What is a Generic Drug?

A generic drug is a copy of the brand-name drug with the same dosage, safety, strength, quality, consumption method, performance, and intended use. Before generics become available on the market, the generic company must prove it has the same active ingredients as the brand-name drug and works in the same way and in the same amount of time in the body.

The only differences between generics and their brand-name counterparts is that generics are less expensive and may look slightly different (eg. different shape or color), as trademarks laws prevent a generic from looking exactly like the brand-name drug.

Generics are less expensive because generic manufacturers don't have to invest large sums of money to develop a drug. When the brand-name patent expires, generic companies can manufacture a copy of the brand-name and sell it at a substantial discount.

Treximet (Naproxen/Sumatriptan)


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Generic Equivalent - Treximet (Naproxen/Sumatriptan)

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  • Product Details


    Your doctor may prescribe Treximet to treat migraine headaches with or without aura. It contains two active ingredients: naproxen, a nonsteroidal anti-inflammatory drug (NSAID), and sumatriptan, a selective serotonin receptor agonist.

    Naproxen helps relieve pain and reduce inflammation, while sumatriptan constricts blood vessels in the brain and blocks the release of certain substances that cause migraine symptoms.

    Fact Table




    US FDA, EU EMA, US DailyMed


    15%(Sumatriptan), 95%(Naproxen)

    Legal status


    Chemical Name


    Elimination half-life

    2.5 hours(Sumatriptan), 12–17 hours (Naproxen),

    Dosage (Strength)

    85mg/500mg (Generic)


    Not Recommended



    Protein binding

    14–21%(Sumatriptan), 99%(Naproxen)

    PubChem CID






    ATC code






    Routes of administration

    By mouth


    The recommended dose is one tablet by mouth with water at the onset of a migraine headache. If the headache returns, a second tablet may be taken at least two hours after the first dose.

    The maximum daily dose is two tablets in 24 hours. Do not exceed the recommended dosage or take this medication more often than prescribed.


    The active ingredients are naproxen and sumatriptan.


    Common drug-drug interactions may include

    • Abrocitinib
    • Acemetacin
    • Aminolevulinic Acid
    • Antacids
    • Apixaban
    • Bemiparin
    • Bromocriptine
    • Caplacizumab
    • CycloSPORINE
    • Dabigatran Etexilate
    • Diflunisal
    • Edoxaban
    • Enoxaparin
    • Ergot Derivatives
    • Heparin
    • Ketorolac
    • Lithium
    • Loop Diuretics
    • Macimorelin
    • Methotrexate
    • Mifamurtide
    • Monoamine Oxidase Inhibitors
    • Nonsteroidal Anti-Inflammatory Agents
    • Phenylbutazone
    • PRALAtrexate
    • Rivaroxaban
    • Salicylates
    • Selective Serotonin Reuptake Inhibitors
    • Serotonin 5-HT1D Receptor Agonists
    • Sincalide
    • Sucralfate
    • Tenofovir Products
    • Tenoxicam
    • Urokinase
    • Vitamin K Antagonists


    Tell your doctor if you have a history of severe liver or kidney disease, uncontrolled high blood pressure, or a history of heart disease or stroke.

    It should not be used within 24 hours of taking another medication containing ergotamine or a triptan.

    Tell your doctor if you have a history of seizures, stomach ulcers, or heart problems.

    Side Effects

    The most common side effects may include

    • Acute myocardial infarction
    • Cerebrovascular accident
    • Chest discomfort
    • Chest pain
    • Coronary thrombosis
    • Dizziness
    • Drowsiness
    • Dyspepsia
    • Gastrointestinal hemorrhage
    • Gastrointestinal perforation
    • Gastrointestinal ulcer
    • Hot flash
    • Hypertonia
    • Jaw pain
    • Jaw pressure
    • Jaw tightness
    • Nausea
    • Neck pain
    • Neck pressure
    • Neck tightness
    • Pharyngeal edema
    • Sore throat
    • Xerostomia


    Treximet [package insert]. Research Triangle Park, NC: GlaxoSmithKline; 2011.

    IMPORTANT NOTE: The above information is intended to increase awareness of health information and does not suggest treatment or diagnosis. This information is not a substitute for individual medical attention and should not be construed to indicate that use of the drug is safe, appropriate, or effective for you. See your health care professional for medical advice and treatment.

    Product Code : 13752

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