What is a Generic Drug?

A generic drug is a copy of the brand-name drug with the same dosage, safety, strength, quality, consumption method, performance, and intended use. Before generics become available on the market, the generic company must prove it has the same active ingredients as the brand-name drug and works in the same way and in the same amount of time in the body.

The only differences between generics and their brand-name counterparts is that generics are less expensive and may look slightly different (eg. different shape or color), as trademarks laws prevent a generic from looking exactly like the brand-name drug.

Generics are less expensive because generic manufacturers don't have to invest large sums of money to develop a drug. When the brand-name patent expires, generic companies can manufacture a copy of the brand-name and sell it at a substantial discount.

Vraylar (Cariprazine)

Also Known as Reagila

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Brand

Vraylar (Cariprazine)

Prescription Required

Strength
Qty
1.5mg
3mg
4.5mg
6mg

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  • Product Details

    Description

    Vraylar is a prescription drug used to treat schizophrenia and bipolar disorder

    Vraylar is effective at treating thought and mood disorders. It works by modulating the effects of dopamine in the brain. 

    Fact Table

    Formula

    C21H32Cl2N4O

    License

    US FDA

    Bioavailability

    High

    Legal status

    Rx-only

    Chemical Name

    Cariprazine

    Elimination half-life

    2–5 days

    Dosage (Strength)

    1.5mg, 3mg, 4.5mg, 6mg

    Pregnancy

    Consult Doctor

    Brands

    Vraylar, Reagila

    Protein binding

    91–97%

    PubChem CID

    11154555

    MedlinePlus

    a615050

    ChEBI

    90933

    ATC code

    N05AX15

    DrugBank

    DB06016

    KEGG

    D09997

    Routes of administration

    By mouth

    Directions

    The usual starting dose of Vraylar is 1.5 mg once daily.

    Your doctor may increase your dose to 1.5-6 mg once daily, depending on the condition being treated.

    Take Vraylar exactly as prescribed by your doctor. 

    Ingredients

    The active ingredient in Vraylar is cariprazine. 

    Interactions

    Vraylar has many potential drug-drug interactions, including: 

    • Amiodarone
    • Apalutamide
    • Aprepitant
    • Atazanavir
    • Berotralstat
    • Bexarotene
    • Bosentan
    • Carbamazepine
    • Cenobamate
    • Ceritinib
    • Cimetidine
    • Clarithromycin
    • Conivaptan
    • Crizotinib
    • Cyclosporine
    • Dabrafenib
    • Darunavir
    • Dexamethasone
    • Diltiazem
    • Dipyrone
    • Dronedarone
    • Duvelisib
    • Efavirenz
    • Enzalutamide
    • Erythromycin
    • Eslicarbazepine
    • Etravirine
    • Fedratinib
    • Fluconazole
    • Fosamprenavir
    • Fosaprepitant
    • Fosphenytoin
    • Grapefruit juice
    • Idelalisib
    • Imatinib
    • Indinavir
    • Itraconazole
    • Ketoconazole
    • Lefamulin
    • Letermovir
    • Lonafarnib
    • Lopinavir
    • Lorlatinib
    • Lumacaftor
    • Lumacaftor-ivacaftor
    • Mifepristone
    • Mitotane
    • Modafinil
    • Nafcillin
    • Nefazodone
    • Nelfinavir
    • Netupitant
    • Nilotinib
    • Pexidartinib
    • Phenobarbital
    • Phenytoin
    • Posaconazole
    • Primidone
    • Ribociclib
    • Rifabutin
    • Rifampin (rifampicin)
    • Rifapentine
    • Saquinavir
    • Schisandra
    • St. John's wort
    • Telithromycin
    • Tucatinib
    • Verapamil
    • Voriconazole

    Cautions

    Vraylar and other antipsychotic medications should not be used to treat dementia-related psychosis in older adults.

    Tell your doctor if you experience suicidal thoughts or behaviors while taking Vraylar.

    Tell your doctor if you have a history of kidney or liver problems. 

    Use with caution if you have a history of seizure disorders.

    Side Effects

    The most common side effects with Vraylar may include:

    • Abdominal pain
    • Akathisia
    • Anxiety
    • Arthralgia
    • Suicidal ideation
    • Back pain
    • Blurred vision
    • Constipation
    • Decreased appetite
    • Diarrhea
    • Dizziness
    • Drowsiness
    • Dyspepsia
    • Dystonia
    • Extrapyramidal reactions
    • Fatigue
    • Headache
    • Hypertension
    • Increased creatinine phosphokinase
    • Increased liver enzymes
    • Insomnia
    • Agitation
    • Limb pain
    • Muscle rigidity
    • Nausea
    • Parkinsonian-like syndrome
    • Restlessness
    • tachycardia
    • Toothache
    • Vomiting
    • Weight gain
    • Xerostomia

    References

    Vraylar [package insert]. Parsippany, NJ: Actavis; 2015.


    IMPORTANT NOTE: The above information is intended to increase awareness of health information and does not suggest treatment or diagnosis. This information is not a substitute for individual medical attention and should not be construed to indicate that use of the drug is safe, appropriate, or effective for you. See your health care professional for medical advice and treatment.

    Product Code : 13344

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