What is a Generic Drug?
A generic drug is a copy of the brand-name drug with the same dosage, safety, strength, quality, consumption method, performance, and intended use. Before generics become available on the market, the generic company must prove it has the same active ingredients as the brand-name drug and works in the same way and in the same amount of time in the body.
The only differences between generics and their brand-name counterparts is that generics are less expensive and may look slightly different (eg. different shape or color), as trademarks laws prevent a generic from looking exactly like the brand-name drug.
Generics are less expensive because generic manufacturers don't have to invest large sums of money to develop a drug. When the brand-name patent expires, generic companies can manufacture a copy of the brand-name and sell it at a substantial discount.
Trintellix (Vortioxetine)
Also Known as Brintellix
Prescription Required
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Product Details
Description
TRINTELLEX (Vortioxetine) is a medication prescribed to treat Major Depressive Disorder. Do not use TRINTELLIX for anxiety since studies have not proven it safe and effective for anxiety.
TRINTELLIX works by increasing levels of serotonin, enhancing the activity of serotonin, and by mimicking serotonin in certain areas of the brain. Serotonin is a chemical that passes messages between brain cells and regulates mood. By increasing serotonergic activity, TRINTELLIX helps to treat Major Depressive Disorder.
Fact Table
Formula
C18H22N2S
License
US DailyMed, EU EMA, US FDA
Bioavailability
75%
Legal status
Rx-Only
Chemical Name
Vortioxetine
Elimination half-life
66 hours
Dosage (Strength)
5mg, 10mg, 15mg, 20mg
Pregnancy
Not recommended
Brands
Trintellix
Protein binding
98–99%
PubChem CID
9966051
MedlinePlus
a614003
ChEBI
76016
ATC code
N06AX26
DrugBank
DB09068
KEGG
D10184
Routes of administration
By mouth
Directions
Take TRINTELLIX exactly as prescribed by your doctor.
Start TRINTELLIX at 10 mg by mouth once daily. The TRINTELLIX dosage should be increased to between 15 mg to 20 mg once daily once tolerated. TheTRINTELLIX dose can be lowered to 5 mg once daily in those who have trouble tolerating higher doses.
Take TRINTELLIX with or without food.
Ingredients
The active ingredient in TRINTELLIX is vortioxetine.
Cautions
If you are taking multiple medications that increase levels of serotonin, you may be at higher risk of serotonin syndrome. Serotonin syndrome is a rare, but life-threatening condition caused by the interactions of multiple medications that increase serotonin to dangerous levels. Signs of serotonin syndrome may include agitation, confusion, shivering, racing heart rate, muscle twitching, and tremor. Stop taking TRINTELLIX immediately and call emergency services if you suspect serotonin syndrome.
TRINTELLIX can cause low blood sodium in certain people. Speak with your doctor if you are taking diuretic medications or have medical conditions that affect your fluid status like heart failure or renal impairment.
Use TRINTELLIX with caution if you are taking medications that increase the risk of gastrointestinal bleeding, including prescription or over-the-counter NSAIDs for pain.
Do not take TRINTELLIX as monotherapy if you have bipolar disorder as it may increase the risk of hypomanic or manic episodes.
Tell your doctor if you have narrow-angle glaucoma before starting TRINTELLIX as it may worsen this condition.
Side Effects
Common adverse reactions when taking TRINTELLIX include:
- Constipation
- DIzziness
- Nausea
- Vomiting
Discontinuing TRINTELLIX abruptly may cause headaches and muscle tension. When stopping the medication, speak with your doctor to discontinue the medication in a way that will avoid these adverse effects.
References
- Trintellix [package insert]. Deerfield, IL: Takeda Pharmaceuticals; 2014.
IMPORTANT NOTE: The above information is intended to increase awareness of health information and does not suggest treatment or diagnosis. This information is not a substitute for individual medical attention and should not be construed to indicate that use of the drug is safe, appropriate, or effective for you. See your health care professional for medical advice and treatment.Product Code : 13202
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