What is a Generic Drug?
A generic drug is a copy of the brand-name drug with the same dosage, safety, strength, quality, consumption method, performance, and intended use. Before generics become available on the market, the generic company must prove it has the same active ingredients as the brand-name drug and works in the same way and in the same amount of time in the body.
The only differences between generics and their brand-name counterparts is that generics are less expensive and may look slightly different (eg. different shape or color), as trademarks laws prevent a generic from looking exactly like the brand-name drug.
Generics are less expensive because generic manufacturers don't have to invest large sums of money to develop a drug. When the brand-name patent expires, generic companies can manufacture a copy of the brand-name and sell it at a substantial discount.
Trelegy Ellipta (Fluticasone Furoate / Umeclidinium / Vilanterol Trifenatate)
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Product Details
Description
TRELEGY ELLIPTA is a prescription medication used to treat chronic obstructive pulmonary disease (COPD). TRELEGY ELLIPTA contains a combination of three different medications that are used as maintenance therapy to improve breathing in people with COPD.
Fact Table
Formula
C80H96Cl2F3N2O13S+
License
EU EMA, US FDA
Bioavailability
15.2%
Legal status
RX Only
Chemical Name
Fluticasone Furoate / Umeclidinium / Vilanterol Trifenatate
Elimination half-life
15.1 hours
Dosage (Strength)
92/55/22mcg (100/62.5/25mcg) (30 doses/inhaler), 200/62.5/25mcg (30 doses/inhaler)
Pregnancy
Consult a doctor
Brands
Trelegy Ellipta
Protein binding
Greater than 99.6%
PubChem CID
122403924
MedlinePlus
a618017
ChEBI
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ATC code
R03AL08
DrugBank
DB08906, DB09076, DB09082
KEGG
D11035
Routes of administration
Topical
Directions
Inhale one inhalation of TRELEGY ELLIPTA once daily.
After taking a TRELEGY ELLIPTA dosage, always rinse the mouth with water without swallowing after use, as the ingredient fluticasone can increase the risk of oropharyngeal candidiasis (thrush).
Ingredients
Fluticasone Fumarate
Fluticasone fumarate is an inhaled corticosteroid (ICS) which works by reducing inflammation in the cells of the lungs. Inflammation narrows the passages of the lungs and makes it difficult to breathe. In patients with COPD, cells of the immune system are overactive and ICSs help to reduce inflammation and make breathing easier.
Umeclidinium
Umeclidinium is a long-acting muscarinic antagonist (LAMA) or anticholinergic medication. Anticholinergics work by binding to smooth muscle cells of the lungs and relaxing the airways.
Vilanterol
Vilanterol is a long-acting beta-agonist (LABA). Vilanterol works by attaching to beta-receptors, which are located on the surface of smooth muscle cells in the lungs. By attaching to beta-receptors, vilanterol increases levels of the signaling molecule cyclic AMP (cAMP) and causes the muscles of the lungs to relax.
Cautions
Do not use TRELEGY ELLIPTA for acute bronchospasm or the treatment of asthma. If you are having trouble breathing, a rescue inhaler, like albuterol, should be used for immediate relief. TRELEGY ELLIPTA is a chronic medication and takes several days of regular use to begin working.
TRELEGY ELLIPTA may increase the risk of pneumonia in patients with COPD.
Use with caution if you have a chronic infection, fungal, viral, bacterial, tuberculosis, ocular herpes, or other chronic infections.
Tell your doctor if you have a history of heart problems.
Tell your doctor if you have a history of or current narrow-angle glaucoma as TRELEGY ELLIPTA may worsen the condition.
TRELEGY ELLIPTA may worsen urinary retention in patients who have bladder-neck obstruction or benign prostatic hyperplasia.
TRELEGY ELLIPTA has the potential to interact with many different medical conditions. Speak with your doctor or pharmacist for a full list of precautions.
Side Effects
The most common adverse effect of TRELEGY ELLIPTA may include:
- Back pain
- Cough
- Diarrhea
- Dysgeusia
- Gastroenteritis
- Headache
- Oropharyngeal Pain
References
- Trelegy Ellipta [package insert]. Research Triangle Park, NC: GlaxoSmithKline; 2017.
Frequently Asked Questions about Trelegy Ellipta
What is Trelegy Ellipta prescribed for?
Trelegy Ellipta treats COPD (chronic obstructive pulmonary disease), including bronchitis and emphysema. It is also used for asthma in adults as a maintenance treatment.
Is Trelegy Ellipta inhaler a steroid?
Yes, Trelegy Ellipta contains fluticasone, which is an inhaled corticosteroid (ICS). It helps reduce inflammation in the airways.
Is Trelegy a high-risk medication?
Trelegy Ellipta is not considered a high-risk medication. However, like any medication, it has potential side effects. Consult your doctor for personalized advice.
What stage of COPD is Trelegy Ellipta used for?
Trelegy Ellipta is used as a maintenance treatment in adult patients with moderate to severe COPD who are not adequately treated by other medications.
What are the most common side effects of Trelegy?
Common side effects are sore throat, cold, sinus inflammation, back pain, and cough.
How long can a person use Trelegy?
Trelegy Ellipta is used daily for long-term maintenance. Consult your doctor for individualized guidance.
Does Trelegy make you gain weight?
Weight gain is not a common side effect of Trelegy Ellipta.
How long does it take for Trelegy to start working?
Improvement in symptoms may occur within a few days to a couple of weeks of starting Trelegy.
Why is Trelegy so expensive?
The cost of medications can vary due to factors such as research, development, and production. Consult your pharmacist or insurance provider for cost details.
Is Trelegy safe for long-term use?
Trelegy Ellipta is generally safe for long-term use when prescribed by a healthcare professional.
What drugs interact with Trelegy?
Consult your doctor or pharmacist for specific drug interactions related to your health and medications.
Can Trelegy cause heart problems?
Serious heart problems are rare but possible. Monitor for any unusual symptoms and seek medical attention if needed.
Should I take Trelegy in the morning or at night?
Trelegy Ellipta is usually taken once daily. Follow your doctor’s instructions regarding the best time to take it.
IMPORTANT NOTE: The above information is intended to increase awareness of health information and does not suggest treatment or diagnosis. This information is not a substitute for individual medical attention and should not be construed to indicate that use of the drug is safe, appropriate, or effective for you. See your health care professional for medical advice and treatment.Product Code : 13210
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