Description
Uloric is a prescription medication given to treat hyperuricemia, which is excess uric acid that leads to gout attacks.
Symptoms of gout are located in the joints, particularly the toe, ankle, foot, and knee joints. Symptoms may include stiffness, swelling, pain, and lumps.
Uloric works by decreasing the amount of uric acid circulating in the bloodstream, which reduces the formation of uric acid crystals in the joints. Uloric belongs to the class of medications Xanthine Oxidase Inhibitors.
Fact Table |
Formula |
C16H16N2O3S |
License |
US FDA |
Bioavailability |
49% |
Legal status |
US: RX Only |
Chemical Name |
Febuxastat |
Elimination half-life |
5 to 8 hours |
Dosage (Strength) |
40mg, 80mg |
Pregnancy |
No known risks |
Brands |
Uloric and Adenuric |
Protein binding |
99% % |
PubChem CID |
134018 |
MedlinePlus |
a609020 |
ChEBI |
31596 |
ATC code |
M04AA03 |
DrugBank |
DB04854 |
KEGG |
D01206 |
Routes of administration |
By mouth (tablets) |
Directions
The starting dose of Uloric is 40 mg by mouth once daily. Your prescriber may increase the dose to 80 mg after two weeks if the response to medication is inadequate. It can be increased one more time if needed to 120 mg once daily.
Your dosage may need to be adjusted if you have kidney problems.
Ingredients
The active ingredient in Uloric is Febuxostat, which is also the name for Uloric generic.
Interactions
Uloric has drug-drug interactions with the following medications:
- Azathioprine
- Didanosine
- Mercaptopurine
- Methotrexate
- Pegloticase
- Theophylline
Cautions
Patients with established cardiovascular disease should not use Uloric unless directed by their physician. Cardiovascular disease is associated with a higher rate of cardiovascular death compared to other agents used to treat gout.
When starting Uloric, gout flares may initially increase. Additional gout medications may be used to help prevent this.
Tell your doctor if you have a history of heart or liver problems before starting Uloric.
Side Effects
Common Uloric side effects may include:
- Acute gout attack
- Arthralgia
- Hepatic insufficiency
- Increased liver enzymes
- Nausea
- Skin rash
References
Uloric [package insert]. Deerfield, IL: Takeda; 2017.
About Dr. Conor Sheehy (Page Author)
Dr. Sheehy (BSc Molecular Biology, PharmD) works a clinical pharmacist specializing in cardiology, oncology, and ambulatory care. He’s a board-certified pharmacotherapy specialist (BCPS), and his experience working one-on-one with patients to fine tune their medication and therapy plans for optimal results makes him a valuable subject matter expert for our pharmacy. Read More....
IMPORTANT NOTE:
The above information is intended to increase awareness of health information and does not suggest treatment or diagnosis. This information is not a substitute for individual medical attention and should not be construed to indicate that use of the drug is safe, appropriate, or effective for you. See your health care professional for medical advice and treatment.
Product Code : 11357