What is a Generic Drug?
A generic drug is a copy of the brand-name drug with the same dosage, safety, strength, quality, consumption method, performance, and intended use. Before generics become available on the market, the generic company must prove it has the same active ingredients as the brand-name drug and works in the same way and in the same amount of time in the body.
The only differences between generics and their brand-name counterparts is that generics are less expensive and may look slightly different (eg. different shape or color), as trademarks laws prevent a generic from looking exactly like the brand-name drug.
Generics are less expensive because generic manufacturers don't have to invest large sums of money to develop a drug. When the brand-name patent expires, generic companies can manufacture a copy of the brand-name and sell it at a substantial discount.
Vyzulta (Latanoprostene Bunod)
Prescription Required
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Product Details
Description
VYZULTA (Latanoprostene bunod) is an ophthalmic (eye drop) medication used to reduce pressure in the fluid of the eyes (intraocular pressure) in patients with either ocular hypertension or open-angle glaucoma.
When VYZULTA eye drops are applied, the active ingredient is split into two active moieties: latanoprost and butanediol mononitrate.
Latanoprost increases the amount of aqueous humor (fluid in the eye) that exits the eye, contributing to the lowering of ocular pressure. Butanediol mononitrate releases nitric oxide, which relaxes the trabecular meshwork.
Fact Table
Formula
C27H41NO8
License
US DailyMed
Bioavailability
-
Legal status
Rx-Only
Chemical Name
Latanoprostene bunod
Elimination half-life
1.8–4.6 hours
Dosage (Strength)
0.024%/5ml
Pregnancy
Not Recommended
Brands
Vyzulta
Protein binding
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PubChem CID
11156438
MedlinePlus
a618001
ChEBI
177703
ATC code
S01EE06
DrugBank
DB11660
KEGG
D10441
Routes of admsinistration
Eye drop
Directions
Apply one drop to the affected eye (s) once daily.
If you are using VYZULTA with other eye drops, separate them by at least 5 minutes.
Ingredients
The active ingredient in VYZULTA is latanoprostene bunod.
Inactive ingredients include benzalkonium chloride, citric acid, EDTA, glycerin, polysorbate 80, sodium citrate, and water.
Cautions
Prostaglandin analogs like VYZULTA may cause changes in the color of the iris and eyelid. VYZULTA increases the amount of melanin in the affected tissue, causing a darkening of the eye. The changes are often permanent, and most likely to affect those with lighter colored eyes. Color change may take months or years to become apparent.
VYZULTA may change the length and thickness of eyelashes. Eyelashed return to normal after stopping VYZULTA.
Do not touch the tip of the applicator to the surface of the eye or other non-sterile surfaces. Doing so may contaminate the product and lead to an infection of the eye.
Remove contact lens 15 minutes before applying VYZULTA.
Side Effects
The most common adverse effects of VYZULTA include:
- Conjunctival edema
- Conjunctival hyperemia
- Conjunctival irritation
- Eye irritation
- Eye pain
- Foreign body sensation
- Instillation site pain
- Ocular hyperemia
- Punctate keratitis
References
- Vyzulta. [package insert] Bridgewater, NJ: Valeant Pharmaceuticals; 2017.
IMPORTANT NOTE: The above information is intended to increase awareness of health information and does not suggest treatment or diagnosis. This information is not a substitute for individual medical attention and should not be construed to indicate that use of the drug is safe, appropriate, or effective for you. See your health care professional for medical advice and treatment.Product Code : 13213
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