is that generics are less expensive and may look slightly different (eg. different shape or color), as trademarks laws prevent a generic from looking exactly like the brand-name drug.
Generics are less expensive because generic manufacturers don't have to invest large sums of money to develop a drug. When the brand-name patent expires, generic companies can manufacture a copy of the brand-name and sell it at a substantial discount.
Tolsura (Itraconazole)
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Product Details
Description
Tolsura is an antifungal medication that can treat blastomycosis, histoplasmosis, and aspergillosis infections. It works by breaking down the fungal cell membrane, preventing fungal cells from growing.
Fact Table
Formula
C35H38Cl2N8O4
License
US FDA
Bioavailability
~55%
Legal status
Rx-only
Chemical Name
Itraconazole
Elimination half-life
21 hours
Dosage (Strength)
65mg
Pregnancy
Consult Doctor
Brands
Tolsura
Protein binding
99.8%
PubChem CID
55283
MedlinePlus
a692049
ChEBI
6076
ATC code
J02AC02
DrugBank
DB01167
KEGG
D00350
Routes of administration
By mouth
Directions
Your dosage will depend on the type of fungal infection. Take Tolsura as prescribed by your doctor. The standard dosage is 130-260 mg by mouth daily.
Ingredients
The active ingredient in Tolsura is itraconazole.
Interactions
When starting Tolsura, tell your pharmacist and doctor about all drugs you are taking. It may interact with the following:
- Acalabrutinib
- Alfuzosin
- Aliskiren
- Alprazolam
- Aprepitant
- Asciminib
- Astemizole
- Asunaprevir
- Avanafil
- Avapritinib
- Barnidipine
- Bilastine
- Blonanserin
- Bosutinib
- Budesonide
- Cisapride
- Clobetasone
- Cobimetinib
- Conivaptan
- CYP3A4 Inducers
- Dapoxetine
- Daridorexant
- Disopyramide
- Dofetilide
- Domperidone
- Doxorubicin
- Dronedarone
- Efavirenz
- Elagolix, Estradiol, and Norethindrone
- Eletriptan
- Eplerenone
- Ergot Derivatives
- Estazolam
- Everolimus
- Felodipine
- Finerenone
- Flibanserin
- Fluticasone
- Fosaprepitant
- Fusidic Acid
- Ibrutinib
- Infigratinib
- Irinotecan Products
- Isavuconazonium Sulfate
- Ivabradine
- Ivosidenib
- Lefamulin
- Lemborexant
- Lercanidipine
- Levoketoconazole
- Lomitapide
- Lonafarnib
- Lovastatin
- Lumateperone
- Lurasidone
- Lurbinectedin
- Macitentan
- Methadone
- Midazolam
- Mitapivat
- Mizolastine
- Mobocertinib
- Naloxegol
- Neratinib
- Nevirapine
- Nimodipine
- Nisoldipine
- Pacritinib
- Pazopanib
- Pimozide
- Quinidine
- Radotinib
- Ranolazine
- Red Yeast Rice
- Regorafenib
- Rifabutin
- Rimegepant
- Rivaroxaban
- Rupatadine
- Ruxolitinib
- Saccharomyces boulardii
- Salmeterol
- Silodosin
- Simeprevir
- Simvastatin
- Sirolimus
- Sonidegib
- Suvorexant
- Tamsulosin
- Tazemetostat
- Telithromycin
- Tepotinib
- Terfenadine
- Ticagrelor
- Tolvaptan
- Topotecan
- Trabectedin
- Triazolam
- Ubrogepant
- Udenafil
- Vincristine
- Vinflunine
- Voclosporin
- Vorapaxar
Cautions
Your doctor should monitor your liver function while you are taking this drug.
Tell your healthcare provider if you have a history of heart problems, nerve problems, or hearing loss.
Ask your healthcare team for a complete list of warnings and precautions.
Side Effects
Common adverse reactions to this drug may include:
- Abdominal pain
- Abnormal dreams
- Abnormal hepatic function tests
- Anxiety
- Aphthous stomatitis
- Bursitis
- Chest pain
- Constipation
- Cough
- Cystitis
- Depression
- Diaphoresis
- Diarrhea
- Dizziness
- Dyspepsia
- Dyspnea
- Edema
- Fever
- Flatulence
- Gastritis
- Gastroenteritis
- Gastrointestinal disease
- Fatigue
- Gingivitis
- Headache
- Herpes zoster
- Hypertension
- Hypertriglyceridemia
- Hypokalemia
- Increased appetite
- Increased liver enzymes
- Malaise
- Myalgia
- Nausea
- Pain
- Pharyngitis
- Pneumonia
- Pruritus
- Rhinitis
- Sinusitis
- Skin rash
- Tremor
- Upper respiratory tract infection
- Urinary tract infection
- Vomiting
References
Tolsura. Greenville, NC: Mayne Pharma; 2018.
IMPORTANT NOTE: The above information is intended to increase awareness of health information and does not suggest treatment or diagnosis. This information is not a substitute for individual medical attention and should not be construed to indicate that use of the drug is safe, appropriate, or effective for you. See your health care professional for medical advice and treatment.Product Code : 13630
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