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Tresiba (Insulin Degludec)
What is a Generic Drug?
A generic drug is a copy of the brand-name drug with the same dosage, safety, strength, quality, consumption method, performance, and intended use. Before generics become available on the market, the generic company must prove it has the same active ingredients as the brand-name drug and works in the same way and in the same amount of time in the body.
The only differences between generics and their brand-name counterparts is that generics are less expensive and may look slightly different (eg. different shape or color), as trademarks laws prevent a generic from looking exactly like the brand-name drug.
Generics are less expensive because generic manufacturers don't have to invest large sums of money to develop a drug. When the brand-name patent expires, generic companies can manufacture a copy of the brand-name and sell it at a substantial discount.
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TRESIBA (Insulin degludec) is a medication prescribed for people with diabetes mellitus. TRESIBA is an insulin product, which means it is an analog of regular human insulin.
In healthy people, insulin helps to regulate blood sugar to normal levels. Blood sugar that is too high or low can be harmful to the body. TRESIBA is a long-acting insulin that provides around-the-clock glycemic control.
Fact Table
Formula
C274H411N65O81S6
License
US FDA, EMA
Bioavailability
~60%
Legal status
Prescription only (Rx)
Chemical Name
Insulin Degludec
Elimination half-life
25 hours (mean), >42 hours duration of action
Dosage (Strength)
100 units/mL (U-100), 200 units/mL (U-200)
Pregnancy
Category C – Risk cannot be ruled out
Brands
Tresiba
Protein binding
>99% (to albumin)
PubChem CID
16133794
MedlinePlus
a614048
ChEBI
83837
ATC code
A10AE06
DrugBank
DB06607
KEGG
D09917
Routes of administration
Subcutaneous injection
Directions
TRESIBA (Insulin degludec) is a medication prescribed for people with diabetes mellitus. TRESIBA is an insulin product, which means it is an analog of regular human insulin.
In healthy people, insulin helps to regulate blood sugar to normal levels. Blood sugar that is too high or low can be harmful to the body. TRESIBA is a long-acting insulin that provides around-the-clock glycemic control.
Ingredients
The active ingredient in TRESIBA is insulin degludec.
Interactions
Some medications can change the blood sugar in people with diabetes. Speak with your doctor or pharmacist if you are taking any of the following:
Alcohol
Atypical Antipsychotics
Corticosteroids
Disopyramide
Diuretics
Estrogens/Progesterones
Fibrates
Fluoxetine
Isoniazid
Lithium
Monoamine Oxidase Inhibitors (MAOIs)
Niacin
Oral antidiabetic agents
Pentoxifylline
Phenothiazine derivatives
Pramlintide
Propoxyphene
Protease inhibitors
Salicylates
Somatostatin Analogues
Somatropin
Sulfonamide Antibiotics
Sympathomimetic agents
Thyroid replacement medication
The most common side effect of insulin therapy is low blood sugar (hypoglycemia). The following medications can mask the symptoms and make hypoglycemia harder to detect:
Beta-blockers
Clonidine
Guanethidine
Reserpine
Cautions
TRESIBA pens should never be shared between multiple patients.
The doctor should monitor potassium levels while using insulin therapy. They may also monitor kidney and liver function.
Tell your doctor if you have a history of cardiovascular disease.
Side Effects
The most common side effects of TRESIBA can include:
Frequently Asked Questions about Tresiba (Insulin Degludec)
What is Tresiba (Insulin Degludec)?
Tresiba is an ultra-long-acting basal insulin used to manage blood sugar levels in people with type 1 or type 2 diabetes. It provides steady insulin for over 42 hours and is usually taken once daily.
How is Tresiba different from other long-acting insulins like Lantus?
Tresiba lasts longer (over 42 hours) and has less daily variability than Lantus. This allows for more flexible dosing time and potentially fewer hypoglycemic episodes.
When should I take Tresiba?
Tresiba is taken once daily at the same time, but its long duration allows for some flexibility (within 8–40 hours) between doses if needed. Consistency is still recommended for stability.
What is the onset and duration of Tresiba?
Tresiba starts working within 1 hour, with a flat, steady action lasting at least 42 hours with no pronounced peak.
Can Tresiba be used in children?
Yes. Tresiba is approved for children as young as 1 year old with type 1 or type 2 diabetes.
Is Tresiba used alone or with other insulins?
In type 1 diabetes: Tresiba is used with a mealtime insulin (like Novolog).
In type 2 diabetes: It can be used alone or with other non-insulin or insulin medications.
What are common side effects of Tresiba?
Common side effects include:
Low blood sugar (hypoglycemia) Injection site reactions Weight gain
Rare: Allergic reactions, lipodystrophy
Can I skip a Tresiba dose or take it late?
You should not skip doses, but if you're late, Tresiba allows flexibility. You can inject as long as there's at least 8 hours between doses, then resume your usual schedule the next day.
Is Tresiba available in multiple strengths?
Yes. Tresiba comes in:
U-100 (100 units/mL) U-200 (200 units/mL) Both are equally effective; U-200 allows for smaller injection volume in higher-dose users.
How should I store Tresiba?
Unopened: Store in the refrigerator (36°F–46°F / 2°C–8°C)
In use: Keep at room temp (below 86°F / 30°C) for up to 8 weeks (56 days) — longer than most insulins Do not freeze or expose to heat.
IMPORTANT NOTE:
The above information is intended to increase awareness of health information and does not suggest treatment or diagnosis. This information is not a substitute for individual medical attention and should not be construed to indicate that use of the drug is safe, appropriate, or effective for you. See your health care professional for medical advice and treatment.
Prescription Required