What is a Generic Drug?
A generic drug is a copy of the brand-name drug with the same dosage, safety, strength, quality, consumption method, performance, and intended use. Before generics become available on the market, the generic company must prove it has the same active ingredients as the brand-name drug and works in the same way and in the same amount of time in the body.
The only differences between generics and their brand-name counterparts is that generics are less expensive and may look slightly different (eg. different shape or color), as trademarks laws prevent a generic from looking exactly like the brand-name drug.
Generics are less expensive because generic manufacturers don't have to invest large sums of money to develop a drug. When the brand-name patent expires, generic companies can manufacture a copy of the brand-name and sell it at a substantial discount.
Vastarel MR (Trimetazidine)
Also Known as Vastarel MR
Prescription Required
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Product Details
Description
Your doctor may prescribe Vastarel MR to manage angina, a condition where not enough oxygen gets to cardiac muscle, causing chest pain.
Vastarel MR works by improving myocardial glucose utilization and inhibiting fatty acid oxidation. This mechanism optimizes cellular energy metabolism, safeguarding the heart against ischemia and inadequate blood supply.
Fact Table
Formula
C14H22N2O3
License
EMA
Bioavailability
~90%
Legal status
Prescription only (?)
Chemical Name
1-(2,3,4-trimethoxybenzyl)piperazine dihydrochloride
Elimination half-life
6 hours
Dosage (Strength)
35 mg modified-release tablets
Pregnancy
Not recommended
Brands
Vastarel MR
Protein binding
16%
PubChem CID
5546
MedlinePlus
a682992
ChEBI
CHEBI: 322963
ATC code
C01EB15
DrugBank
DB09270
KEGG
D08691
Routes of administration
Oral
Directions
The recommended dosage for Vastarel MR is 35 mg orally twice daily, to be taken with meals.
Ingredients
The active ingredient in Vastarel MR is trimetazidine.
Interactions
Drug-drug interactions for Vastarel MR are not well known. Based on how this drug works, it is likely to interact with antipsychotics, antihypertensives, and medications for angina. Example include:
Amlodipine
Aripiprazole
Atenolol
Clozapine
Diltiazem
Haloperidol
Hydrochlorothiazide
Isosorbide dinitrate
Isosorbide mononitrate
Lisinopril
Losartan
Metoprolol
Nitroglycerin
Olanzapine
Quetiapine
Ranolazine
Risperidone
Valsartan
Verapamil
Ziprasidone
Cautions
Although Vastarel MR is not approved for use in the United States, it has approval in some other countries.
The European Medicines Agency (EMA) advises against its use for tinnitus, vertigo, or vision disturbances.
Caution is warranted when prescribing Vastarel MR to individuals with movement disorders such as Parkinson's disease, parkinsonian symptoms, tremors, restless legs syndrome (RLS), and other related conditions.
Side Effects
Abdominal pain
Constipation
Diarrhea
Difficulty sleeping
Dizziness
Drowsiness
Extrapyramidal symptoms (unusual movements, including trembling and shaking of the hands and fingers, twisting movements of the body, shuffling walk, and stiffness of the arms and legs), usually reversible after treatment discontinuation
Extra heartbeats
Fainting
Fall
Fast or irregular heartbeats (palpitations)
Faster heartbeat
Feeling of weakness
Feeling sick (nausea)
Flushing
Headache
Hives
Indigestion
Itching
Leukopenia
Lightheadedness
Liver disease
Low blood pressure
Malaise (generally feeling unwell)
Rash
Red skin rash with blistering
Swelling of the face, lips, mouth, tongue, or throat, which may cause difficulty in swallowing or breathing
Thrombocytopenia
Vertigo
Vomiting
References
Vastarel MR [package insert]. Giddy, France: Les Laboratories; February 2021.
IMPORTANT NOTE: The above information is intended to increase awareness of health information and does not suggest treatment or diagnosis. This information is not a substitute for individual medical attention and should not be construed to indicate that use of the drug is safe, appropriate, or effective for you. See your health care professional for medical advice and treatment.Product Code : 12271
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