What is a Generic Drug?
A generic drug is a copy of the brand-name drug with the same dosage, safety, strength, quality, consumption method, performance, and intended use. Before generics become available on the market, the generic company must prove it has the same active ingredients as the brand-name drug and works in the same way and in the same amount of time in the body.
The only differences between generics and their brand-name counterparts is that generics are less expensive and may look slightly different (eg. different shape or color), as trademarks laws prevent a generic from looking exactly like the brand-name drug.
Generics are less expensive because generic manufacturers don't have to invest large sums of money to develop a drug. When the brand-name patent expires, generic companies can manufacture a copy of the brand-name and sell it at a substantial discount.
Vfend (Voriconazole)
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Product Details
Description
Vfend (voriconazole) is a medication used for the treatment of certain fungal infections in adults and pediatrics who are at least 2 years old.
Fact Table
Formula
C16H14F3N5O
License
US DailyMed, EU EMA, US FDA
Bioavailability
96%
Legal status
Rx-only
Chemical Name
Voriconazole
Elimination half-life
Dose-dependent
Dosage (Strength)
50mg
Pregnancy
Not Recommended
Brands
Vfend
Protein binding
58%
PubChem CID
71616
MedlinePlus
a605022
ChEBI
10023
ATC code
J02AC03
DrugBank
DB00582
KEGG
D00578
Routes of administration
By mouth
Directions
Follow your prescription's instructions. Talk to your doctor or pharmacist about any questions you may have.
Vfend is available in 50 mg tablets, 200 mg tablets, and a 40 mg/mL oral suspension.
Maintenance Dose in Adults Who Weigh 40 kg or More
200 mg by mouth every 12 hours
Maintenance Dose in Adults Who Weigh Less Than 40 kg
100 mg or 150 mg by mouth every 12 hours
Maintenance Dose in Pediatric Patients Who are 2 Years Old to Less Than 12 Years Old
9 mg per kg by mouth every 12 hours (maximum 350 mg every 12 hours)
Maintenance Dose in Pediatric Patients Who are 12 to 14 Years Old and Weigh Less Than 50 kg
9 mg per kg by mouth every 12 hours (maximum 350 mg every 12 hours)
Maintenance Dose in Pediatric Patients Who are 12 to 14 Years Old and Weigh 50 kg or More:
Use adult dose
Maintenance Dose in Pediatric Patients Who are 15 Years Old and Older
Use adult dose
The dose may be adjusted in adults who have liver or kidney problems.
Store Vfend tablets and oral suspension at room temperature. Discard the suspension after 14 days.
Before using the suspension, shake the bottle for about 10 seconds. Use the oral dropper supplied with the oral suspension.
Ingredients
Voriconazole is the active ingredient in Vfend.
Croscarmellose sodium, lactose monohydrate, magnesium stearate, povidone, pregelatinized starch, and a coating containing hypromellose, lactose monohydrate, titanium dioxide, and triacetin are the inactive ingredients in Vfend tablets.
Anhydrous citric acid, colloidal silicon dioxide, natural orange flavor, sodium benzoate, sodium citrate dihydrate, sucrose, titanium dioxide, and xanthan gum are the inactive ingredients in the Vfend oral suspension.
Contraindications
Do not take Vfend if you are allergic to voriconazole or any of the other ingredients or excipients in Vfend.
Do not take Vfend with pimozide, quinidine, sirolimus, or ivabradine as drug interactions may occur and cause serious reactions. Ask your doctor if you are unsure whether or not you take any of these medications.
Do not take Vfend with rifampin, carbamazepine, long-acting barbiturates, efavirenz, ritonavir, rifabutin, ergot alkaloids, and St. John's Wort as this may cause the medication not to work well. Ask your doctor if you are unsure whether or not you take any of these medications.
Do not take Vfend with naloxegol, tolvaptan, and lurasidone as drug interactions may occur and cause serious reactions. Ask your doctor if you are unsure whether or not you take any of these medications.
Do not take Vfend with venetoclax at the start of and during the ramp up phase in patients who have chronic lymphocytic leukemia (CLL) or small lymphocytic lymphoma (SLL) as drug interactions may occur and cause serious reactions. Ask your doctor if you are unsure whether or not you take venetoclax.
Cautions
- Before you start treatment with Vfend, discuss the following with your doctor:
- Your allergies
- Your health problems
- All the medications you take, including prescription, over-the-counter, vitamins, and herbal supplements.
- If you are pregnant, think you are pregnant, or plan to get pregnant
- If you are nursing or plan to nurse your baby
- Vfend can cause liver dysfunction or injury. Liver function should be monitored.
- Vfend can cause arrhythmias and QT prolongation. Discuss any risks with your doctor.
- Vfend can cause vision problems. Your vision should be checked if you're taking Vfend for more than 28 days.
- Vfend can cause severe exfoliative cutaneous reactions.
- Vfend can cause photosensitivity. You should avoid sunlight exposure and use protective clothing and sunscreen with a high SPF.
- Vfend can cause kidney problems or injury. Kidney function should be monitored.
- Vfend can cause adrenal dysfunction.
- Vfend can cause harm to an unborn baby.
- Vfend can cause electrolyte abnormalities.
- Vfend can cause pancreatitis.
- Vfend can cause skeletal reactions such as fluorosis and periostitis.
- Vfend can cause intolerance to galactose. Do not take Vfend if you have glucose intolerance, Lapp lactase deficiency, or glucose-galactose malabsorption.
Side Effects
The most common side effects observed in adult patients include vision problems, fever, nausea, rash, vomiting, chills, headache, abnormal liver function tests, rapid heart rate, and hallucinations.
The most common side effects observed in pediatric patients include vision problems, fever, vomiting, nosebleeds, nausea, rash, stomach pain, diarrhea, high blood pressure, low potassium levels in the blood, cough, headache, low platelet levels, abnormal ALT, low blood pressure, peripheral edema, high blood glucose levels, rapid heart rate, shortness of breath, low calcium levels in the blood, low phosphorus levels in the blood, abnormal LFT, mucosal inflammation, eye discomfort in the presence of bright lights, abdominal distention, constipation, dizziness, hallucinations, coughing up blood, low albumin levels, low magnesium levels in the blood, kidney problems, and upper respiratory tract infection.
If you experience side effects that concern you or will not go away, let your doctor know right away.
Reference:
- Vfend (voriconazole). New York, NY: Pfizer, Inc.; 2022.
IMPORTANT NOTE: The above information is intended to increase awareness of health information and does not suggest treatment or diagnosis. This information is not a substitute for individual medical attention and should not be construed to indicate that use of the drug is safe, appropriate, or effective for you. See your health care professional for medical advice and treatment.Product Code : 9749
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