Tresiba (Insulin Degludec)

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  • Product Details

    Description

    TRESIBA (Insulin degludec) is a medication prescribed for people with diabetes mellitus. TRESIBA is an insulin product, which means it is an analog of regular human insulin. 

    In healthy people, insulin helps to regulate blood sugar to normal levels. Blood sugar that is too high or low can be harmful to the body. TRESIBA is a long-acting insulin that provides around-the-clock glycemic control.

    Fact Table

    Formula

    C274H411N65O81S6

    License

    US FDA, EMA

    Bioavailability

    ~60%

    Legal status

    Prescription only (Rx)

    Chemical Name

    Insulin Degludec

    Elimination half-life

    25 hours (mean), >42 hours duration of action

    Dosage (Strength)

    100 units/mL (U-100), 200 units/mL (U-200)

    Pregnancy

    Category C – Risk cannot be ruled out

    Brands

    Tresiba

    Protein binding

    >99% (to albumin)

    PubChem CID

    16133794

    MedlinePlus

    a614048

    ChEBI

    83837

    ATC code

    A10AE06

    DrugBank

    DB06607

    KEGG

    D09917

    Routes of administration

    Subcutaneous injection

    Directions

    TRESIBA (Insulin degludec) is a medication prescribed for people with diabetes mellitus. TRESIBA is an insulin product, which means it is an analog of regular human insulin. 

    In healthy people, insulin helps to regulate blood sugar to normal levels. Blood sugar that is too high or low can be harmful to the body. TRESIBA is a long-acting insulin that provides around-the-clock glycemic control.

    Ingredients

    The active ingredient in TRESIBA is insulin degludec.

    Interactions

    Some medications can change the blood sugar in people with diabetes. Speak with your doctor or pharmacist if you are taking any of the following:

    • Alcohol
    • Atypical Antipsychotics
    • Corticosteroids
    • Disopyramide
    • Diuretics
    • Estrogens/Progesterones
    • Fibrates
    • Fluoxetine
    • Isoniazid
    • Lithium
    • Monoamine Oxidase Inhibitors (MAOIs)
    • Niacin
    • Oral antidiabetic agents
    • Pentoxifylline
    • Phenothiazine derivatives
    • Pramlintide
    • Propoxyphene
    • Protease inhibitors
    • Salicylates
    • Somatostatin Analogues
    • Somatropin
    • Sulfonamide Antibiotics
    • Sympathomimetic agents
    • Thyroid replacement medication

    The most common side effect of insulin therapy is low blood sugar (hypoglycemia). The following medications can mask the symptoms and make hypoglycemia harder to detect:

    • Beta-blockers
    • Clonidine
    • Guanethidine
    • Reserpine

    Cautions

    TRESIBA pens should never be shared between multiple patients.

    The doctor should monitor potassium levels while using insulin therapy. They may also monitor kidney and liver function.

    Tell your doctor if you have a history of cardiovascular disease.

    Side Effects

    The most common side effects of TRESIBA can include:

    • Allergic reactions
    • Edema
    • Hypoglycemia
    • Injection site reactions
    • Lipodystrophy
    • Pruritis
    • Rash
    • Weight gain

    References

    1. Tresiba [package insert] Plainsboro, NJ: Novo Nordisk; 2015.



    Frequently Asked Questions about Tresiba (Insulin Degludec)


    What is Tresiba (Insulin Degludec)?

    Tresiba is an ultra-long-acting basal insulin used to manage blood sugar levels in people with type 1 or type 2 diabetes. It provides steady insulin for over 42 hours and is usually taken once daily.


    How is Tresiba different from other long-acting insulins like Lantus?

    Tresiba lasts longer (over 42 hours) and has less daily variability than Lantus. This allows for more flexible dosing time and potentially fewer hypoglycemic episodes.


    When should I take Tresiba?

    Tresiba is taken once daily at the same time, but its long duration allows for some flexibility (within 8–40 hours) between doses if needed. Consistency is still recommended for stability.


    What is the onset and duration of Tresiba?

    Tresiba starts working within 1 hour, with a flat, steady action lasting at least 42 hours with no pronounced peak.


    Can Tresiba be used in children?

    Yes. Tresiba is approved for children as young as 1 year old with type 1 or type 2 diabetes.


    Is Tresiba used alone or with other insulins?

    In type 1 diabetes: Tresiba is used with a mealtime insulin (like Novolog).

    In type 2 diabetes: It can be used alone or with other non-insulin or insulin medications.


    What are common side effects of Tresiba?

    Common side effects include:

    Low blood sugar (hypoglycemia)
    Injection site reactions
    Weight gain

    Rare: Allergic reactions, lipodystrophy


    Can I skip a Tresiba dose or take it late?

    You should not skip doses, but if you're late, Tresiba allows flexibility. You can inject as long as there's at least 8 hours between doses, then resume your usual schedule the next day.


    Is Tresiba available in multiple strengths?

    Yes. Tresiba comes in:

    U-100 (100 units/mL)
    U-200 (200 units/mL)
    Both are equally effective; U-200 allows for smaller injection volume in higher-dose users.


    How should I store Tresiba?

    Unopened: Store in the refrigerator (36°F–46°F / 2°C–8°C)

    In use: Keep at room temp (below 86°F / 30°C) for up to 8 weeks (56 days) — longer than most insulins
    Do not freeze or expose to heat.

    IMPORTANT NOTE: The above information is intended to increase awareness of health information and does not suggest treatment or diagnosis. This information is not a substitute for individual medical attention and should not be construed to indicate that use of the drug is safe, appropriate, or effective for you. See your health care professional for medical advice and treatment.

    Product Code : 13370

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