What is a Generic Drug?
A generic drug is a copy of the brand-name drug with the same dosage, safety, strength, quality, consumption method, performance, and intended use. Before generics become available on the market, the generic company must prove it has the same active ingredients as the brand-name drug and works in the same way and in the same amount of time in the body.
The only differences between generics and their brand-name counterparts is that generics are less expensive and may look slightly different (eg. different shape or color), as trademarks laws prevent a generic from looking exactly like the brand-name drug.
Generics are less expensive because generic manufacturers don't have to invest large sums of money to develop a drug. When the brand-name patent expires, generic companies can manufacture a copy of the brand-name and sell it at a substantial discount.
Velcade (Bortezomib)
Prescription Required
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Product Details
Description
Velcade is a prescription medication primarily used to treat multiple myeloma, a type of cancer that affects plasma cells in the bone marrow. It is also indicated for treating mantle cell lymphoma, a rare type of non-Hodgkin's lymphoma.
Velcade contains the active ingredient bortezomib, which belongs to a class of drugs called proteasome inhibitors. It works by blocking the action of proteasomes, which are cellular structures that break down proteins. By inhibiting proteasomes, Velcade interferes with the survival of cancer cells, leading to their death.
Fact Table
Formula
C19H25BN4O4
License
US FDA, EMA
Bioavailability
32% (subcutaneous)
Legal status
Prescription only (?)
Chemical Name
[(1R)-3-methyl-1-[[(2S)-1-oxo-3-phenyl-2-[(pyrazinylcarbonyl)amino]propyl]amino]butyl]boronic acid
Elimination half-life
40-193 hours
Dosage (Strength)
3.5 mg/vial for injection
Pregnancy
Contraindicated
Brands
Velcade
Protein binding
83%
PubChem CID
387447
MedlinePlus
a607007
ChEBI
CHEBI:41262
ATC code
L01XX32
DrugBank
DB00188
KEGG
D04101
Routes of administration
Intravenous, Subcutaneous
Directions
A trained healthcare professional administers Velcade in a clinic or infusion setting. Your healthcare provider determines the dose.
Ingredients
The active ingredient in Velcade is bortezomib.
Interactions
Common drug-drug interactions may include:
- Adenovirus Vaccine, Live
- Apalutamide
- Bacillus of Calmette and Guerin Vaccine, Live
- Carbamazepine
- Cholera Vaccine, Live
- Dengue Tetravalent Vaccine, Live
- Ebola Zaire Vaccine, Live
- Enzalutamide
- Fosphenytoin
- Influenza Virus Vaccine, Live
- Itraconazole
- Levoketoconazole
- Lumacaftor
- Measles Virus Vaccine, Live
- Methotrexate
- Mitotane
- Mumps Virus Vaccine, Live
- Phenytoin
- Poliovirus Vaccine, Live
- Rifampin
- Rotavirus Vaccine, Live
- Rubella Virus Vaccine, Live
- Smallpox Monkeypox Vaccine, Live Non-Replicating
- Smallpox Vaccine
- St John's Wort
- Typhoid Vaccine, Live
- Varicella Virus Vaccine, Live
- Yellow Fever Vaccine
Cautions
Before starting Velcade treatment, discussing any pre-existing medical conditions or concerns with your healthcare provider is important. Tell your doctor if you have a history of peripheral neuropathy, heart disease, liver disease, kidney disease, lung disease, or herpes zoster.
Do not use Velcade if you are pregnant or planning to become pregnant.
Side Effects
The most common adverse reactions are:
- Anemia, All grades
- Arthralgia
- Asthenia
- Bone pain
- Constipation
- Cough
- Cramp
- Diarrhea
- Dizziness
- Dyspnea
- Dysesthesia
- Fatigue
- Fever
- Headache
- Heart disease
- Heart failure
- Leukopenia, All grades
- Loss of appetite
- Lower respiratory tract infection
- Lymphocytopenia, All grades
- Myalgia
- Nausea
- Neuralgia
- Neutropenia, All grades
- Paresthesia
- Peripheral neuropathy
- Rash
- Thrombocytopenia, All grades
- Vomiting
References
Velcade [package insert]. Cambridge, MA: Millennium Pharmaceuticals; June 2008.
IMPORTANT NOTE: The above information is intended to increase awareness of health information and does not suggest treatment or diagnosis. This information is not a substitute for individual medical attention and should not be construed to indicate that use of the drug is safe, appropriate, or effective for you. See your health care professional for medical advice and treatment.Product Code : 10753
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