What is a Generic Drug?
A generic drug is a copy of the brand-name drug with the same dosage, safety, strength, quality, consumption method, performance, and intended use. Before generics become available on the market, the generic company must prove it has the same active ingredients as the brand-name drug and works in the same way and in the same amount of time in the body.
The only differences between generics and their brand-name counterparts is that generics are less expensive and may look slightly different (eg. different shape or color), as trademarks laws prevent a generic from looking exactly like the brand-name drug.
Generics are less expensive because generic manufacturers don't have to invest large sums of money to develop a drug. When the brand-name patent expires, generic companies can manufacture a copy of the brand-name and sell it at a substantial discount.
Tribenzor (Amlodipine / Olmesartan / HCT)
Also Known as Sevikar HCT
Prescription Required
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Product Details
Description
Tribenzor is made of three medications:
- Olmesartan medoxomil - angiotensin II receptor blocker (ARB)
- Amlodipine - dihydropyridine calcium channel blocker (CCB)
- Hydrochlorothiazide - thiazide diuretic
Tribenzor is used to treat high blood pressure.
Fact Table
Formula
C56H63Cl2N11O15S2
License
US DailyMed
Bioavailability
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Legal status
Rx-Only
Chemical Name
Amlodipine / Olmesartan / HCT
Elimination half-life
5.6 and 14.8 hours
Dosage (Strength)
5-20-12.5mg, 5-40-12.5mg, 5-40-25mg, 10-40-12.5mg, 10-40-25mg
Pregnancy
Consult Doctor
Brands
Tribenzor
Protein binding
99%
PubChem CID
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MedlinePlus
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ChEBI
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ATC code
C09DX03
DrugBank
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KEGG
D10288
Routes of administration
By Mouth
Directions
Tribenzor dosage form: tablets
Tribenzor (olmesartan medoxomil/amlodipine/hydrochlorothiazide) strengths:
20 mg/5 mg/12.5 mg, 40 mg/5 mg/12.5 mg, 40 mg/5 mg/25 mg, 40 mg/10 mg/12.5 mg, 40 mg/10 mg/25 mg
Once you are prescribed and buy Tribenzor, Tribenzor is taken by mouth once daily.
Ingredients
The active ingredients in Tribenzor are Olmesartan medoxomil, Amlodipine, and Hydrochlorothiazide.
Contraindications
Do not take Tribenzor if you have abnormally less urine or if you are unable to urinate.
Do not take Tribenzor if you are allergic to any of the ingredients contained in Tribenzor.
Do not take Tribenzor if you are allergic to sulfonamide-derived drugs.
Do not take Tribenzor if you have not taken any other medications for your blood pressure before.
Cautions
WARNING: FETAL TOXICITY
See full prescribing information for complete boxed warnings.
When pregnancy is detected, discontinue Tribenzor as soon as possible.
Drugs that act directly on the renin-angiotensin system can cause injury and death to the developing fetus.
- Before you start taking Tribenzor, tell your doctor if you are pregnant, suspect that you are pregnant, or plan to become pregnant. Tribenzor may cause fetal toxicity that can result in injury or death to the fetus.
- Before you start taking Tribenzor, tell your doctor if you are breastfeeding or plan to start breastfeeding. Breastfeeding is not recommended while taking Tribenzor.
- Before you start taking Tribenzor, tell your doctor if you have:
- Kidney problems
- Liver problems
- Heart problems
- Diabetes
- Glaucoma
- Lupus
- Gout
- Diarrhea or vomiting
- Allergies
- Bronchial asthma
- Before you start taking Tribenzor, be sure to let your doctor know about any prescription and over-the-counter medications you take, including vitamins and supplements.
- Tribenzor can cause low blood pressure, which can make you feel dizzy or faint. You should avoid drinking alcohol with Tribenzor. Your blood pressure may drop too low if you drink alcohol. Monitor your blood pressure while taking Tribenzor.
Side Effects
Side effects may occur with Tribenzor. Tribenzor side effects including:
- Low blood pressure
- Dizziness
- Swelling of the hands or legs
- Swelling of the joints
- Fatigue
- Muscle spasms
- Nausea
- Nasopharyngitis
- Upper respiratory infections
- Urinary tract infection
- Diarrhea
References:
TRIBENZOR Prescribing Information. Basking Ridge, NJ: Daiichi Sankyo, Inc.; 2020.
Tribenzor (olmesartan medoxomil, amlodipine, hydrochlorothiazide). Accessed November 18, 2021.
Frequently Asked Questions about Tribenzor
What is Tribenzor and how does it work?
Tribenzor is a combination medication containing amlodipine (a calcium channel blocker), hydrochlorothiazide (a thiazide diuretic), and olmesartan (an angiotensin II receptor antagonist). It works by relaxing blood vessels, reducing fluid retention, and preventing blood vessels from narrowing, which together help lower blood pressure.
What is Tribenzor used for?
Tribenzor is primarily used to treat high blood pressure (hypertension), particularly in cases where other blood pressure medicines have not been effective.
Who should not take Tribenzor?
Individuals allergic to sulfa drugs, unable to urinate, or pregnant should not take Tribenzor. It is also advised against using Tribenzor if you have diabetes and are taking medications containing aliskiren.
What are the potential side effects of Tribenzor?
Side effects can range from common ones like dizziness, headaches, and nausea to severe ones like allergic reactions, worsening chest pain, kidney problems, and electrolyte imbalances. Always consult a doctor if you experience any severe side effects.
Are there any pre-existing conditions that require caution when taking Tribenzor?
Yes, individuals with kidney disease, liver disease, heart disease, electrolyte imbalances, low blood pressure, glaucoma, lupus, gout, diabetes, or a penicillin allergy should discuss these conditions with their doctor before taking Tribenzor.
How should Tribenzor be taken?
Tribenzor should be taken exactly as prescribed by your doctor, with or without food. It’s important to stay hydrated while taking it, and you may need to have your blood pressure checked regularly. Dosage may be adjusted by your doctor over time.
What is the dosage for Tribenzor?
The usual adult dose for hypertension ranges with a maximum recommended dose of Amlodipine 10 mg/Hydrochlorothiazide 25 mg/Olmesartan 40 mg per day. Dosage may be increased after 2 weeks based on the individual’s response.
What should be done in case of a missed dose or overdose?
If you miss a dose, take it as soon as you can, but skip it if it's almost time for your next dose. Do not take two doses at one time. In case of an overdose, seek emergency medical attention or call the Poison Help line.
Are there any restrictions on food, drink, or activities while taking Tribenzor?
Avoid potassium supplements or salt substitutes unless advised by a doctor. Alcohol may cause side effects. Hydrochlorothiazide in Tribenzor may increase the risk of skin cancer, so avoid excessive sun exposure and use sunscreen. Be cautious when getting up from a sitting or lying position to avoid dizziness.
How does Tribenzor interact with other medications?
Many drugs can interact with Tribenzor, including other blood pressure medications, insulin, steroids, potassium supplements, sedatives, opioids, cholesterol-lowering medicines, antibiotics, and NSAIDs like aspirin and ibuprofen. Always inform your doctor about all medications you are taking.
IMPORTANT NOTE: The above information is intended to increase awareness of health information and does not suggest treatment or diagnosis. This information is not a substitute for individual medical attention and should not be construed to indicate that use of the drug is safe, appropriate, or effective for you. See your health care professional for medical advice and treatment.Product Code : 13034
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