What is a Generic Drug?

A generic drug is a copy of the brand-name drug with the same dosage, safety, strength, quality, consumption method, performance, and intended use. Before generics become available on the market, the generic company must prove it has the same active ingredients as the brand-name drug and works in the same way and in the same amount of time in the body.

The only differences between generics and their brand-name counterparts is that generics are less expensive and may look slightly different (eg. different shape or color), as trademarks laws prevent a generic from looking exactly like the brand-name drug.

Generics are less expensive because generic manufacturers don't have to invest large sums of money to develop a drug. When the brand-name patent expires, generic companies can manufacture a copy of the brand-name and sell it at a substantial discount.

Trijardy XR (Empagliflozin/Linagliptin/Metformin HCI)


Trijardy XR (Empagliflozin/Linagliptin/Metformin HCI)

Prescription Required

12.5mg / 2.5mg / 1000mg
5mg / 2.5mg / 1000mg
10mg / 5mg / 1000mg
25mg / 5mg / 1000mg

You'll have option to make 4 interest-free payments by credit card once your order is confirmed using Sezzle

We don't have this generic product yet!

Sign up to get exclusive coupon discounts and be the first to be notified when we have this product available.

  • Product Details


    Trijardy XR is a combination of three diabetes medications: Jardiance (empagliflozin), Tradjenta (linagliptin), and metformin hydrochloride (HCl). Trijardy XR is used with diet and exercise to lower A1C in adults with type 2 diabetes.

    Fact Table




    US DailyMed, EU EMA



    Legal status


    Chemical Name

    Empagliflozin/Linagliptin/Metformin HCI

    Elimination half-life

    10–13 hours

    Dosage (Strength)

    12.5mg / 2.5mg / 1000mg, 5mg / 2.5mg / 1000mg, 10mg / 5mg / 1000mg, 25mg / 5mg / 1000mg


    Not recommended


    Trijardy XR

    Protein binding


    PubChem CID






    ATC code






    Routes of administration



    Trijardy XR (empagliflozin, linagliptin, and metformin hydrochloride extended-release) is available in the following oral tablet strengths:

    • 5 mg empagliflozin/2.5 mg linagliptin/1000 mg metformin HCl extended-release
    • 10 mg empagliflozin/5 mg linagliptin/1000 mg metformin HCl extended-release
    • 12.5 mg empagliflozin/2.5 mg linagliptin/1000 mg metformin HCl


    • 25 mg empagliflozin/5 mg linagliptin/1000 mg metformin HCl extended-release

    Your starting dose will depend on your current treatment and kidney function.

    Take Trijardy XR by mouth once daily with a morning meal. Swallow the tablet whole. Do not take more than 25 mg empagliflozin, 5 mg linagliptin, and 2000 mg metformin HCl.


    Trijardy XR contains the following active ingredients: empagliflozin, linagliptin, and metformin hydrochloride.


    Do not take Trijardy XR if you have severe kidney problems, end-stage kidney disease, or if you are on dialysis.

    Do not take Trijardy XR if you have metabolic acidosis such as diabetic ketoacidosis.

    Do not take Trijardy XR if you are allergic to empagliflozin, linagliptin, metformin, or any of its other ingredients.



    See full prescribing information for complete boxed warning.

    • Postmarketing cases of metformin-associated lactic acidosis have resulted in death, hypothermia, hypotension, and resistant bradyarrhythmias. Symptoms included malaise, myalgias, respiratory distress, somnolence, and abdominal pain. Laboratory abnormalities included elevated blood lactate levels, anion gap acidosis, increased lactate/pyruvate ratio; and metformin plasma levels generally greater than 5 mcg/mL.
    • Risk factors include renal impairment, concomitant use of certain drugs, age greater than 65 years old, radiological studies with contrast, surgery and other procedures, hypoxic states, excessive alcohol intake, and hepatic impairment. Steps to reduce the risk of and manage metformin-associated lactic acidosis in these high risk groups are provided in the Full Prescribing Information.
    • If lactic acidosis is suspected, discontinue TRIJARDY XR and institute general supportive measures in a hospital setting. Prompt hemodialysis is recommended.
    • Before you start taking Trijardy XR, tell your doctor:
      • About all the medications you take, including prescription, over-the-counter, vitamins, and herbal supplements
      • About your allergies
      • About your health conditions
      • If you are pregnant or have plans to become pregnant
      • If you are breastfeeding or have plans to breastfeed
      • Before you undergo iodinated contrast imaging procedures, talk to your doctor. Your doctor may decide to discontinue Trijardy XR before or at the time of your procedure.
    • Trijardy XR can cause inflammation of the pancreas. Contact your doctor right away if you experience severe and persistent stomach pain or pain in your abdomen to your back, with or without vomiting.
    • Trijardy XR can cause ketoacidosis, a condition in which ketones are elevated in your blood or urine. Seek emergency care right away if you experience nausea, vomiting, stomach pain, trouble breathing, and fatigue.
    • Trijardy XR can cause dehydration. Your risk may be higher if you have kidney problems, are 65 years old or older, are on a low sodium diet, or take blood pressure medications such as diuretics.
    • Trijardy XR can cause urinary tract infections. Contact your doctor right away if you experience burning when urinating, frequent urination, urge to urinate, lower stomach or pelvic pain, fever, nausea, vomiting, back pain, or blood in your urine.
    • Trijardy XR can cause a serious bacterial infection that can damage the tissue under the skin around your anus and genitals. Seek emergency care right away if you experience a fever, weakness, fatigue, general discomfort, and pain, tenderness, swelling, and redness of the skin around your anus and genitals.
    • Trijardy XR can cause a vaginal yeast infection. Contact your doctor if you experience odor from your vagina, vaginal discharge that is white or yellowish, and/or itching of your vagina.
    • Trijardy XR can cause a penile yeast infection. Contact your doctor if you experience redness, itching, or swelling of the penis, odorous discharge from the penis, or rash or pain of the penile skin.
    • Trijardy XR can cause a decrease in your vitamin B12 levels.
    • Trijardy XR can cause joint pain that may become severe.
    • Trijardy XR can cause a skin reaction. Contact your doctor right away if you develop blisters.
    • Trijardy XR can cause heart failure. Call your doctor right away if you experience breathing problems, swelling in the feet, ankles, or legs, rapid weight gain, and abnormal fatigue.

    Side Effects

    Like with any medication, Trijardy XR has the potential to cause side effects including but not limited to constipation, diarrhea, headache, stomach and intestinal inflammation, stuffy or runny nose, sore throat, upper respiratory tract infection, and urinary tract infection.

    Call your doctor right away if you develop side effects that bother you or won't go away.


    1. Trijardy XR. Ridgefield, CT: Boehringer Ingelheim Pharmaceuticals, Inc.; 2021.
    2. Trijardy XR (empagliflozin/linagliptin/metformin extended-release tablets). Accessed February 9, 2022.

    IMPORTANT NOTE: The above information is intended to increase awareness of health information and does not suggest treatment or diagnosis. This information is not a substitute for individual medical attention and should not be construed to indicate that use of the drug is safe, appropriate, or effective for you. See your health care professional for medical advice and treatment.

    Product Code : 13642

  • Product Reviews


Please wait while the page is loading. Do not hit refresh or the browser back button to avoid any loss of information.

If you have any questions or concerns, please contact our Customer Service team via the chat option on our website or calling us toll free at: 1-800-891-0844