What is a Generic Drug?
A generic drug is a copy of the brand-name drug with the same dosage, safety, strength, quality, consumption method, performance, and intended use. Before generics become available on the market, the generic company must prove it has the same active ingredients as the brand-name drug and works in the same way and in the same amount of time in the body.
The only differences between generics and their brand-name counterparts is that generics are less expensive and may look slightly different (eg. different shape or color), as trademarks laws prevent a generic from looking exactly like the brand-name drug.
Generics are less expensive because generic manufacturers don't have to invest large sums of money to develop a drug. When the brand-name patent expires, generic companies can manufacture a copy of the brand-name and sell it at a substantial discount.
Vimovo (Naproxen/Esomeprazole Mag Trihydrate)
Prescription Required
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Product Details
Description
Your doctor may prescribe Vimovo to relieve the pain symptoms caused by osteoarthritis, rheumatoid arthritis, and ankylosing spondylitis.
Vimovo contains two active ingredients: naproxen, a nonsteroidal anti-inflammatory drug (NSAID), and esomeprazole, a proton pump inhibitor (PPI). Naproxen and other NSAIDs can cause gastrointestinal symptoms, and the PPI helps prevent those symptoms.
Naproxen works by reducing inflammation and pain in the body, while esomeprazole reduces the amount of acid produced in the stomach.
Fact Table
Formula
C14H14O3(Naproxen), C34H36MgN6O6S2(esomeprazole)
License
US DailyMed
Bioavailability
95%(Naproxen), 90%(esomeprazole)
Legal status
Rx-Only
Chemical Name
Naproxen/esomeprazole
Elimination half-life
13-15 hr (Naproxen), 1.2-1.5 hr (esomeprazole)
Dosage (Strength)
375 / 20mg, 500 / 20mg
Pregnancy
Consult Doctor
Brands
Vimovo
Protein binding
99% (Naproxen), 97% (esomeprazole)
PubChem CID
156391 (Naproxen), 9568614 (esomeprazole)
MedlinePlus
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ChEBI
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ATC code
M01AE52
DrugBank
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KEGG
D11576
Routes of administration
By mouth
Directions
Take Vimovo by mouth twice daily with food. Use the lowest effective dose to treat pain levels.
Vimovo is available in the following forms:
- Naproxen-esomeprazole 375 mg/20 mg
- Naproxen-esomeprazole 500 mg/20 mg
Ingredients
The active ingredients in Vimovo are naproxen and esomeprazole.
Interactions
Common drug-drug interactions can include:
- ACE inhibitors (e.g., lisinopril, enalapril)
- Angiotensin II receptor blockers (ARBs) (e.g. losartan, valsartan)
- Aspirin
- Beta-blockers (e.g., metoprolol, carvedilol)
- Chlorthalidone
- Citalopram
- Clopidogrel
- Cyclosporine
- Digoxin
- Duloxetine
- Eliquis
- Escitalopram
- Fluoxetine
- Furosemide
- Hydrochlorothiazide
- Lithium
- Lovenox
- Methotrexate
- Methotrexate
- Methylprednisolone
- Prednisone
- Sertraline
- Tacrolimus
- Torsemide
- Venlafaxine
- Warfarin
- Xarelto
Cautions
Tell your healthcare provider if you have a history of heart problems, high blood pressure, kidney problems, or asthma before using Vimovo.
The medication can increase the risk of heart attack, stroke, and other serious side effects with long-term use.
Long-term use of NSAIDs like naproxen can increase the risk of stomach bleeding and ulcers.
Long-term use of PPIs like esomeprazole can increase the risk of bone fractures.
Use caution if you have a history of liver or kidney problems.
Do not take this medication if you are taking Plavix (clopidogrel).
Side Effects
Common side effects include:
- Abdominal distension
- Abdominal pain
- Abnormal gait
- Acute myocardial infarction
- Bruise
- Cerebrovascular accident
- Constipation
- Coronary thrombosis
- Diarrhea
- Dizziness
- Dysgeusia
- Flatulence
- Gastritis
- Gastroesophageal reflux disease
- Gastrointestinal hemorrhage
- Gastrointestinal inflammation
- Gastrointestinal perforation
- Gastrointestinal ulcer
- Hematochezia
- Peripheral edema
- Upper abdominal pain
- Urinary tract infection
References
IMPORTANT NOTE: The above information is intended to increase awareness of health information and does not suggest treatment or diagnosis. This information is not a substitute for individual medical attention and should not be construed to indicate that use of the drug is safe, appropriate, or effective for you. See your health care professional for medical advice and treatment.Product Code : 12077
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