What is a Generic Drug?
A generic drug is a copy of the brand-name drug with the same dosage, safety, strength, quality, consumption method, performance, and intended use. Before generics become available on the market, the generic company must prove it has the same active ingredients as the brand-name drug and works in the same way and in the same amount of time in the body.
The only differences between generics and their brand-name counterparts is that generics are less expensive and may look slightly different (eg. different shape or color), as trademarks laws prevent a generic from looking exactly like the brand-name drug.
Generics are less expensive because generic manufacturers don't have to invest large sums of money to develop a drug. When the brand-name patent expires, generic companies can manufacture a copy of the brand-name and sell it at a substantial discount.
Uloric (Febuxastat)
Prescription Required
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Product Details
Description
Uloric is a prescription medication given to treat hyperuricemia, which is excess uric acid that leads to gout attacks.
Symptoms of gout are located in the joints, particularly the toe, ankle, foot, and knee joints. Symptoms may include stiffness, swelling, pain, and lumps.
Uloric works by decreasing the amount of uric acid circulating in the bloodstream, which reduces the formation of uric acid crystals in the joints. Uloric belongs to the class of medications Xanthine Oxidase Inhibitors.
Fact Table
Formula
C16H16N2O3S
License
US FDA
Bioavailability
49%
Legal status
US: RX Only
Chemical Name
Febuxastat
Elimination half-life
5 to 8 hours
Dosage (Strength)
40mg, 80mg
Pregnancy
No known risks
Brands
Uloric and Adenuric
Protein binding
99% %
PubChem CID
134018
MedlinePlus
a609020
ChEBI
31596
ATC code
M04AA03
DrugBank
DB04854
KEGG
D01206
Routes of administration
By mouth (tablets)
Directions
The starting dose of Uloric is 40 mg by mouth once daily. Your prescriber may increase the dose to 80 mg after two weeks if the response to medication is inadequate. It can be increased one more time if needed to 120 mg once daily.
Your dosage may need to be adjusted if you have kidney problems.
Ingredients
The active ingredient in Uloric is Febuxostat, which is also the name for Uloric generic.
Interactions
Uloric has drug-drug interactions with the following medications:
- Azathioprine
- Didanosine
- Mercaptopurine
- Methotrexate
- Pegloticase
- Theophylline
Cautions
Patients with established cardiovascular disease should not use Uloric unless directed by their physician. Cardiovascular disease is associated with a higher rate of cardiovascular death compared to other agents used to treat gout.
When starting Uloric, gout flares may initially increase. Additional gout medications may be used to help prevent this.
Tell your doctor if you have a history of heart or liver problems before starting Uloric.
Side Effects
Common Uloric side effects may include:
- Acute gout attack
- Arthralgia
- Hepatic insufficiency
- Increased liver enzymes
- Nausea
- Skin rash
References
Uloric [package insert]. Deerfield, IL: Takeda; 2017.
IMPORTANT NOTE: The above information is intended to increase awareness of health information and does not suggest treatment or diagnosis. This information is not a substitute for individual medical attention and should not be construed to indicate that use of the drug is safe, appropriate, or effective for you. See your health care professional for medical advice and treatment.Product Code : 11357
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