What is a Generic Drug?
A generic drug is a copy of the brand-name drug with the same dosage, safety, strength, quality, consumption method, performance, and intended use. Before generics become available on the market, the generic company must prove it has the same active ingredients as the brand-name drug and works in the same way and in the same amount of time in the body.
The only differences between generics and their brand-name counterparts is that generics are less expensive and may look slightly different (eg. different shape or color), as trademarks laws prevent a generic from looking exactly like the brand-name drug.
Generics are less expensive because generic manufacturers don't have to invest large sums of money to develop a drug. When the brand-name patent expires, generic companies can manufacture a copy of the brand-name and sell it at a substantial discount.
Trulance (Plecanatide)
Prescription Required
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Product Details
Description
Trulance (plecanatide) is a medication used for the treatment of chronic idiopathic constipation (CIC) and irritable bowel syndrome with constipation (IBS-C) in adults.
Fact Table
Formula
C65H104N18O26S4
License
US FDA, US DailyMed
Bioavailability
Not orally bioavailable in humans
Legal status
Rx-Only
Chemical Name
Plecanatide
Elimination half-life
Cannot be calculated
Dosage (Strength)
3mg
Pregnancy
Consult Doctor
Brands
Trulance
Protein binding
Little to no binding
PubChem CID
70693500
MedlinePlus
a617020
ChEBI
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ATC code
A06AX07
DrugBank
DB13170
KEGG
D09948
Routes of administration
By mouth
Directions
Trulance is available in 3 mg tablets. The tablets should be swallowed whole. Tell your doctor or pharmacist if you are unable to swallow the tablets whole or if you have a nasogastric or gastric feeding tube.
Recommended adult dosing:
CIC: 3 mg by mouth once daily with or without food
IBS-C: 3 mg by mouth once daily with or without food
Ingredients
The active ingredient in Trulance is plecanatide.
Contraindications
Do not give Trulance to children younger than 6 years old due to the risk of severe dehydration.
Do not take Trulance if you have or think you have a mechanical gastrointestinal obstruction.
Cautions
WARNING: RISK OF SERIOUS DEHYDRATION IN PEDIATRIC PATIENTS
See full prescribing information for complete boxed warning.
- TRULANCE is contraindicated in patients less than 6 years of age; in young juvenile mice, plecanatide caused death due to dehydration.
- Avoid use of TRULANCE in patients 6 years to less than 18 years of age.
- The safety and effectiveness of TRULANCE have not been established in patients less than 18 years of age.
- Before you start taking Trulance, tell your doctor:
- About your medical history and health conditions
- About your allergies
- About all the medications you take, including prescription, over-the-counter, vitamins, and herbal supplements
- If you are pregnant or plan to become pregnant
- If you are breastfeeding or plan to breastfeed
- Trulance has not proven to be safe or effective in patients less than 18 years old. Avoid use in these patients.
Side Effects
The most common side effect of Trulance is diarrhea. Diarrhea usually begins within the first month of taking Trulance and may become severe. If you experience severe diarrhea, stop taking Trulance and contact your doctor right away.
Diarrhea is not the only possible side effect of Trulance. Contact your doctor right away if you experience any side effects that are bothersome or won't go away.
References:
- Trulance Prescribing Information. Bridgewater, NJ: Salix Pharmaceuticals; 2021.
- Trulance (plecanatide). Important Safety Information. Accessed February 1, 2022.
IMPORTANT NOTE: The above information is intended to increase awareness of health information and does not suggest treatment or diagnosis. This information is not a substitute for individual medical attention and should not be construed to indicate that use of the drug is safe, appropriate, or effective for you. See your health care professional for medical advice and treatment.Product Code : 13591
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