What is a Generic Drug?
A generic drug is a copy of the brand-name drug with the same dosage, safety, strength, quality, consumption method, performance, and intended use. Before generics become available on the market, the generic company must prove it has the same active ingredients as the brand-name drug and works in the same way and in the same amount of time in the body.
The only differences between generics and their brand-name counterparts is that generics are less expensive and may look slightly different (eg. different shape or color), as trademarks laws prevent a generic from looking exactly like the brand-name drug.
Generics are less expensive because generic manufacturers don't have to invest large sums of money to develop a drug. When the brand-name patent expires, generic companies can manufacture a copy of the brand-name and sell it at a substantial discount.
Viekira (Ombitasvir/Paritaprevir/Ritonavir/Dasabuvir)
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Product Details
Description
What is VIEKIRA?
- Viekira (ombitasvir/paritaprevir/ritonavir/dasabuvir) is a combination medication used to treat hepatitis C.
How does it work?
- The drugs contained in Viekira work together to disrupt the replication processes used by hepatitis C.
How is it supplied?
- Viekira comes in a pack, called the Viekira Pak. The Viekira Pak contains:
- Combination tablets containing ombitasvir 12.5mg/paritaprevir 75mg/ritonavir 50mg
- Dasabuvir 250mg tablets
How should I store it?
- Store your Viekira at room temperature and keep it out of reach of children.
Directions
Should I take it with food?
- Yes, you should take Viekira with a meal.
Are there any special instructions for taking VIEKIRA?
- Your doctor could adjust your dose, depending on the type of hepatitis C. virus and your liver function.
- Your doctor could use Viekira in combination with ribavirin. Take your prescriptions exactly as your doctor writes them.
What is the usual dose?
- Viekira Pak dosing works as follows:
- Take two ombitasvir/paritaprevir/ritonavir tablets by mouth once per day in the morning, and
- Take one dasabuvir tablet by mouth twice daily.
Ingredients
What are the active ingredients?
- Ombitasvir
- Paritaprevir
- Ritonavir
- Dasabuvir
What are the inactive ingredients?
- For a full list of inactive ingredients, see the package insert.
Fact Table
Formula
Ombitasvir: C50H67N7O8, Paritaprevir: C40H43N7O7S, Ritonavir: C37H48N6O5S2, Dasabuvir: C26H27N3O5S
License
EU EMA, US FDA
Bioavailability
Varies, 70%
Legal status
RX Only
Chemical Name
Ombitasvir, Paritaprevir, Ritonavir, Dasabuvir
Elimination half-life
Ombitasvir: 21 – 25 hours, Paritaprevir: 5.5 hours, Ritonavir: 3-5 hours, Dasabuvir: 5.5- 6 hours
Dosage (Strength)
12.5/75/50mg (28 ampules)
Pregnancy
Consult a doctor
Brands
Viekira Pak, Exviera,Norvir, Kaletra
Protein binding
Ombitasvir: 99.9%, Paritaprevir: 97-98.6%, Ritonavir: 98-99%, Dasabuvir: less than 99.5%
PubChem CID
Ombitasvir: 54767916, Paritaprevir: 45110509, Ritonavir: 392622, Dasabuvir: 56640146
MedlinePlus
a614057
ChEBI
Ombitasvir: 85183, Paritaprevir: 85188, Ritonavir: 45409, Dasabuvir: 85182
ATC code
J05AP52
DrugBank
Ombitasvir: DB09296, Paritaprevir: DB09297, Ritonavir: DB00503, Dasabuvir: DB09183
KEGG
Ombitasvir: D10576, Paritaprevir: D10580, Ritonavir: D00427, Dasabuvir: D10553
Routes of administration
By mouth
Cautions
Who should avoid taking VIEKIRA?
- Viekira can have severe drug interactions with several drugs. Tell your doctor about every medication you take, including over the counter drugs. See Section 4 of the package insert for a full list of medications that must be avoided while taking Viekira.
- You should not take Viekira if:
- You are allergic to any of the ingredients listed in the package insert.
- You have severe liver disease.
What are the risks associated with taking VIEKIRA?
- Viekira has a black box warning regarding hepatitis B infection. If you have ever had hepatitis B, taking Viekira can increase your risk of reactivation of the infection. Your doctor should monitor you closely if you have ever had hepatitis B.
- Viekira can have adverse effects on your liver. Your doctor should monitor your liver function periodically. They could decide to stop your treatment if you develop complications.
- Women who use birth control products containing ethinyl estradiol should stop taking their birth control before starting Viekira. Progesterone-only birth control products and non-hormonal products are safe options.
- If you are pregnant or considering becoming pregnant, discuss the risks with your physician. You should avoid becoming pregnant if your doctor as prescribed ribavirin as a combination treatment.
- Viekira therapy can lead to treatment resistance in patients who are infected with HIV. Your doctor should use additional HIV medications to reduce your risk of developing treatment-resistant HIV.
Side Effects
What are the common Viekira Pak side effects?
- Itching
- Nausea
- Insomnia
- Fatigue
What are the serious Viekira Pak side effects?
- Increased liver enzymes
- Liver injury
- Liver failure
- Hepatitis B reactivation
Other Considerations
- Compare the Viekira Pak price at Canada Pharmacy to your local drug store.
IMPORTANT NOTE: The above information is intended to increase awareness of health information and does not suggest treatment or diagnosis. This information is not a substitute for individual medical attention and should not be construed to indicate that use of the drug is safe, appropriate, or effective for you. See your health care professional for medical advice and treatment.Product Code : 13254
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