What is a Generic Drug?
A generic drug is a copy of the brand-name drug with the same dosage, safety, strength, quality, consumption method, performance, and intended use. Before generics become available on the market, the generic company must prove it has the same active ingredients as the brand-name drug and works in the same way and in the same amount of time in the body.
The only differences between generics and their brand-name counterparts is that generics are less expensive and may look slightly different (eg. different shape or color), as trademarks laws prevent a generic from looking exactly like the brand-name drug.
Generics are less expensive because generic manufacturers don't have to invest large sums of money to develop a drug. When the brand-name patent expires, generic companies can manufacture a copy of the brand-name and sell it at a substantial discount.
Verquvo (Vericiguat)
Prescription Required
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Product Details
Description
Verquvo (vericiguat) is used to decrease the risk of cardiovascular death and heart failure hospitalization in patients who are experiencing symptoms of long-lasting heart failure with an ejection fraction less than 45% and have recently been hospitalized or received IV medications for heart failure.
Verquvo is classified as a soluble guanylate cyclase (sGC) stimulator.
Fact Table
Formula
C19H16F2N8O2
License
US DailyMed
Bioavailability
93%
Legal status
Rx-Only
Chemical Name
Vericiguat
Elimination half-life
30 hours
Dosage (Strength)
2.5mg, 5mg, 10mg
Pregnancy
Not Recommended
Brands
Verquvo
Protein binding
98%
PubChem CID
54674461
MedlinePlus
a621014
ChEBI
142432
ATC code
C01DX22
DrugBank
DB15456
KEGG
D11051
Routes of administration
By mouth
Directions
Verquvo is available in 2.5 mg, 5 mg, and 10 mg tablets.
The recommended initial dose is 2.5 mg by mouth one time a day with food. The tablets can be crushed and mixed with water if you are unable to swallow the tablets whole.
Your doctor may change your dose depending on how well you respond to the medication.
Ingredients
Each tablet contains the active ingredient, vericiguat.
Contraindications
Do not take Verquvo if you are taking another sGC stimulator. If you are not sure if you are taking an sGC stimulator, ask your doctor.
Do not take Verquvo if you are pregnant.
Cautions
WARNING: EMBRYO-FETAL TOXICITY
See full prescribing information for complete boxed warning.
- Do not administer VERQUVO to a pregnant female because it may cause fetal harm.
- Females of reproductive potential: Exclude pregnancy before the start of treatment. To prevent pregnancy, females of reproductive potential must use effective forms of contraception during treatment and for one month after stopping treatment.
- Before you start taking Verquvo, inform your doctor:
- Of all the medications you take. These include prescription and over-the-counter medicines, vitamins, and herbal supplements.
- Of your allergies.
- Of your health conditions.
- If you are pregnant or have plans to become pregnant.
- If you are breastfeeding or have plans to breastfeed.
Side Effects
The most common side effects of Verquvo include low blood pressure and anemia.
Call your doctor right away if you experience negative or persistent side effects.
Reference:
Verquvo. Whitehouse Station, NJ: Merck & Co., Inc.; 2021.
IMPORTANT NOTE: The above information is intended to increase awareness of health information and does not suggest treatment or diagnosis. This information is not a substitute for individual medical attention and should not be construed to indicate that use of the drug is safe, appropriate, or effective for you. See your health care professional for medical advice and treatment.Product Code : 13638
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