Toujeo (Insulin Glargine)

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  • Product Details

    Description

    TOUJEO (insulin glargine) is prescribed to treat high blood sugar (hyperglycemia) in people with diabetes mellitus.

    TOUJEO insulin is a long-acting insulin that is administered once daily, and its effects work for about 24 hours in most people. 

    Compared to other long-acting insulin products, TOUJEO has a higher concentration of 300 units per milliliter. The higher concentration means that people who inject large amounts of insulin can inject the same amount of medication in a lower volume.

    TOUJEO SOLOSTAR pens can hold up to 450 units of insulin (1.5 milliliters.)

    Fact Table

    Formula

    C267H404N72O78S6

    License

    US FDA, EMA

    Bioavailability

    ~60%

    Legal status

    Prescription only (Rx)

    Chemical Name

    Insulin Glargine

    Elimination half-life

    ~19 hours (prolonged due to U-300 formulation)

    Dosage (Strength)

    300 units/mL (U-300)

    Pregnancy

    Category C – Risk cannot be ruled out

    Brands

    Toujeo SoloStar, Toujeo Max SoloStar

    Protein binding

    Low

    PubChem CID

    16131238

    MedlinePlus

    a614033

    ChEBI

    81971

    ATC code

    A10AE04

    DrugBank

    DB00047

    KEGG

    D04559

    Routes of administration

    Subcutaneous injection

    Directions

    Administer TOUJEO subcutaneously once-daily at the same time each day. Do not change the injection time without speaking to your doctor first.

    Rotate injections sites between the abdomen, thighs, and back of the arm to help avoid lipodystrophy.

    Monitor blood sugar closely when making any changes to an insulin regimen.

    Ingredients

    The active ingredient in TOUJEO is insulin glargine.

    Interactions

    The following medications can change blood sugar, requiring that the dose of TOUJEO be adjusted:

    • Alcohol
    • Atypical Antipsychotics
    • Beta-blockers
    • Clonidine
    • Corticosteroids
    • Disopyramide
    • Diuretics
    • Estrogens/Progesterones
    • Fibrates
    • Fluoxetine
    • Isoniazid
    • Lithium
    • Monoamine Oxidase Inhibitors (MAOIs)
    • Niacin
    • Oral antidiabetic agents
    • Pentoxifylline
    • Phenothiazine derivatives
    • Pramlintide
    • Propoxyphene
    • Protease inhibitors
    • Salicylates
    • Somatostatin Analogues
    • Somatropin
    • Sulfonamide Antibiotics
    • Sympathomimetic agents
    • Thyroid replacement medication

    Tell your doctor if you are taking any of the above.

    Cautions

    Hypoglycemia is a common side effect of TOUJEO and other insulin products. The symptoms of hypoglycemia can include:

    • Anxiety
    • Confusion
    • Dizziness
    • Fatigue
    • Hunger
    • Irritability
    • Pale skin
    • Sweating
    • Tremor

    Read the label on the TOUJEO pen carefully before each injection. This helps to prevent medication errors.

    While taking insulin, your doctor should monitor potassium levels, kidney function, and liver function.

    Tell your doctor if you have a history of cardiovascular disease.

    Side Effects

    • Allergic reactions
    • Edema
    • Hypoglycemia
    • Injection site reactions
    • Lipodystrophy
    • Pruritis
    • Rash
    • Weight gain

    References

    TOUJEO [package insert] Bridgewater, NJ: Sanofi-Aventis; 2015.




    Frequently Asked Questions about Toujeo (Insulin Glargine U-300)


    What is Toujeo (Insulin Glargine U-300)?

    Toujeo is a long-acting insulin (insulin glargine) used to manage blood sugar in adults and children 6 years and older with type 1 or type 2 diabetes. It's a concentrated version of Lantus, with 300 units/mL.


    How is Toujeo different from Lantus?

    Toujeo is three times more concentrated than Lantus (U-300 vs. U-100). It also has a smoother, longer action (up to 36 hours) and a lower risk of nighttime hypoglycemia.


    When should I take Toujeo?

    Toujeo is taken once daily, at the same time each day, regardless of meals. Try to keep the timing consistent.


    How long does Toujeo last?

    Toujeo starts working in about 6 hours, and its glucose-lowering effect can last up to 36 hours, with a steady, peakless action.


    Can Toujeo be used in children?

    Yes. Toujeo is approved for children 6 years and older with type 1 or type 2 diabetes.


    What devices is Toujeo available in?

    Toujeo comes in:

    SoloStar pen (max dose: 80 units per injection)
    Max SoloStar pen (max dose: 160 units per injection)
    No vials are available.


    Can Toujeo be used with other diabetes medications?

    Yes. Toujeo is often used with mealtime insulin in type 1 diabetes, and with oral or injectable medications in type 2 diabetes.


    What are common side effects of Toujeo?

    Common side effects include:

    Low blood sugar (hypoglycemia)
    Injection site reactions
    Weight gain

    Rare: Allergic reactions, lipodystrophy


    How should I store Toujeo pens?

    Unopened: Store in the refrigerator

    In use: Store at room temperature (below 86°F / 30°C) for up to 56 days
    Do not freeze.


    Can Toujeo be mixed with other insulins?

    No. Toujeo must be used alone and should never be mixed with any other insulin in the same syringe.

    IMPORTANT NOTE: The above information is intended to increase awareness of health information and does not suggest treatment or diagnosis. This information is not a substitute for individual medical attention and should not be construed to indicate that use of the drug is safe, appropriate, or effective for you. See your health care professional for medical advice and treatment.

    Product Code : 13367

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