What is a Generic Drug?

A generic drug is a copy of the brand-name drug with the same dosage, safety, strength, quality, consumption method, performance, and intended use. Before generics become available on the market, the generic company must prove it has the same active ingredients as the brand-name drug and works in the same way and in the same amount of time in the body.

The only differences between generics and their brand-name counterparts is that generics are less expensive and may look slightly different (eg. different shape or color), as trademarks laws prevent a generic from looking exactly like the brand-name drug.

Generics are less expensive because generic manufacturers don't have to invest large sums of money to develop a drug. When the brand-name patent expires, generic companies can manufacture a copy of the brand-name and sell it at a substantial discount.

Trulance (Plecanatide)


Trulance (Plecanatide)

Prescription Required


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  • Product Details


    Trulance (plecanatide) is a medication used for the treatment of chronic idiopathic constipation (CIC) and irritable bowel syndrome with constipation (IBS-C) in adults.

    Fact Table




    US FDA, US DailyMed


    Not orally bioavailable in humans

    Legal status


    Chemical Name


    Elimination half-life

    Cannot be calculated

    Dosage (Strength)



    Consult Doctor



    Protein binding

    Little to no binding

    PubChem CID






    ATC code






    Routes of administration

    By mouth


    Trulance is available in 3 mg tablets. The tablets should be swallowed whole. Tell your doctor or pharmacist if you are unable to swallow the tablets whole or if you have a nasogastric or gastric feeding tube.

    Recommended adult dosing:

    CIC: 3 mg by mouth once daily with or without food

    IBS-C: 3 mg by mouth once daily with or without food


    The active ingredient in Trulance is plecanatide


    Do not give Trulance to children younger than 6 years old due to the risk of severe dehydration.

    Do not take Trulance if you have or think you have a mechanical gastrointestinal obstruction.



    See full prescribing information for complete boxed warning.

    • TRULANCE is contraindicated in patients less than 6 years of age; in young juvenile mice, plecanatide caused death due to dehydration. 
    • Avoid use of TRULANCE in patients 6 years to less than 18 years of age. 
    • The safety and effectiveness of TRULANCE have not been established in patients less than 18 years of age. 
    • Before you start taking Trulance, tell your doctor:
      • About your medical history and health conditions
      • About your allergies
      • About all the medications you take, including prescription, over-the-counter, vitamins, and herbal supplements
      • If you are pregnant or plan to become pregnant
      • If you are breastfeeding or plan to breastfeed
    • Trulance has not proven to be safe or effective in patients less than 18 years old. Avoid use in these patients.

    Side Effects

    The most common side effect of Trulance is diarrhea. Diarrhea usually begins within the first month of taking Trulance and may become severe. If you experience severe diarrhea, stop taking Trulance and contact your doctor right away.

    Diarrhea is not the only possible side effect of Trulance. Contact your doctor right away if you experience any side effects that are bothersome or won't go away.


    1. Trulance Prescribing Information. Bridgewater, NJ: Salix Pharmaceuticals; 2021.
    2. Trulance (plecanatide). Important Safety Information. Accessed February 1, 2022.

    Frequently Asked Questions about Trulance (Plecanatide)

    What is Trulance used for?

    Trulance is a prescription medication for adults with chronic constipation or constipation caused by irritable bowel syndrome (IBS-C).

    How does it work?

    Trulance works by stimulating the natural movement of fluids in your gut, helping stool pass more easily.

    How is it taken?

    Trulance comes as a 3mg tablet, usually taken once daily with or without food. It can be swallowed whole, crushed and mixed with applesauce, or dissolved in water.

    How long does it take to work?

    Some people experience relief within the first 24 hours, while others may take a few days or weeks to see full effects.

    What are the common side effects?

    The most common side effects are diarrhea, bloating, gas, and abdominal pain. These are usually mild and temporary.

    Is it safe for everyone?

    Trulance is not suitable for children under 6, people with bowel blockages, or those allergic to its ingredients. Tell your doctor about any other medications or conditions you have before taking it.

    Can I take it with other medications?

    It's important to tell your doctor about all medications you're taking, including over-the-counter drugs and supplements, to avoid potential interactions.

    Is Trulance habit-forming?

    No, Trulance is not considered habit-forming.

    Does it affect pregnancy or breastfeeding?

    There is limited data on the safety of Trulance during pregnancy or breastfeeding. Talk to your doctor if you're considering taking it while pregnant or breastfeeding.

    What are the alternatives to Trulance?

    Other treatments for constipation include lifestyle changes, dietary adjustments, and other medications. Discuss all options with your doctor to find the best approach for you.

    IMPORTANT NOTE: The above information is intended to increase awareness of health information and does not suggest treatment or diagnosis. This information is not a substitute for individual medical attention and should not be construed to indicate that use of the drug is safe, appropriate, or effective for you. See your health care professional for medical advice and treatment.

    Product Code : 13591

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