Tyzeka (Telbivudine)
What is a Generic Drug?
A generic drug is a copy of the brand-name drug with the same dosage, safety, strength, quality, consumption method, performance, and intended use. Before generics become available on the market, the generic company must prove it has the same active ingredients as the brand-name drug and works in the same way and in the same amount of time in the body.
The only differences between generics and their brand-name counterparts is that generics are less expensive and may look slightly different (eg. different shape or color), as trademarks laws prevent a generic from looking exactly like the brand-name drug.
Generics are less expensive because generic manufacturers don't have to invest large sums of money to develop a drug. When the brand-name patent expires, generic companies can manufacture a copy of the brand-name and sell it at a substantial discount.
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Prescription Required
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Product Details
Description
Your doctor may prescribe Tyzeka for the treatment of chronic hepatitis B disease. Hepatitis B is a viral infection of the liver. The disease is often chronic and can last for several years. Hepatitis B virus infects the liver and can cause liver damage over time.
Tyzeka works by incorporating into the genetic material of the hepatitis B virus. By doing so, it prevents viral replication and helps to slow the infections. By slowing viral replication, it gives the immune system the chance to fight the infecftion.
Fact Table
Formula
C10H14N2O5
License
US FDA, EU EMA
Bioavailability
68%
Legal status
Rx-only
Chemical Name
Telbivudine
Elimination half-life
40 to 49 hours
Dosage (Strength)
600mg
Pregnancy
No Known Risk
Brands
Tyzeka, Sebivo
Protein binding
Low
PubChem CID
159269
MedlinePlus
a607045
ChEBI
63624
ATC code
J05AF11
DrugBank
DB01265
KEGG
D06675
Routes of administration
By mouth
Directions
The usual dosage for adults is 600 mg by mouth once daily.
The dose may be adjusted for people with kidney problems.
Ingredients
The active ingredient in Tyzeka is telbivudine.
Interactions
Tell your doctor and pharmacist if you are taking any of the following drugs prior to starting Tyzeka:
- Cladribine
- Interferons
- Peginterferon Alfa-2a
Cautions
Tell your doctor if you have a history of lactic acidosis before you start this drug as it can increase the risk of developing this condition.
Do not stop taking this drug without first speaking with your doctor.
Tyzeka can increase the risk of myopathy and peripheral neuropathy. Speak with your doctor if you have a history of these conditions.
Side Effects
The most common side effects of this medication include:
- Abdominal distension
- Abdominal pain
- Arthralgia
- Back pain
- Cough
- Diarrhea
- Dizziness
- Dyspepsia
- Exacerbation of hepatitis B
- Fatigue
- Fever
- Headache
- Hepatomegaly
- Hyperbilirubinemia
- Hypoesthesia
- Increased amylase
- Increased creatine phosphokinase
- Increased serum ALT
- Increased serum AST
- Increased serum lipase
- Insomnia
- Lactic acidosis
- Liver steatosis
- Myalgia
- Myopathy
- Myositis
- Nausea
- Neutropenia
- Paresthesia
- Peripheral neuropathy
- Pharyngolaryngeal pain
- Pruritus
- Rhabdomyolysis
- Skin rash
- Thrombocytopenia
References
Telbivudine [package insert]. East Hanover, NJ: Novartis Pharmaceuticals Corp; 2013.
IMPORTANT NOTE: The above information is intended to increase awareness of health information and does not suggest treatment or diagnosis. This information is not a substitute for individual medical attention and should not be construed to indicate that use of the drug is safe, appropriate, or effective for you. See your health care professional for medical advice and treatment.Product Code : 11622
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