What is a Generic Drug?

A generic drug is a copy of the brand-name drug with the same dosage, safety, strength, quality, consumption method, performance, and intended use. Before generics become available on the market, the generic company must prove it has the same active ingredients as the brand-name drug and works in the same way and in the same amount of time in the body.

The only differences between generics and their brand-name counterparts is that generics are less expensive and may look slightly different (eg. different shape or color), as trademarks laws prevent a generic from looking exactly like the brand-name drug.

Generics are less expensive because generic manufacturers don't have to invest large sums of money to develop a drug. When the brand-name patent expires, generic companies can manufacture a copy of the brand-name and sell it at a substantial discount.

Vimovo (Naproxen/Esomeprazole Mag Trihydrate)


Vimovo (Naproxen/Esomeprazole Mag Trihydrate)

Prescription Required

375 / 20mg
500 / 20mg

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  • Product Details


    Your doctor may prescribe Vimovo to relieve the pain symptoms caused by osteoarthritis, rheumatoid arthritis, and ankylosing spondylitis.

    Vimovo contains two active ingredients: naproxen, a nonsteroidal anti-inflammatory drug (NSAID), and esomeprazole, a proton pump inhibitor (PPI). Naproxen and other NSAIDs can cause gastrointestinal symptoms, and the PPI helps prevent those symptoms.

    Naproxen works by reducing inflammation and pain in the body, while esomeprazole reduces the amount of acid produced in the stomach.

    Fact Table


    C14H14O3(Naproxen), C34H36MgN6O6S2(esomeprazole)


    US DailyMed


    95%(Naproxen), 90%(esomeprazole)

    Legal status


    Chemical Name


    Elimination half-life

    13-15 hr (Naproxen), 1.2-1.5 hr (esomeprazole)

    Dosage (Strength)

    375 / 20mg, 500 / 20mg


    Consult Doctor



    Protein binding

    99% (Naproxen), 97% (esomeprazole)

    PubChem CID

    156391 (Naproxen), 9568614 (esomeprazole)





    ATC code






    Routes of administration

    By mouth


    Take Vimovo by mouth twice daily with food. Use the lowest effective dose to treat pain levels.

    Vimovo is available in the following forms:

    • Naproxen-esomeprazole 375 mg/20 mg
    • Naproxen-esomeprazole 500 mg/20 mg


    The active ingredients in Vimovo are naproxen and esomeprazole.


    Common drug-drug interactions can include:

    • ACE inhibitors (e.g., lisinopril, enalapril)
    • Angiotensin II receptor blockers (ARBs) (e.g. losartan, valsartan)
    • Aspirin
    • Beta-blockers (e.g., metoprolol, carvedilol)
    • Chlorthalidone
    • Citalopram
    • Clopidogrel
    • Cyclosporine
    • Digoxin
    • Duloxetine
    • Eliquis
    • Escitalopram
    • Fluoxetine
    • Furosemide
    • Hydrochlorothiazide
    • Lithium
    • Lovenox
    • Methotrexate
    • Methotrexate
    • Methylprednisolone
    • Prednisone
    • Sertraline
    • Tacrolimus
    • Torsemide
    • Venlafaxine
    • Warfarin
    • Xarelto


    Tell your healthcare provider if you have a history of heart problems, high blood pressure, kidney problems, or asthma before using Vimovo.

    The medication can increase the risk of heart attack, stroke, and other serious side effects with long-term use.

    Long-term use of NSAIDs like naproxen can increase the risk of stomach bleeding and ulcers.

    Long-term use of PPIs like esomeprazole can increase the risk of bone fractures.

    Use caution if you have a history of liver or kidney problems.

    Do not take this medication if you are taking Plavix (clopidogrel).

    Side Effects

    Common side effects include:

    • Abdominal distension
    • Abdominal pain
    • Abnormal gait
    • Acute myocardial infarction
    • Bruise
    • Cerebrovascular accident
    • Constipation
    • Coronary thrombosis
    • Diarrhea
    • Dizziness
    • Dysgeusia
    • Flatulence
    • Gastritis
    • Gastroesophageal reflux disease
    • Gastrointestinal hemorrhage
    • Gastrointestinal inflammation
    • Gastrointestinal perforation
    • Gastrointestinal ulcer
    • Hematochezia
    • Peripheral edema
    • Upper abdominal pain
    • Urinary tract infection


    1. Vimovo [package insert]. Deerfield, IL: AstraZeneca; 2014.

    IMPORTANT NOTE: The above information is intended to increase awareness of health information and does not suggest treatment or diagnosis. This information is not a substitute for individual medical attention and should not be construed to indicate that use of the drug is safe, appropriate, or effective for you. See your health care professional for medical advice and treatment.

    Product Code : 12077

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