Description
Vraylar is a prescription drug used to treat schizophrenia and bipolar disorder.
Vraylar is effective at treating thought and mood disorders. It works by modulating the effects of dopamine in the brain.
Fact Table |
Formula |
C21H32Cl2N4O |
License |
US FDA |
Bioavailability |
High |
Legal status |
Rx-only |
Chemical Name |
Cariprazine |
Elimination half-life |
2–5 days |
Dosage (Strength) |
1.5mg, 3mg, 4.5mg, 6mg |
Pregnancy |
Consult Doctor |
Brands |
Vraylar, Reagila |
Protein binding |
91–97% |
PubChem CID |
11154555 |
MedlinePlus |
a615050 |
ChEBI |
90933 |
ATC code |
N05AX15 |
DrugBank |
DB06016 |
KEGG |
D09997 |
Routes of administration |
By mouth |
Directions
The usual starting dose of Vraylar is 1.5 mg once daily.
Your doctor may increase your dose to 1.5-6 mg once daily, depending on the condition being treated.
Take Vraylar exactly as prescribed by your doctor.
Ingredients
The active ingredient in Vraylar is cariprazine.
Interactions
Vraylar has many potential drug-drug interactions, including:
- Amiodarone
- Apalutamide
- Aprepitant
- Atazanavir
- Berotralstat
- Bexarotene
- Bosentan
- Carbamazepine
- Cenobamate
- Ceritinib
- Cimetidine
- Clarithromycin
- Conivaptan
- Crizotinib
- Cyclosporine
- Dabrafenib
- Darunavir
- Dexamethasone
- Diltiazem
- Dipyrone
- Dronedarone
- Duvelisib
- Efavirenz
- Enzalutamide
- Erythromycin
- Eslicarbazepine
- Etravirine
- Fedratinib
- Fluconazole
- Fosamprenavir
- Fosaprepitant
- Fosphenytoin
- Grapefruit juice
- Idelalisib
- Imatinib
- Indinavir
- Itraconazole
- Ketoconazole
- Lefamulin
- Letermovir
- Lonafarnib
- Lopinavir
- Lorlatinib
- Lumacaftor
- Lumacaftor-ivacaftor
- Mifepristone
- Mitotane
- Modafinil
- Nafcillin
- Nefazodone
- Nelfinavir
- Netupitant
- Nilotinib
- Pexidartinib
- Phenobarbital
- Phenytoin
- Posaconazole
- Primidone
- Ribociclib
- Rifabutin
- Rifampin (rifampicin)
- Rifapentine
- Saquinavir
- Schisandra
- St. John's wort
- Telithromycin
- Tucatinib
- Verapamil
- Voriconazole
Cautions
Vraylar and other antipsychotic medications should not be used to treat dementia-related psychosis in older adults.
Tell your doctor if you experience suicidal thoughts or behaviors while taking Vraylar.
Tell your doctor if you have a history of kidney or liver problems.
Use with caution if you have a history of seizure disorders.
Side Effects
The most common side effects with Vraylar may include:
- Abdominal pain
- Akathisia
- Anxiety
- Arthralgia
- Suicidal ideation
- Back pain
- Blurred vision
- Constipation
- Decreased appetite
- Diarrhea
- Dizziness
- Drowsiness
- Dyspepsia
- Dystonia
- Extrapyramidal reactions
- Fatigue
- Headache
- Hypertension
- Increased creatinine phosphokinase
- Increased liver enzymes
- Insomnia
- Agitation
- Limb pain
- Muscle rigidity
- Nausea
- Parkinsonian-like syndrome
- Restlessness
- tachycardia
- Toothache
- Vomiting
- Weight gain
- Xerostomia
References
Vraylar [package insert]. Parsippany, NJ: Actavis; 2015.
About Dr. Conor Sheehy (Page Author)
Dr. Sheehy (BSc Molecular Biology, PharmD) works a clinical pharmacist specializing in cardiology, oncology, and ambulatory care. He’s a board-certified pharmacotherapy specialist (BCPS), and his experience working one-on-one with patients to fine tune their medication and therapy plans for optimal results makes him a valuable subject matter expert for our pharmacy. Read More....
IMPORTANT NOTE:
The above information is intended to increase awareness of health information and does not suggest treatment or diagnosis. This information is not a substitute for individual medical attention and should not be construed to indicate that use of the drug is safe, appropriate, or effective for you. See your health care professional for medical advice and treatment.
Product Code : 13344